Eloi Littner's Avatar

Eloi Littner

@eloilittner.bsky.social

PhD in Biology (Génétique et Génomique) Evolution of integrons, in the lab of @epcrocha.bsky.social, Microbial evolutionary genomics @pasteur.fr @EPFL and @Polytechnique alumni

147 Followers  |  212 Following  |  8 Posts  |  Joined: 27.02.2025  |  2.0939

Latest posts by eloilittner.bsky.social on Bluesky

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Bacterial natural transformation drives cassette shuffling and simplifies recombination in chromosomal integrons Abstract. Integrons act as biobanks of gene cassettes conferring functions crucial for bacterial defense, including protection against phages and antibioti

Our new paper is out in @narjournal.bsky.social We show that natural transformation enables bacteria to shuffle integron cassettes, boosting their phenotypic diversity.
academic.oup.com/nar/article/... 1/5

17.11.2025 15:44 — 👍 47    🔁 23    💬 3    📌 1

Happy to be part of this! Besides conjugation, another way to acquire integron cassettes 🧬📼

18.11.2025 07:04 — 👍 7    🔁 0    💬 0    📌 0
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Prix Universitaires - Chancellerie des Universités de Paris - Sorbonne Les Prix Universitaires de la Chancellerie des Universités de Paris - Sorbonne : prix solennels, prix de thèse en droit et en sciences économiques.

🎓🏆 Two Institut Pasteur PhD students honored at the 2025 Chancellerie des Universités de Paris Prizes!

👏 @nellsaunders.bsky.social – coronavirus research

👏 Antonin Verdier – optogenetic implant for hearing restoration

Excellence in doctoral research 🌟

www.sorbonne.fr/la-chancelle...

31.10.2025 09:47 — 👍 11    🔁 3    💬 0    📌 0
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Use antisense oligomers to silence phage genes and discover new biology.
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social @helmholtzhzi.bsky.social @uni-wuerzburg.de
print: www.nature.com/articles/s41...
highlight: www.nature.com/articles/s41...
briefing: www.nature.com/articles/d41...

31.10.2025 08:07 — 👍 22    🔁 10    💬 0    📌 0
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Une piste prometteuse pour augmenter l’efficacité des antibiotiques Les aminosides sont des antibiotiques efficaces contre de très nombreuses bactéries telles que Escherichia coli, Pseudomonas aeruginosa ou Staphylococcus aureus. Mais jusqu’à présent, personne ne sava...

🦠💊 L’Institut @pasteur.fr vient de publier un communiqué de presse sur nos récents travaux, qui décrivent une nouvelle piste pour augmenter l’efficacité des antibiotiques. #Pasteurdon #Recherche #Science #AMR

Merci à toutes celles et ceux qui ont contribué.

📘 English version coming soon!

31.10.2025 10:37 — 👍 28    🔁 16    💬 0    📌 1

Thanks Ben! Still have to figure it out 😉

20.10.2025 16:37 — 👍 0    🔁 0    💬 0    📌 0
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The multifaceted roles of NAD+ in bacterial immunity In this review, Vaysset and Bernheim examine how nicotinamide adenine dinucleotide (NAD+) is a key player in diverse and widespread bacterial antiphage defense systems and phage counterdefense. The au...

Many antiphage systems use NAD+, in many ways.
@hugovaysset.bsky.social reviewed them all!

Read to know more about all their molecular mechanisms, how phages counteract them, their distribution in bacteria and their conservation in eukaryotic immunity!
www.cell.com/molecular-ce...

17.10.2025 17:55 — 👍 67    🔁 24    💬 1    📌 2
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On Thursday, October 9th, I successfully defended my PhD in Genetics and Genomics, on the diversity, function and evolution of integron cassettes, at @pasteur.fr. Thanks to my PhD supervisor, @epcrocha.bsky.social and to my jury, headed by Ingrid Lafontaine!

18.10.2025 17:25 — 👍 19    🔁 1    💬 4    📌 0
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Evolution of gut microbiota across honeybee species revealed by comparative metagenomics Nature Communications - Here, the authors perform metagenomic analysis of honeybee gut microbes, uncovering many previously unidentified species and host specific differences in composition and...

