Tissue Engineering Research Group RCSI

Just back from Wuhan and TERMIS Asia Pacific conference with our @tissueengdublin.bsky.social team #TERGonTour

Great to have our latest paper published in Biomaterials on tissue engineering strategies for peridontal & endodontic regeneration. A really nice collaboration between @tissueengdublin.bsky.social & our dental colleagues. authors.elsevier.com/sd/article/S...

Head of TERG @fjobrien.bsky.social discussing PPI in research with Clarinda Cerejo and Caitlin Rich as part of a special edition of their award winning podcast 'Not Just Patients!' at part of the launch of the National PPI Festival that took place in RCSI over the past 2 days.
@rcsi.bsky.social

Great to have Dr Claudio Intini in TERG today to deliver a guest seminar on his research to date in orthopaedics and his new research focus at the Universita degli Studi di Cagliari!
@fjobrien.bsky.social

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix This study demonstrates that the dual delivery of BMP-2/-7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP-2 or BMP-7 cmRNAs, the combi...

Read it here: advanced.onlinelibrary.wiley.com/doi/full/10....

Congratulations to all involved on TERG's newest article in collaboration with @erbalmayor.bsky.social 'Synergistic Osteogenesis After Co-Administration of cmRNAs Encoding BMP-2 and BMP-7 Utilizing a Transcript-Activated Matrix', published in Advanced Functional Materials!
@fjobrien.bsky.social

A great first day at the International Congress on Biomaterials for Wound Healing for the TERG team yesterday!
#ICBWH2025
@fjobrien.bsky.social
@markodobricic.bsky.social
@rcsi.bsky.social

Join TERG! We're looking for a postdoctoral researcher to join our project on advanced therapy medical products for cartilage regeneration!
Follow the links to find out more!
my.corehr.com/pls/coreport...

www.linkedin.com/jobs/view/42...

@fjobrien.bsky.social

Members of TERG headed to the Sorbonne this week to discuss a new collaborative project on #TReg cells and immunotherapy with Francisco Fernandes and Makoto Miyara!
Travel funded by @researchireland.ie #Ulysses

Great example of research that would not have occurred without the unique interdisciplinary environment of @ambercentre.bsky.social A real team effort between @tissueengdublin.bsky.social researchers led by research fellow Ian Woods and 2D materials scientists from Prof Valeria Nicolosi’s lab.

Publication in Advanced Science from Dr Ian Woods on the development of spatially-organised electroconductive neurotrophic scaffolds for repair of neurotrauma! Facilitated by joint funding from the Research Ireland AMBER Centre and the IRFU Charitable Trust, read the press release and paper below!

It was wonderful to have Tracy Robson with us this morning to speak about her rules for a successful career in STEM and her own scientific and academic journey, kicking off our Women in Academia Workshop running today and tomorrow as part of the ongoing REGENEU collaboration!
@fjobrien.bsky.social

RCSI researchers awarded over €1.9m in Research Ireland Pathway Programme funding Three early-career researchers at RCSI have secured a combined €1.94 million in funding from Research Ireland’s prestigious Pathway Programme. More ...

Three of RCSI’s early career researchers have secured €1.94 million in funding under Research Ireland’s Pathway Programme.

The funding aims to support the next generation of independent research leaders in Ireland.

Read more ⬇ www.rcsi.com/dublin/news-...

#RCSIdiscover

Congratulations Ian Woods!! 🥳🥳

Digital medical illustration showing a glowing red human heart within a transparent upper torso, emphasising the cardiovascular system. The RCSI University of Medicine and Health Sciences logo appears in the upper right corner, and the "RCSI Discover" brand is displayed in the lower right corner on a red banner.

A new RCSI study is the first to simulate catheter tracking in digital patient anatomies for TAVR.

Researchers found high tracking forces linked to areas of tissue stress - insights that could guide safer treatment.

Read the paper ➡️ doi.org/10.1016/j.co...

#RCSIdiscover

A biomimetic reinforced type I/II collagen and hyaluronic acid scaffold in combination with a chondral biomaterial fixation technique for large articular cartilage defect repair: A pilot pre-clinical ... Successfully repairing large articular cartilage defects remain an unmet clinical challenge. Our lab has previously developed a biomimetic mechanicall…

New paper from TERG published in the International Journal of Biological Macromolecules today on the use of biomimetic reinforced scaffolds in combination with a novel suturing technique for large articular cartilage defects! Read it now: www.sciencedirect.com/science/arti...
@fjobrien.bsky.social

Delighted to welcome @garryduffy.bsky.social back to RCSI & as new Prof. of Anatomy in Dept. of Anatomy & Regen Med.
He brings a wealth of research experience in advanced biomaterials and medical technologies and his work is a great addition to @tissueengdublin.bsky.social. Exciting times ahead.

Congratulations to our latest PhD graduates: Liam Leahy, Stefanie Croghan, Tara McGuire and Michael Joyce (in absentia) who graduated yesterday! 🥳
Congratulations to supervisors @fjobrien.bsky.social, Adrian Dervan and Niall Davis!

Congratulations to the RCSI graduates who received degrees of MSc, MPharm, MCh, MD and PhD at our #RCSIConferring yesterday!

We were delighted to commemorate this momentous day with you.

Read more ➡️ www.rcsi.com/dublin/news-...

