@genesdev.bsky.social
G&D publishes high-quality research in molecular biology, cancer biology, development, neuroscience and related fields. In addition, G&D also publishes comprehensive Review Articles, Perspectives and Outlooks written by leading scientists.
NEW ISSUE ALERT!!!
Inspired by the 2025 CSHL Symposium on Aging & Senescence, this issue features a collection of Outlook, Perspective, and Review articles on the impact of aging on metabolism, immunity, reproductive health & cancer.
Online now:
β‘οΈ genesdev.cshlp.org/content/39/1...
In this study, Tran et al. show that Notch signaling controls the switch from neuronal fates to oligodendrocyte fatesβin response to Sonic hedgehog signalingβduring late embryogenesis.
Learn more here:
β‘οΈ tinyurl.com/gd352555
Excited to share that our latest story on Restrictor is out now in @genesdev.bsky.social!! Big thank you to my fellow co-first author Hanneke, Karen @adelmanlab.bsky.social and co-authors Nathalie and Allison!
14.07.2025 14:57 β π 30 π 12 π¬ 1 π 0Happy to share this paper! We uncovered that good 5' splice sites protect against ZC3H4/Restrictor's promiscuous role, and that its role is to suppress elongation and indirectly cause termination. Looking forward to learning more about this protein in the future!
18.07.2025 08:33 β π 30 π 9 π¬ 2 π 1
In this study, Perry et al. report that TEAD performs YAP/TAZ-dependent and -independent functions by switching interacting partners during brain development and neuronal lineage progression.
Learn more here:
β‘οΈ tinyurl.com/gd352632
Studying ovarian aging and its health impacts: modern tools and approaches
Excited to see this new review piece that we wrote together with Jennifer Garrison and Alison Kochersberger on the modern tools and approaches to study #ovarian #aging out this week at @genesdev.bsky.social!
genesdev.cshlp.org/content/earl... #GeroSky #WomensHealth π§ͺπ§¬
A π§΅1/3
In this study, Mimoso et al. show that Restrictor serves as a transcriptional safeguard that suppresses the spurious transcription of non-coding RNAs, while preserving mRNA transcription.
Learn more here:
β‘οΈ tinyurl.com/gd352654
In this Outlook, Rodeheffer discusses this study and highlights the functional importance of the ETS family of transcription factors in lineage decisions and cell function. #OpenAccess
Read the Outlook:
β‘οΈ tinyurl.com/gd352966
In this study, Xue et al. identify a distal enhancer that interacts with transcription factor ETV4 to control brown adipose thermogenesis, with implications for metabolic diseases like obesity and diabetes. #OpenAccess
Learn more here:
β‘οΈ tinyurl.com/gd352748
π½οΈ G&D Tapes π½οΈ
G&D author, Noah Helton tells us about their new study in #genesdev, revealing an intriguing link between stress granule formation and the integrated stress response. #OpenAccess @smslmoon.bsky.social
Read the full story here:
β‘οΈ tinyurl.com/gd352899
In this study, Helton et al. explore the link between stress-induced gene expression and mRNA condensation into stress granules. #OpenAccess @smslmoon.bsky.social
Learn more here:
β‘οΈ tinyurl.com/gd352899
G&Dβs Editor-In-Chief, Professor Andy Dillin is attending the #GLIA2025 in Marseille.
If youβd like to share your work with us or learn about the journal, feel free to drop by or reach out to dillin@berkeley.edu
@genesdev.bsky.social @dillinlab.bsky.social
In this Review, Bodur et al. discuss the intricacies of neural control of leptin signaling and its implications for food intake, body weight, metabolism, and disease. #OpenAccess
Learn more here:
β‘οΈ tinyurl.com/gd352550
π½οΈ G&D Tapes π½οΈ
G&D authors tell us about the recent study by Chocarro-Calvo et al. in #genesdev describing the metabolic cross-talk between melanoma and adipose, and the influence of nutrients on melanoma progression.
@achocarro-calvo.bsky.social
Learn more here:
β‘οΈ tinyurl.com/gd351985
NEW ISSUE ALERT!!!
