Grainger Lab

A family of linear plasmid phages that detect a quorum-sensing autoinducer exists in multiple bacterial species Temperate phages oscillate between lysogeny, a genomic maintenance state within a bacterial host, and lytic replication, in which the host is killed, and newly made phage particles are released. Succe...

'We show that the VqmAj homologs can indeed detect (host autoinducer) DPO and, in response, activate the lytic pathway. Our observation indicates that jVP882 is a member of a large family of globally-dispersed quorum-sensing-responsive temperate phages.'
www.biorxiv.org/content/10.1...

01.08.2025 12:28 — 👍 3    🔁 2    💬 0    📌 0

📢 Dear lovers of prokaryotic chromosomes:
Registration for the Biology & Physics of Chromosomes meeting has been extended until 7 August ⏳.
Join us!
@biophychrom.bsky.social
@danielabarilla.bsky.social
@damelab.bsky.social
@graingerlab.bsky.social
@biochemsoc.bsky.social
#microsky

30.07.2025 10:20 — 👍 4    🔁 7    💬 0    📌 0

Talk slots full but we can take late breaking poster abstracts until August 7th. Hope to see you in York to hear about your chromosome story 🧬🦠🧫

www.eventsforce.net/biochemsoc/f...

@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social

25.07.2025 12:14 — 👍 9    🔁 8    💬 0    📌 1

Left: Compound-promoter interaction network. Fifty-three significant compound-promoter interactions are shown as edges in a Sankey diagram connecting the compounds (left, source nodes) to the promoters (right, target nodes). Edge thickness represents mean Z-scores (n = 8), while node size represents the total number of interactions. Right: Proposed model for the molecular mechanism of caffeine-ciprofloxacin antagonism. Caffeine triggers expression of MicF small RNA in a Rob-dependent manner, which then binds to the 5′-UTR of ompF mRNA to inhibit and decrease OmpF protein levels. This ultimately prevents ciprofloxacin from entering the cell, resulting in caffeine-ciprofloxacin antagonism

How are bacterial transport machineries regulated by external cues? @brochadolab.bsky.social &co identify environmental chemicals that regulate #transporter transcription, identifying the TF Rob as a key modulator of #EffluxPump expression in #Ecoli #AMR @plosbiology.org 🧪 plos.io/46pUM9Q

23.07.2025 09:20 — 👍 34    🔁 13    💬 1    📌 0

Poster advertising the Biology and Physics of Prokaryotic Chromosomes conference that will be held in York, 16-19 September 2025.

Just few days left to register for this chromosome biology fête! 🧬🧬🧬

⏳📆 16 July

www.eventsforce.net/biochemsoc/f...

@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social

14.07.2025 12:47 — 👍 11    🔁 9    💬 0    📌 0

Flyer advertising The Biology and Physics of Prokaryotic Chromosome conference that will be held in York, 16-19 September 2025.

Chromosome Enthusiasts, join us at The Biology & Physics of Prokaryotic Chromosomes 🧬! Friendly community, fantastic speakers line-up, grant writing session for ECRs. Early-bird deadline approaching soon.
@damelab.bsky.social @vslioy.bsky.social @graingerlab.bsky.social @biophychrom.bsky.social

11.06.2025 10:52 — 👍 10    🔁 9    💬 1    📌 0

West African–South American pandemic Vibrio cholerae encodes multiple distinct phage defence systems - Nature Microbiology The West African–South American lineage of Vibrio cholerae contains multiple distinct anti-phage defence systems that provide resistance to various phage families, including vibriophage ICP1, a key pr...

🚨 Out now!

West African South American pandemic Vibrio cholerae encodes multiple distinct phage defence systems

#MicroSky 🦠 #Phage @mblokesch.bsky.social

www.nature.com/articles/s41...

