Marija Krasiļņikova

Our lab has two funded PhDs to start in 2026 via the NorthWestBio programme

Project details here
www.gla.ac.uk/postgraduate...
...and here
www.gla.ac.uk/postgraduate...

Application deadline is Nov 21st 2025; apply here:
www.gla.ac.uk/postgraduate...

Targets of the human antibody response to the variant surface glycoprotein of Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/41040341/

The UTRs of Leishmania donovani vary in length and are enriched in potential regulatory structures pubmed.ncbi.nlm.nih.gov/41040140/

Phylogenomics of free-living neobodonids reveals they are a paraphyletic group from which all other metakinetoplastids are descended www.biorxiv.org/content/10.1101/2025.10.03.680260v1

Splice site diversity and abundance of non-canonical introns in diplonemids (Diplonemea, Euglenozoa) pubmed.ncbi.nlm.nih.gov/41027712/

First Genome-Wide Centromere Map of Trypanosoma cruzi Reveals Linear and 3D Compartment Boundaries and Spatial Clustering www.biorxiv.org/content/10.1101/2025.09.26.678825v1

Trypanosome histone variants H3.V and H4.V promote nucleosome plasticity in repressed chromatin. www.biorxiv.org/content/10.1101/2025.09.24.678203v1

The mitotic spindle kinase MSK co-ordinates segregation of the nucleus and kinetoplast in Leishmania mexicana www.biorxiv.org/content/10.1101/2025.09.19.677349v1

New pre-print from Guy @goldrieve.bsky.social on vsgseq2 - a much improved, robust tool to analyse VSG expression in tryps

vsgseq2: an updated pipeline for analysis of the diversity and abundance of population-wide Trypanosoma brucei VSG expression www.biorxiv.org/content/10.1101/2025.09.12.675796v1

Chemical genetics reveals Leishmania KKT2 and CRK9 kinase activity is required for cell cycle progression www.biorxiv.org/content/10.1101/2025.09.08.674917v1

Save the dates!! @bspparasitology.bsky.social Spring Meeting 2026 will be in Bonnie Glasgow! 7-9 April 2026, with a drinks reception in Glasgow City Chambers on the 6th of April 2026!
Keep an eye on the BSP website for registration and abstract submission!
Logo by @shannaraeilean.bsky.social! 🦟

A novel high-throughput single-cell DNA sequencing method reveals hidden genomic heterogeneity in the unicellular eukaryote Leishmania www.biorxiv.org/content/10.1101/2025.09.10.675331v1

Transcriptomic and proteomic analysis of quiescent epimastigotes as a resource for investigating Trypanosoma cruzi persistence. www.biorxiv.org/content/10.1101/2025.09.09.675056v1

Genome-wide overexpression screen reveals a novel transcription termination factor in Trypanosoma brucei www.biorxiv.org/content/10.1101/2025.09.02.673782v1

A Trypanosome Trifecta: an independently tunable triple inducer system for genetic studies in Trypanosoma brucei. www.biorxiv.org/content/10.1101/2025.08.31.673413v1

How do parasites strategically organise their genomes to influence gene expression? If you’re curious, check our latest review in @cp-trendsparasitol.bsky.social !

@biologyatyork.bsky.social @ybri-uoy.bsky.social @pasteur.fr

www.sciencedirect.com/science/arti...

Single-molecule landscape of DNA replication pausing https://www.biorxiv.org/content/10.1101/2025.08.14.670160v1

The absence of the Leishmania major telomerase TERT component links telomeres and cell homeostasis with infectivity pubmed.ncbi.nlm.nih.gov/40848782/

Leishmania major chromosomes are replicated from a single high-efficiency locus supplemented by thousands of lower efficiency initiation events DNA replication initiates at genome sites termed origins. Previous origin mapping approaches in the populations of the protozoan parasite Leishmania m…

We’re pleased to share our new study, led by @jezieldamasceno.bsky.social, that used long-read, single molecule sequencing to reveal the full (?) picture of Leishmania DNA replication. Thanks, Mike Boemo and helpful reviewers @uofgsii.bsky.social

www.sciencedirect.com/science/arti...

Integrating tRNA gene epigenomics and expression with codon usage unravels an intricate connection with translatome dynamics in Trypanosoma cruzi pubmed.ncbi.nlm.nih.gov/40788054/

Trypanosoma cruzi surface components: Why so many? Why so polymorphic? pubmed.ncbi.nlm.nih.gov/40774760/

Leishmania major chromosomes are replicated from a single high-efficiency locus supplemented by thousands of lower efficiency initiation events pubmed.ncbi.nlm.nih.gov/40768333/

Discovery of unique mitotic mechanisms in <em>Paradiplonema papillatum</em> pubmed.ncbi.nlm.nih.gov/40763799/

Pleased 2 share our new article: single-molecule replication mapping in Leishmania using DNAscent.
We show widespread stochastic origin firing and insights into genome variability.

www.cell.com/cell-reports...

Decoding post-transcriptional gene expression controls in trypanosomatids using machine learning pubmed.ncbi.nlm.nih.gov/40735494/

Using the DNA language model, GROVER, to parse sequence and epigenetic effects on genome stability https://www.biorxiv.org/content/10.1101/2025.07.23.666402v1

The microtubule-severing enzyme spastin regulates spindle dynamics to promote chromosome segregation in Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/40702310/

G4s mapped in T. brucei using ChIPseq - finally!

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions https://www.biorxiv.org/content/10.1101/2025.07.22.666098v1