@genesdev.bsky.social
G&D publishes high-quality research in molecular biology, cancer biology, development, neuroscience and related fields. In addition, G&D also publishes comprehensive Review Articles, Perspectives and Outlooks written by leading scientists.
RESEARCH COMMUNICATION: A critical affinity window for IgSF proteins DIP-Ξ± and Dpr10 is required for proper motor neuron arborization
By Lopez et al. and Richard Mann
β‘οΈ https://genesdev.cshlp.org/content/39/23-24/1426.full
#neuron #motorneuron #neurodevelopment #celladhesion #synapsis #Drosophila
RESEARCH PAPER: UPR deficiency leads to poor growth, aneuploidy, and a trade-off between ER and general proteostasis in yeast
By Bartolutti et al. and Gloria Brar
β‘οΈ https://genesdev.cshlp.org/content/39/23-24/1434.full
#aneuploidy #unfoldedproteinresponse #UPR #proteinfolding #proteostasis #yeast
RESEARCH COMMUNICATION: Igf2 regulates early postnatal DPP4+ preadipocyte pool expansion
By Altun et. al and Siegfried Ussar
β‘οΈ https://genesdev.cshlp.org/content/39/23-24/1414.full
#adipose #stemcells #adipogenesis #insulinsignaling #celldifferentiation #IGF
This monthβs cover of @genesdev.bsky.social has @j-muncie-vasic.bsky.socialβs embryos all in a row! Paper and commentary in the issue genesdev.cshlp.org/content/39/2...
01.12.2025 16:05 β π 8 π 3 π¬ 0 π 0
π¨ NEW ISSUE ALERT!!! π¨
New Outlook, Review, and Research articles online now at Genes & Development. Also in this issue, an In Memoriam on the life and work of John B. Gurdon.
Click on the link to learn more:
β‘οΈ https://genesdev.cshlp.org/content/39/23-24.toc
πG&D SPOTLIGHT π
REVIEW: RNA granules: functional compartments or incidental condensates?
By Andrea Putnam, Laura Thomas and Geraldine Seydoux
β‘οΈ https://genesdev.cshlp.org/content/37/9-10/354.abstract
#RNAmetabolism #RNAgranules #phaseseparation #RiboNucleoProteins #condensates
πG&D SPOTLIGHT π
RESEARCH PAPER: Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNAβRNA interactions
By Bonneau et al. and Elena Conti
β‘οΈ https://genesdev.cshlp.org/content/37/11-12/505.abstract
#ribonucleoproteins #granules #RNAinteractions #IDR #phaseseparation
πG&D SPOTLIGHT π
REVIEW: Cohesin in 3D: development, differentiation, and disease
By Maria SolΓ©-Ferran and Ana Losada
β‘οΈ https://genesdev.cshlp.org/content/39/11-12/679.abstract
#cohesin #chromatin #chromosome #development #cohesinopathy
πG&D SPOTLIGHT π
RESEARCH PAPER: Restrictor synergizes with Symplekin and PNUTS to terminate extragenic transcription
By Russo et al., and Gioacchino Natoli
β‘οΈ https://genesdev.cshlp.org/content/37/21-24/1017.abstract
#transcription #transcriptiontermination #restrictor #yeast #noncodingRNA
πG&D SPOTLIGHT π
REVIEW: CSTβPolΞ±/Primase: the second telomere maintenance machine
By Sarah Cai and Titia de Lange
β‘οΈ https://genesdev.cshlp.org/content/37/13-14/555.abstract
#telomere #telomerase #strandsynthesis #polymeraseβΊ #primase
π G&D SPOTLIGHT π
RESEARCH PAPER: Histone chaperones coupled to DNA replication and transcription control divergent chromatin elements to maintain cell fate
By Franklin et al., and Sihem Cheloufi
β‘οΈ https://genesdev.cshlp.org/content/39/9-10/652.abstract
#histones #transcription #replication
πG&D SPOTLIGHT π
RESEARCH PAPER: MRNβCtIP, EXO1, and DNA2βWRN/BLM act bidirectionally to process DNA gaps in PARPi-treated cells without strand cleavage
By Seppa et al., and Alessandro Vindigni
β‘οΈ https://genesdev.cshlp.org/content/39/9-10/582.abstract
#DNArepair #BRCA1 #nucleases #PARP #cancer
πG&D SPOTLIGHT π
RESEARCH PAPER: Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCORβncPRC1.1
By Wolf van der Meer et al., Jeroen Demmers, Yaser Atlasi and Peter Verrijzer
β‘οΈ https://genesdev.cshlp.org/content/39/5-6/401.abstract
#neurodevelopment #epigenetics #polycomb
π G&D SPOTLIGHT π
RESEARCH PAPER: ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease
By Song et al. and Wei Gu
β‘οΈ https://genesdev.cshlp.org/content/37/5-6/204.abstract
#huntingtonsdisease #ferroptosis #huntingtin #oxidativestress #ROS
IN MEMORIAM: A totipotent embryologist: John B. Gurdon
(1933β2025)
By Thoru Pederson
β‘οΈ https://tinyurl.com/gd353471OA
*Photo courtesy of the Cold Spring Harbor Laboratory Archives.
