Roman-Ulrich Müller

Improving precision diagnosis in unexplained CKD Comment on Halbritter et al. „Chronic Kidney Disease of unexplained cause (CKDx): a consensus statement by the Genes & Kidney Working Group of the ERA

The important pediatric perspective on CKDx. Moving nephrology towards precision medicine is an effort spanning all age groups.

Improving precision diagnosis in unexplained CKD url: academic.oup.com/ckj/article/...

journals.lww.com/kidney360/fu...

YouTube video by MARKUS at HOMe SGLT-2 I in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller

SGLT-2 Inhibition in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller

youtu.be/9e-UFBnIyDI?...

@ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social

Transition of patients with hereditary nephropathies from pediatric to adult care Abstract. Adolescents and young adults with chronic kidney disease (CKD), particularly those with genetic kidney diseases, face unique challenges as they t

Transition of patients with hereditary nephropathies from pediatric to adult care url: academic.oup.com/ndt/article-...

Transition…such an important topic for improving patient care…but still underrepresented in care pathways.

YouTube video by MARKUS at HOMe ADPKD: KDIGO GL / ERA Genes & Kidney WG - Prof. Roser Torra, Prof. Roman-Ulrich Müller

Tonight it's all about ADPKD!

KDIGO Guidelines / ERA Genes & Kidney Working Group - Prof. Roser Torra, Prof. Roman-Ulrich Müller

youtu.be/qjnYDsYbx0Q?...

@rosertorra.bsky.social @muellerrom.bsky.social @dguerrot.bsky.social @gunnarheine.bsky.social @kronbichlerlab.bsky.social

📹 Interested in a PhD position in aging research starting in 2026? Then watch our new short video for some tips from our wonderful PhD students and faculty.
Don't miss the deadline: November 3, 2025.
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KDIGO 2025 ADPKD Guideline: A commentary on diagnosis and management of hepatopancreatic manifestations by the ERA Working Group Genes & Kidney by Drs. @muellerrom.bsky.social , @joostphdrenth.bsky.social, et al.

academic.oup.com/ndt/article/...

KDIGO 2025 ADPKD Guideline: A commentary on diagnosis and management of hepatopancreatic manifestations by the ERA Working Group Genes & Kidney Abstract. The Kidney Disease: Improving Global Outcomes (KDIGO) 2025 Clinical Practice Guideline for the Evaluation, Management, and Treatment of Autosomal

The KDIGO ADPKD Guideline is a milestone for the field.

Building upon this work, experts assembled by the ERA Working Group Genes&Kidney now provide additional practical guidance for polycystic liver disease in #ADPKD.

academic.oup.com/ndt/article/...

@ecorneclegall.bsky.social

CKDx: Simplicity matters, implementation is key Emilie Cornec-Le Gall, Jan Halbritter, Roman Ulrich Müller; CKDx: Simplicity matters, implementation is key, Nephrology Dialysis Transplantation, , gfaf137

CKDx: Simplicity matters, implementation is key url: academic.oup.com/ndt/article/...

At this stage, it is all about widespread adoption of a simple concept: we do not always know the diagnosis in kidney disease. And reporting diagnostic steps in a simple manner enables us to go the next step.

Apply now for a fully funded #PhD position at the Cologne Graduate School of Ageing Research and become part of our vibrant #AgingResearch commmuny.
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📣 Spread the news!

10 tips on how to take a proper family history in CKD patient care Abstract. Patients with chronic kidney disease (CKD) often present with a family burden of disease. However, efficient collection and documentation of fami

Obtaining a thorough family history is so important in kidney disease....but often more difficult than expected in clinical practice...

10 tips on how to take a proper family history in CKD patient care url: academic.oup.com/ckj/article/...

YouTube video by UniversitaetzuKoeln Nierenerkrankungen anhand von Bluttest vorhersagen // Wissenschaftsnachrichtenvideo

Happy to share the nice video @unicologne.bsky.social has produced on our recent publication identifying novel protein biomarkers for #ADPKD.
www.youtube.com/watch?v=FDGN...
rdcu.be/ezvN4
@cecad.bsky.social @uniklinikkoeln.bsky.social

Absolutely. But still no funding to implement these spectacular findings…😉 I guess this will be a long learning process for policymakers…

Beyond classic stress signalling: how mitochondrial stress softens the cell nucleus and alters cellular identity A University of Cologne research team has discovered that cells in high-energy-demanding tissues respond to mitochondrial dysfunction in a surprising way. Instead of shutting down, cells adjust their ...