Check out the new Outlook, Review and Research Papers online now at Genes & Development.
Click on the link for more:
β‘οΈ genesdev.cshlp.org/content/curr...
In this study, Magesh et al. describe the metabolic consequences of breast cancer-associated, net gain aneuploidy on mammary epithelial cells, identifying dependencies to improve chemotherapeutic response. #OpenAccess
Learn more here:
β‘οΈ tinyurl.com/gd352512
In this Outlook, Huang et al. highlight the heterogeneity of pineoblastoma's pathogenic mechanisms with implications for therapeutic interventions. #OpenAccess
Read the Outlook:
β‘οΈ tinyurl.com/gd352932
In this study, Fraire et al. elucidate the impact of the loss of microRNA processing on pineoblastoma formation, illustrating parallel mechanisms that can be leveraged into combinatorial anti-tumor therapies.
Learn more here:
β‘οΈ tinyurl.com/gd352485
π½οΈ G&D Tapes π½οΈ
G&D author Aitana Verdu Schlie tells us about their new work in #GenesDev about CDK4's role during development, with mutations causing microcephaly and growth defects. #OpenAccess @lukastamayo.bsky.social @aitanavs.bsky.social
Read the full story here:
β‘οΈ tinyurl.com/gd352311
In this study, Dehmer et al. show that the USP11/TCEAL1 complex buffers TFIIS's function in RNAPII backtracking, promoting transcription elongation and oncogenic transcription in neuroblastoma.
Learn more here:
β‘οΈ tinyurl.com/gd352166
In this study, Mouginot et al. describe the formation and function of meta-domainsβmegabase-range chromatin contactsβthat underpin the complexity and specificity of neuron-specific genome architecture and gene expression.
Learn more here:
β‘οΈ tinyurl.com/gd352646
In this study, Chen et al. describe two distinct mechanisms that control Ξ²-catenin levels underlying MEK-mediated proliferation in neuroglial cells, important during NF1-loss or BRAF rearrangement in pediatric gliomas. #openaccess
Learn more here:
β‘οΈ tinyurl.com/gd352508
In this Review, SolΓ©-Ferran and Losada discuss the mechanisms by which the cohesin complex facilitates chromatin looping and sister chromatid cohesion and their implications for embryonic development and cohesinopathies. #OpenAccess
Learn more here:
β‘οΈ tinyurl.com/gd352671
G&D Executive Editor, Dr. Eric Sawey is attending @keystonesymposia.bsky.social #KSNeuroImmune25 in Whistler! If youβre in town, stop by to discuss your work or reach out to sawey@cshl.edu to set up a good time to chat.
06.06.2025 14:29 β π 3 π 1 π¬ 0 π 0
Great to see this published @genesdev.bsky.social. Evidence that enhancers can activate a bystander gene in an adjacent TAD, and that cohesin facilitates this. @uoe-igc.bsky.social.
pubmed.ncbi.nlm.nih.gov/40436628/
π€©π€©π€© check out those chroms! π€©π€©π€©
a tribute to our lab's love of knitting and chromosomes
NEW ISSUE ALERT!!!
Check out the new Research Papers, Review, and Outlook Articles online now at Genes & Development.
Click on the link for more:
β‘οΈ genesdev.cshlp.org/content/curr...
The G&D Editors will be at the CSHL Symposium this week, on Senescence and Aging.
#cshlsymp25 #cshlmeetings
To tell us about your work or learn more about publishing with us, book a 1-on-1 session here:
β‘οΈ doodle.com/meeting/part...
In this study, Franklin et al. show that histone chaperones, like the transcription-coupled SPT6 and the replication-coupled CAF-1, control cell differentiation and lineage choice through distinct mechanisms. #OpenAccess
Learn more here:
β‘οΈ tinyurl.com/gd352316
In this study, Verdu Schlie et al. elucidate the cell cycle kinase, CDK4's key role in mitosis-independent, G1-to-S transition and cell proliferation during development. #OpenAccess
Learn more here:
β‘οΈ tinyurl.com/gd352311