OUTLOOK: End of the line: a kinetic ruler model for poly(A) tail termination
By Anita Corbett
β‘οΈ https://genesdev.cshlp.org/content/39/21-22/1267.full
Learn more here:
β‘οΈ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
RESEARCH PAPER: A cell type-specific surveillance complex represses cryptic promoters during differentiation in an adult stem cell lineage
By Matias et al. and Margaret Fuller
β‘οΈ https://genesdev.cshlp.org/content/39/21-22/1318.abstract
#chromatin #transcription #Drosophila #stemcells #germline
RESEARCH PAPER: A kinetic ruler controls mRNA poly(A) tail length
By Gabs et al. and Matti Turtola
β‘οΈ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
OUTLOOK: The two faces of MyoD: repressor and activator of gene expression during myogenesis
By Carmen Birchmeier
β‘οΈ https://genesdev.cshlp.org/content/39/21-22/1269.full
Learn more here:
β‘οΈ https://genesdev.cshlp.org/content/39/21-22/1299.abstract
#transcription #muscle #stemcells #openaccess
RESEARCH PAPER: Dominant-negative effects of Weaver syndrome-associated EZH2 variants
By Deevy et al., Eric Conway and Adrian Bracken
β‘οΈ https://genesdev.cshlp.org/content/39/21-22/1355.full
Eric Conway
Adrian Bracken
#weaversyndrome #ezh2 #polycomb #mutation #congenitaldisorder #onthecover
REVIEW: Multifaceted role of the vitamin B6 pathway in cancer: metabolism, immune interaction, and temporal and spatial regulation
By Mishra et al. and Lingbo Zhang
β‘οΈ https://genesdev.cshlp.org/content/39/21-22/1271.abstract
#cancer #metabolism #vitamin #cancertherapy #cancermetabolism #immune
RESEARCH PAPER: Mouse cortical cellular diversification through lineage progression of radial glia
By Yang et al., and Xiaosu Li
β‘οΈ https://genesdev.cshlp.org/content/39/21-22/1338.abstract
#glia #braindevelopment #neuron #neurodevelopment #neuronalprogenitor #neuralstemcell #epigenetics
RESEARCH PAPER: MYOD represses gene expression from non-E-box motifs
By Nicoletti, Massenet et al., Luca Caputo and Pier Lorenzo Puri
β‘οΈ https://genesdev.cshlp.org/content/39/21-22/1299.abstract
#transcription #trancriptionfactor #epigenetics #muscle #stemcells
π₯ G&D Tapes π₯
G&D author, Haoming Yu tells us about their new study in #genesdev that uses epigenetic editing to probe the role of H3K4me3 at intergenic regulatory elements.
Learn more here:
β‘οΈ https://genesdev.cshlp.org/content/39/21-22/1290.full
Bluma Lesch
@haomingyu.bsky.social
RESEARCH COMMUNICATION: H3K4me3 amplifies transcription at intergenic active regulatory elements
By Yu et. al and Bluma Lesch
β‘οΈ https://genesdev.cshlp.org/content/39/21-22/1290.full
Bluma Lesch
@haomingyu.bsky.social
#transcription #epigenetics #histones #histonePTMs #methylation #enhancers
π¨ NEW ISSUE ALERT!!! π¨
New Outlook, Review and Research articles online now at Genes & Development.
Click on the link to learn more:
β‘οΈ https://genesdev.cshlp.org/content/39/21-22.toc
RESOURCE/METHODOLOGY: A genome-wide, CRISPR-based screen reveals new requirements for translation initiation and ubiquitination in driving adipogenic fate change
By Turn et al. and Peter Jackson
Learn more here:
β‘οΈ https://genesdev.cshlp.org/content/39/19-20/1241.abstract
RESEARCH PAPER: A noncanonical Pol III-dependent, Microprocessor-independent biogenesis pathway generates a germline-enriched miRNA family
By Sakhawala et al. and Katherine McJunkin
Learn more here:
β‘οΈ https://genesdev.cshlp.org/content/39/19-20/1198.abstract
RESEARCH PAPER: SUMO2 promotes histone pre-mRNA processing by stabilizing histone locus body interactions and facilitating U7 snRNP assembly
By He et al. and Michael Matunis
Learn more here:
β‘οΈ https://genesdev.cshlp.org/content/39/19-20/1182.abstract
RESEARCH PAPER: Condensation of human OAS proteins initiates diverse antiviral activities in response to West Nile virus
By Briggs et al. and James Burke
Learn more here:
β‘οΈ https://genesdev.cshlp.org/content/39/19-20/1162.abstract