Neuroprotective Riluzole-Releasing Electrospun Implants for Spinal Cord Injury Spinal cord injury (SCI) results in paralysis, driven partly by widespread glutamate-induced secondary excitotoxic neuronal cell death in and around the injury site. While there is no curative treatment, the standard of care often requires interventive decompression surgery and repair of the damaged dura mater close to the injury locus using dural substitutes. Such intervention provides an opportunity for early and local delivery of therapeutics directly to the injured cord via a drug-loaded synthetic dural substitute for localized pharmacological therapy. Riluzole, a glutamate-release inhibitor, has shown neuroprotective potential in patients with traumatic SCI, and therefore, this study aimed to develop an electrospun riluzole-loaded synthetic dural substitute patch suitable for the treatment of glutamate-induced injury in neurons. A glutamate-induced excitotoxicity was optimized in SH-SY5Y cells by exploring the effect of glutamate concentration and exposure duration. The most effective timing for administering riluzole was found to be at the onset of glutamate release as this helped to limit extended periods of glutamate-induced excitotoxic cell death. Riluzole-loaded patches were prepared by using blend electrospinning. Physicochemical characterization of the patches showed the successful encapsulation of riluzole within polycaprolactone fibers. A drug release study showed an initial burst release of riluzole within the first 24 h, followed by a sustained release of the drug over 52 days to up to approximately 400 μg released for the highest loading of riluzole within fiber patches. Finally, riluzole eluted from electrospun fibers remained pharmacologically active and was capable of counteracting glutamate-induced excitotoxicity in SH-SY5Y cells, suggesting the clinical potential of riluzole-loaded dural substitutes in counteracting the effects of secondary injury in the injured spinal cord.

Congratulations to Mathilde Ullrich, Bhavana Pulipaka, Adrian Dervan and @fjobrien.bsky.social on publication of 'Neuroprotective Riluzole-Releasing Electrospun Implants for Spinal Cord Injury' in Molecular Pharmaceutics today! 🥳
Read it below:
pubs.acs.org/doi/full/10....

Congratulations to all involved on the article led by @optimisticbio.bsky.social
@fjobrien.bsky.social
@rcsi.bsky.social

Biomimetic Scaffolds Enhance iPSC Astrocyte Progenitor Angiogenic, Immunomodulatory, and Neurotrophic Capacity in a Stiffness and Matrix‐Dependent Manner for Spinal Cord Repair Applications Through tuning biomimetic scaffold stiffness and matrix composition the reparative capacity of astrocyte progenitors is enhanced. Soft, collagen-IV/fibronectin-functionalized scaffolds promote progen....

'Biomimetic Scaffolds Enhance iPSC Astrocyte Progenitor Angiogenic, Immunomodulatory, and Neurotrophic Capacity in a Stiffness and Matrix-Dependent Manner for Spinal Cord Repair Applications' is online in Advanced Healthcare Materials!
Read it: advanced.onlinelibrary.wiley.com/doi/10.1002/...

Researchers and individuals impacted by EB collaborating.

Dr Marko Dobricic (RCSI)

Dr Hilal Kirpik (Maynooth University)

Professor Des Tobin (UCD)

Debra co-funded researchers from @maynoothuniversity.ie, @rcsi.bsky.social and @ucddublin.bsky.social shared their research at our recent EB Expert panel workshop.

Powerful to see researchers engaging with those impacted by #EB, ensuring their work is relevant and shaped by lived experiences.

#PPI

Antibiotic‐Loaded Polymer‐Calcium Phosphate Scaffold for Treating Orthopedic Device‐Related Infection in a Rabbit Segmental Bone Defect Model Treatment of orthopedic device-related infection (ORDI) generally requires a combination of medical and surgical interventions for successful treatment outcomes. Many cases are treated with a two-sta....

'Antibiotic-Loaded Polymer-Calcium Phosphate Scaffold for Treating Orthopedic Device-Related Infection in a Rabbit Segmental Bone Defect Model' has now been published in the Journal of Biomedical Materials Research Part A!
Read it: onlinelibrary.wiley.com/doi/10.1002/...
@fjobrien.bsky.social

Biomaterial scaffold-based gene delivery for the repair of complex wounds: Challenges, progress, and future perspectives This review explores recent progress in scaffold-based gene delivery, identifies key barriers to clinical application, and discusses future directions that could bring this cutting-edge approach to pa...

Huge congratulations to Juan Carlos Palomeque on the publication of his review 'Biomaterial scaffold-based gene delivery for the repair of complex wounds: Challenges, progress, and future perspectives' in Cell Biomaterials today! 🥳
Read it now: www.cell.com/cell-biomate...
@fjobrien.bsky.social

Video explainer of the new Patient Stem Cell Discovery Core in RCSI @rcsi.bsky.social & Beaumont Hospital.

With patients like David Crosby we aim to find treatments for pulmonary fibrosis and cystic fibrosis.
🧪
#CureIPF
#iPSC
#CF

Supporting work by
@erc.europa.eu
@researchireland.bsky.social
HRB

Great to have TY students in TERG today as part of the @ambercentre.bsky.social programme, where they learned about our expertise in 3D printing, melt electrowriting, scaffold fabrication and tissue culture, as well as our research on wound healing, nerve repair, cancer, and meniscus repair!

Frontiers | Circulating miRNAs are associated with successful bone regeneration

Newest article from @fjobrien.bsky.social has now been published in Frontiers in Bioengineering and Biotechnology!
Read the article here: www.frontiersin.org/journals/bio...

Who knew a TV show could spark groundbreaking #ebresearch in Ireland?

After hearing Claudia Scanlon’s #EB story on @latelateshow.rte.ie, @fjobrien.bsky.social and team @rcsi.bsky.social @tissueengdublin.bsky.social are developing a patch to improve wound healing.

bit.ly/RCSI-gene-therapy-research

We're looking forward to attending the opening soon!