@genesdev.bsky.social
G&D publishes high-quality research in molecular biology, cancer biology, development, neuroscience and related fields. In addition, G&D also publishes comprehensive Review Articles, Perspectives and Outlooks written by leading scientists.
RESEARCH PAPER: ERRγ impedes neuroendocrine prostate cancer development
By Li et al., and Vincent Giguère
➡️ https://genesdev.cshlp.org/content/40/3-4/160.abstract
Vincent Giguère
#prostatecancer #neuroendocrine #cancertherapeutics #nuclearreceptor
🚨 NEW ISSUE ALERT!!! 🚨
New Outlook, Review, and Research articles online now at Genes & Development.
Click on the link to learn more:
➡️ https://genesdev.cshlp.org/content/40/3-4.toc
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Hunchback functions in the post-mitotic larval MDN to restrict axon outgrowth, synapse formation, and backward locomotion
By Lee et al., and Chris Doe
➡️ https://genesdev.cshlp.org/content/early/2025/11/20/gad.353223.125.abstract
#neuron #drosophila #locomotion
🎙️ G&D Voices: Author Lori Sussel 🎙️
From submission to publication, our authors’ experiences matter.
Here’s what one of our authors had to say about publishing with G&D.
Learn more about publishing with G&D here:
➡️ https://genesdev.cshlp.org
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Potent synthetic lethality between PLK1 and EYA family inhibitors in tumors of the central and peripheral nervous systems
By Nelson et al., and Hilda Pickett
➡️https://genesdev.cshlp.org/content/early/2025/11/20/gad.353271.125.abstract
#cancertherapy #glioblastoma
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: B-lineage commitment is dependent on a reversible epigenetic switch
By Tingvall-Gustafsson et al., and Mikael Sigvardsson
➡️ https://genesdev.cshlp.org/content/early/2025/11/20/gad.353002.125.abstract
#hematopoiesis #Bcell #transcriptionfactor #epigenetics
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
By LaVigne et al., and Joshua Mendell
➡️ https://genesdev.cshlp.org/content/early/2025/11/10/gad.353138.125.abstract
Josh Mendell HHMI
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: SOX2 phosphorylation during mitosis limits genomic damage
By Williams et al., and Steven Pollard
➡️ https://genesdev.cshlp.org/content/early/2025/11/10/gad.352664.125.abstract
#sox2 #chromatin #neural #mitosis #stemcells #phosphorylation
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RESEARCH PAPER: Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer
By Shao et al., and Maureen Murphy The Wistar Institute
➡️ https://genesdev.cshlp.org/content/early/2025/11/05/gad.352953.125.abstract
#ovariancancer #p53
Explore emerging research with field leaders Keystone Symposia #IsletBiology & #Diabetes : #BetaCell Compensation, Failure & Recovery, this March in Breckenridge! #KSDiabetes26
For more info:
➡️ https://hubs.la/Q03X7Ckz0
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: ERRγ impedes neuroendocrine prostate cancer development
By Li et al., and Vincent Giguère
➡️ https://genesdev.cshlp.org/content/early/2025/10/29/gad.353024.125.abstract
#prostatecancer #neuroendocrine #cancertherapeutics #nuclearreceptor
Explore emerging research with field leaders at Keystone Symposia RNA Modifications: Bridging Biological Function and Therapeutic Potential, this March in Keystone! #KSRNAMod26
For more info:
➡️ https://hubs.la/Q03-NnlC0
OUTLOOK: Rewiring gene circuits to dissect oscillatory signaling dynamics
By Marek van Oostrom and Katharina Sonnen
➡️ https://genesdev.cshlp.org/content/40/1-2/1.full
Read the full story:
➡️ https://genesdev.cshlp.org/content/40/1-2/124.full
Ina Sonnen Hubrecht Institute
#optogenetic #segmentation
RESOURCE/METHODOLOGY: Synchronization of the segmentation clock using synthetic cell–cell signaling
By Akihiro Isomura, Daisuke Asanuma, and Ryoichiro Kageyama
➡️ https://genesdev.cshlp.org/content/40/1-2/124.full
#optogenetic #signaling #segmentation #notch