Happy to announce that our comparative metagenomic analysis of the gut microbiota of five honeybee species - spearheaded by @aiswarya.bsky.social - is finally published in a peer-reviewed journal! rdcu.be/eKMCs @fbm-unil.bsky.social @dmf-unil.bsky.social 🧵👇

14.10.2025 19:04 — 👍 62    🔁 22    💬 1    📌 2
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Resistance mutation supply modulates the benefit of CRISPR immunity against virulent phages Only a fraction of bacterial genomes encode CRISPR-Cas systems but the selective causes of this variation are unexplained. How naturally virulent bacteriophages (phages) select for CRISPR immunity has...

New preprint!

Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠

Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare!

An epic effort by Rosanna Wright

www.biorxiv.org/content/10.1...

06.10.2025 06:27 — 👍 108    🔁 52    💬 3    📌 1
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Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n

25.09.2025 21:28 — 👍 298    🔁 153    💬 14    📌 8
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Génétique : l’ADN des bactéries comme source de savoirs Un pan de la recherche en génomique se propose d'étudier les bactéries, ces micro-organismes développent des mécanismes de défense particulièrement intéressants.

[Podcast] Les chantiers de la recherche | "Génétique : l'ADN des bactéries comme source de savoirs" avec @eloilittner.bsky.social

15.09.2025 09:08 — 👍 4    🔁 2    💬 0    📌 0
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Génétique : l’ADN des bactéries comme source de savoirs Un pan de la recherche en génomique se propose d'étudier les bactéries, ces micro-organismes développent des mécanismes de défense particulièrement intéressants.

Et bien c'est fait ! Première à l'antenne d'une radio nationale, dans la matinale de France Culture ce matin. Merci à Guillaume Erner de m'avoir accueilli, et à Juliette Devaux pour la préparation de l'émission.

www.radiofrance.fr/francecultur...

15.09.2025 07:45 — 👍 4    🔁 2    💬 0    📌 0

Willing to join us @pasteur.fr for a PhD for a project on how interactions between mobile genetic elements shape bacterial adaptation? Subject to be tailored to candidates with keen interest in evolution, genomics, computational biology, microbiology. Check www.pasteur.fr/en/education...

08.09.2025 08:56 — 👍 45    🔁 58    💬 0    📌 0
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Les Chantiers de la recherche : écouter le podcast et replay | France Culture Chaque matin, entrez dans les coulisses de la recherche, avec celles et ceux qui la font vivre. Dans un laboratoire, une bibliothèque ou sur un terrain de fouilles, des chercheuses et des chercheurs n...

J'aurai la chance de présenter mes travaux de thèse sur France Culture, dans l'émission "Les Chantiers de la Recherche" ce lundi 15 à 6h45, avec Guillaume Erner. Pour les lève-tard, l'émission sera disponible en podcast. Stay tuned !

www.radiofrance.fr/francecultur...

13.09.2025 17:04 — 👍 8    🔁 1    💬 0    📌 0

Check out @julielebris.bsky.social’s thread on our latest manuscript describing phenotypic heterogeneity in capsule production in Klebsiella & Acinetobacter @klebclub.bsky.social

This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social
#microsky #phagesky

09.09.2025 05:11 — 👍 18    🔁 11    💬 0    📌 0
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A new theme issue of #PhilTransB examines the evolutionary history of bacterial immune systems, their modes of action, and the patterns how different bacterial immune systems are distributed across different ecosystems. Read: buff.ly/Z4qdxY1

05.09.2025 16:01 — 👍 38    🔁 27    💬 1    📌 1

At last ! A tool specifically for phage-plasmid hunters. Check tyPPing by @karinailchenko.bsky.social and @eugenpfeifer.bsky.social

03.09.2025 14:00 — 👍 47    🔁 16    💬 0    📌 0
ERC Starting Grants were awarded to (clockwise): Jerome Beetz, Mona Garvert, Beatrice Baragli, Jake Greenfield, Jens Hör, and Jacqueline Degen. (Photos: Robert Emmerich / Kerstin Flake / Daniel Hanoch / Chris Weiss / Nik Schölzel / Thomas Hovestadt)

ERC Starting Grants were awarded to (clockwise): Jerome Beetz, Mona Garvert, Beatrice Baragli, Jake Greenfield, Jens Hör, and Jacqueline Degen. (Photos: Robert Emmerich / Kerstin Flake / Daniel Hanoch / Chris Weiss / Nik Schölzel / Thomas Hovestadt)

We are very proud of our researchers Beatrice Baragli, Jerome Beetz, Jacqueline Degen, Mona Garvert, Jake Greenfield, and Jens Hör: They have been awarded prestigious ERC Starting Grants worth €1.5 million. Congratulations! @erc.europa.eu #ERCStG
➡️ www.uni-wuerzburg.de/en/news-and-...