What happens when #mitochondria fail in high-energy tissues? Cells adjust their metabolism and alter the mechanics of the nucleus! Read more on the discovery by Dr. Harshita Kaul from the Trifunovic Lab in Nature Metabolism.

➡️ uni.koeln/QZURH

#CellStress #NatureMetabolism @unicologne.bsky.social

Bluttest sagt voraus, wie schnell Nieren ihre Funktion einstellen Ein Forschungsteam der Universität zu Köln hat einen neuartigen Ansatz entwickelt, um anhand von Blutproben vorherzusagen, wie schnell eine Nierenerkrankung fortschreiten wird.

Mithilfe von #Massenspektrometrie ist es einem Team um @muellerrom.bsky.social ‪vom @cecad.bsky.social an der @unicologne.bsky.social ‪und der @uniklinikkoeln.bsky.social ‪ gelungen, den Verlauf von Erkrankungen der #Nieren anhand einer Blutprobe deutlich genauer vorherzusagen als bisher möglich.

KDIGO ADPKD Guideline: A Milestone in Genetic Kidney Diseases Why is a global guideline for ADPKD so important?

Prof. Roman Müller explains how the new KDIGO guideline marks a crucial step forward in harmonizing care for patients with #ADPKD) worldwide 👇

Great thanks to Jörg Bernards-Stiftung and @dfg.de (Excellence Strategy @cecad.bsky.social) for supporting this work and to all patients participating.

MSCA PF 2025 UzK Hosting Offer - The impact of kidney disease on well-being - a translational approach (Roman Müller Lab)

Interested in a postdoctoral fellowship on polycystic kidney disease? Linking molecular data with outcome? Please get in touch.

euraxess.ec.europa.eu/jobs/hosting...

Untargeted. Targeted assays for absolute quantification in a prospective study will now have to be the next step towards implementation

📎 Read the full study here: Nature Commun. 16, 6646 (2025) – DOI 10.1038/s41467-025-61887-8

10/ This work was enabled by all patients participating and central support by the Jörg Bernards-Stiftung and @DFG through the Excellence Initiative (@CECAD). Thank you!
@cecad.bsky.social @unicologne.bsky.social @uniklinikkoeln.bsky.social and Center for Molecular Medicine Cologne

9/ Next steps:
• Develop targeted assays for the 6 proteins
• Prospective multicenter validation
• Explore integration with other data layers (e.g. metabolomics) and treatment response
• Ultimate goal: precision-medicine profiling for ADPKD care rdcu.be/exbNq

8/ Why it matters:
✅ Blood-based protein markers are inexpensive and accessible
✅ They improve prediction where MRI and genetics may fall short
✅ Pave the way for targeted assays (e.g. ELISA, mass spec) and prospective clinical use rdcu.be/exbNq

7/ Notably, the proteome data adds predictive information independent of eGFR at baseline. In ROC analysis for identifying rapid progressors (>3 ml/min/yr) adding the protein to MIC enhanced the AUC rdcu.be/exbNq

6/ These models were cross-validated in two large cohorts: an internal cohort (Cologne) and an external cohort using EDTA plasma instead of serum (Groningen). rdcu.be/exbNq

5/ The model based on these 6 proteins was superior to a clinical standard model based on eGFR and Mayo Imaging Class (MIC). Adding the proteins to the clinical standard further improved the model. rdcu.be/exbNq

4/ Using weighted LASSO, we narrowed it to 6 key proteins:
• GPX3 (oxidative stress)
• SERPINF1 (angiogenesis regulator)
• AFM (vitamin E transport)
• FERMT3 (cell adhesion)
• CFHR1 (complement pathway)
• RARRES2 (inflammation/adipogenesis) rdcu.be/exbNq

3/ We analyzed serum from large cohorts via semi-automated mass spectrometry. Identified 29 proteins significantly linked to yearly eGFR decline rdcu.be/exbNq

2/ ADPKD is the most common genetic cause of kidney failure. Predicting how fast kidney function (eGFR) declines is crucial for tailored therapy (e.g. whether to prescribe tolvaptan) and for patient counseling rdcu.be/exbNq

Developing serum proteomics based prediction models of disease progression in ADPKD Nature Communications - Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst formation and loss of kidney function, yet prognostic biomarkers remain limited....

1/ 🧬 Exciting news! Our group just published a paper in Nature Communications on using serum proteomics to predict disease progression in #ADPKD (Autosomal Dominant Polycystic Kidney Disease) 🔬 — enhancing risk stratification beyond currently available models 🎯 rdcu.be/exbNq