RESEARCH PAPER: Longevity-promoting mitochondrial unfolded protein response activation requires elements of the PeBoW complex
By Adedoja et al., Armen Yerevanian, and Alexander Soukas
➡️ https://genesdev.cshlp.org/content/40/1-2/110.abstract
#mitochondria #longevity #Celegans #EJC
RESEARCH PAPER: Dorsal determinant Hwa stabilizes β-catenin through direct inhibition of GSK3
By Ji et al., and Feng Cong
➡️ https://genesdev.cshlp.org/content/40/1-2/56.abstract
#development #signaling #kinase #WNT
RESEARCH PAPER: An intrinsically disordered region of Drosha selectively promotes miRNA biogenesis independent of tissue-specific Microprocessor condensates
By Yang et al., and Katherine McJunkin
➡️ https://genesdev.cshlp.org/content/40/1-2/26.abstract
#IDR #miRNA #Microprocessor #smallRNA
REVIEW: Mutant p53: evolving perspectives
By Gizem Efe, Katherine Cunningham, Anil K. Rustgi, Carol Prives, James J. Manfredi, and Francisco J. Sánchez-Rivera
➡️ https://genesdev.cshlp.org/content/40/1-2/43.full
#cancer #mutation #p53
📽 G&D Tapes 📽
G&D Author, Alexandra Bergfort, tells us about their new study in #genesdev showing how the EJC coordinates splicing of exon blocks
Learn more:
➡️ https://genesdev.cshlp.org/content/40/1-2/94.full
Karla Neugebauer Alexandra Bergfort
Yale Center for RNA Science and Medicine
#splicing
RESEARCH PAPER: The exon junction complex coordinates the cotranscriptional inclusion of blocks of neighboring exons
By Bergfort et al., and Karla Neugebauer
➡️ https://genesdev.cshlp.org/content/40/1-2/94.full
Karla Neugebauer Alexandra Bergfort
Yale Center for RNA Science and Medicine
#splicing
G+D together with JHU worked to put together this cool video describing our latest work! Check it out!
07.01.2026 23:55 — 👍 5 🔁 5 💬 1 📌 0📽 G&D Tapes 📽
G&D Author, Christina McNerney, tells us about their new study in #genesdev showing how enzyme DIO3 coordinates photoreceptor development.
Read the full story here:
➡️ https://genesdev.cshlp.org/content/40/1-2/70.full
Christina McNerney Bob Johnston Johns Hopkins University
#vision
RESEARCH PAPER: DIO3 coordinates photoreceptor development timing and fate stability in human retinal organoids
By McNerney et al., and Robert Johnston, Jr.
➡️ https://genesdev.cshlp.org/content/40/1-2/70.full
Bob Johnston Christina McNerney Johns Hopkins University
#photoreceptor #hormone #neurons
RESEARCH PAPER: Histone modification cross-talk and protein complex diversification confer plasticity to Polycomb repression
By Bonnet et al., and Jürg Müller
➡️ https://genesdev.cshlp.org/content/40/1-2/43.full
Max Planck Institute of Biochemistry
#polycomb #histone #chromatin #drosophila
🚨 NEW ISSUE ALERT!!! 🚨
New Outlook, Review, and Research articles online now at Genes & Development.
Click on the link to learn more:
➡️ https://genesdev.cshlp.org/content/40/1-2.toc
Wrapping up G&D 2025 on a high note!!!
Stay tuned for another great year of exciting research.
HAPPY NEW YEAR!!!
⏪ G&D RECAP ⏪
🗓️ December 2025
RESEARCH PAPER: Multiple human enhancer RNAs contain long translated open reading frames
By Vlasov et al. and James Manley
➡️ https://genesdev.cshlp.org/content/39/23-24/1468.full
#protein #translation #enhancerRNA #chromatin #DNAdamage #RNAprocessing #nucleus
⏪ G&D RECAP ⏪
🗓️ November 2025
OUTLOOK: End of the line: a kinetic ruler model for poly(A) tail termination
By Anita Corbett
➡️ https://genesdev.cshlp.org/content/39/21-22/1267.full
Learn more here:
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #ribonucleoprotein
⏪ G&D RECAP ⏪
🗓️ November 2025
RESEARCH PAPER: A kinetic ruler controls mRNA poly(A) tail length
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
⏪ G&D RECAP ⏪
🗓️ October 2025
RESEARCH COMMUNICATION: Structural basis of nucleosome recognition by the conserved Dsup & HMGN nucleosome-binding motif
By Alegrio-Louro et al. and Andres Leschziner
➡️ https://genesdev.cshlp.org/content/39/19-20/1155.full
#proteininteractions #proteinstructure #cryoEM