04.09.2025 10:10 — 👍 33    🔁 7    💬 0    📌 3
Photo: HIRI / Nik Schölzel

Photo: HIRI / Nik Schölzel

Congratulations to our #HIRI group leader and JMU junior professor @jenshoer.bsky.social on receiving a 1.5 million euro #ERCStG from @erc.europa.eu! In his RIBO-PHAGE project, he will study phages—viruses that infect bacteria—with RNA genomes. 🥳👏 @helmholtzhzi.bsky.social @uni-wuerzburg.de

04.09.2025 10:32 — 👍 38    🔁 3    💬 2    📌 0
1.5 million euros for research into “bacterial killers” ERC Starting Grant awarded to Jens Hör from the Helmholtz Institute Würzburg

I'm really happy to have been granted an @erc.europa.eu Starting Grant! We'll study the molecular principles of RNA phages—from infection to replication to bacterial immunity. Interested in joining? Feel free to reach out! Formal job ads to follow.

More info here:

tinyurl.com/RIBO-PHAGE

#ERCStG

04.09.2025 10:42 — 👍 71    🔁 6    💬 8    📌 1

Preprint: We discovered phage proteins that sequester diverse immune signaling molecules, including cUMP, cCMP, and N7-cADPR

The first viral sponges to inhibit Pycsar and type IV Thoeris

Congrats to talented leading author Romi Hadary! Read her thread to learn more about our findings

25.08.2025 13:00 — 👍 48    🔁 15    💬 0    📌 1

Mind-blowing tour-de-force for synthetic biology and immunity 🤯
Congrats @garbjeremy.bsky.social and @soreklab.bsky.social 🤩

02.09.2025 12:57 — 👍 4    🔁 1    💬 0    📌 0
Portrait Jens Hör

Portrait Jens Hör

Im Kampf gegen multiresistente Keime können #Bakteriophagen eine weitere Waffe sein. Für sein Projekt "RIBO-PHAGE" erhält @jenshoer.bsky.social, Nachwuchsgruppenleiter @helmholtz-hiri.bsky.social, nun einen #ERCStG des @erc.europa.eu!🎉 Herzlichen Glückwunsch!
www.helmholtz-hzi.de/media-center...

04.09.2025 10:02 — 👍 28    🔁 6    💬 2    📌 0

Super excited to receive the ERC starting grant to explore what phage-bacteria interactions can teach us on host-pathogen conflicts 🤩 I'm immensely grateful to my wonderful team and to present and past mentors 🙏

04.09.2025 11:40 — 👍 85    🔁 8    💬 15    📌 0
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👏 Huge congrats to @audeber.bsky.social, group leader and head of our Molecular Diversity of Microbes lab, on being named a 2025 Vallee Scholar! Her pioneering work on ancestral immunity opens new perspectives for biomedical innovation. 🔬🌍

@valleefoundation.bsky.social

#Science #Immunity

02.09.2025 09:44 — 👍 75    🔁 13    💬 4    📌 1

Very happy to see this one out: doi.org/10.1093/molbev/msaf192
Here, we assessed the contribution of natural transformation to the acquisition of novel genes. See preprint thread. @molbioevol.bsky.social #microsky #evobio

27.08.2025 13:37 — 👍 63    🔁 29    💬 0    📌 0
graphical abstract of the article the extended mobility of plasmids

graphical abstract of the article the extended mobility of plasmids

Here's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...

23.07.2025 07:35 — 👍 184    🔁 93    💬 4    📌 9

Excited 🥳 to share our latest work on gut phages!
Big thanks to @epcrocha.bsky.social, Erick D, Camille d'H, @fplazaonate.bsky.social, Quentin LB, and all others involved for support and contributions! 🙌
Out in Cell Reports @cp-cellreports.bsky.social
doi.org/10.1016/j.ce...
Here's what we found 🤓

28.07.2025 08:41 — 👍 31    🔁 27    💬 1    📌 1

🦠🧍‍♀️From bacterial to human immunity.

We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social

www.science.org/doi/10.1126/...

24.07.2025 18:22 — 👍 262    🔁 122    💬 9    📌 11

@eloilittner is following 20 prominent accounts