23.05.2025 15:38 — 👍 22    🔁 8    💬 0    📌 0

Join us in York for the Biology & Physics of Prokaryotic Chromosomes! 🧬 #Microsky #Archaeasky

www.biochemistry.org/events-and-t...
@biochemsoc.bsky.social
@damelab.bsky.social @graingerlab.bsky.social @vslioy.bsky.social

15.05.2025 20:00 — 👍 22    🔁 6    💬 0    📌 1

These Tiny Magnetic Bacteria Act Like a Single Body – And Could Explain the Origins of Complex Life Tiny magnetic bacteria that live in tightly bound groups are showing scientists how life might have evolved complex, multicellular forms. These rare bacteria can’t survive alone – they depend on one a...

Fascinating new PLoS Biology paper from George Schaible et al in the Hatzenpichler Lab at Montana State

“𝘈𝘴 𝘵𝘩𝘦 𝘰𝘯𝘭𝘺 𝘦𝘹𝘢𝘮𝘱𝘭𝘦 𝘰𝘧 𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘢 𝘵𝘩𝘢𝘵 𝘦𝘹𝘩𝘪𝘣𝘪𝘵 𝘰𝘣𝘭𝘪𝘨𝘢𝘵𝘦 𝘮𝘶𝘭𝘵𝘪𝘤𝘦𝘭𝘭𝘶𝘭𝘢𝘳𝘪𝘵𝘺, 𝘔𝘔𝘉 𝘱𝘳𝘰𝘷𝘪𝘥𝘦 𝘢𝘯 𝘪𝘮𝘱𝘰𝘳𝘵𝘢𝘯𝘵 𝘦𝘹𝘢𝘮𝘱𝘭𝘦 𝘰𝘧 𝘱𝘰𝘴𝘴𝘪𝘣𝘭𝘦 𝘮𝘦𝘤𝘩𝘢𝘯𝘪𝘴𝘮𝘴 𝘣𝘦𝘩𝘪𝘯𝘥 𝘵𝘩𝘪𝘴 𝘱𝘳𝘰𝘧𝘰𝘶𝘯𝘥 𝘴𝘵𝘦𝘱 𝘪𝘯 𝘭𝘪𝘧𝘦’𝘴 𝘦𝘷𝘰𝘭𝘶𝘵𝘪𝘰𝘯𝘢𝘳𝘺 𝘩𝘪𝘴𝘵𝘰𝘳𝘺 𝘰𝘯 𝘌𝘢𝘳𝘵𝘩”

09.04.2025 11:44 — 👍 44    🔁 14    💬 1    📌 6

We loved being back on campus for Master's hour on team working! @unibirmingham.bsky.social

The students created content to highlight the excellent research from one of our customers! It's all about the Long Reads 👀 @graingerlab.bsky.social @fozzz21.bsky.social @imibirmingham.bsky.social #MicroSky

05.02.2025 16:52 — 👍 5    🔁 1    💬 0    📌 0

KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid - Nature Microbiology Structural and single-molecule analyses show the CTPase, KorB, is a sliding DNA clamp that interacts with a clamp-locking protein KorA to inhibit gene expression over distances of more than 1 kb in th...

Super excited to share the peer-reviewed version of the KorAB paper. Amazing to work such talented collaborators and thanks to the reviewers for making the work even better!
www.nature.com/articles/s41...

23.01.2025 11:08 — 👍 18    🔁 11    💬 2    📌 1

If you're interested in chromosome biology (DNA folding, gene regulation, replication, polymer modelling and more) we're organising the below this autumn. It'd be great to see you there. Please share if you can. :-)

21.01.2025 19:49 — 👍 27    🔁 29    💬 0    📌 4

Chair Appointments within Manchester Institute of Biotechnology:Manchester Institute of Biotechnology

2x professorships available in Manchester Institute of Biotechnology including in Microbial Engineering area (broadly defined to include microbiomes, environmental biotech etc) — join us!
www.jobs.manchester.ac.uk/Job/JobDetai...

29.11.2024 10:01 — 👍 43    🔁 71    💬 0    📌 1

28.11.2024 12:58 — 👍 32    🔁 9    💬 0    📌 1

grainger birmingham PhD Projects, Programmes & Scholarships FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in grainger birmingham. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.

PhD projects available in our lab all listed in the below link. All focus on bacterial gene regulation, in the context of basic understanding, disease, or antibiotic resistance. Deadlines in January...

www.findaphd.com/phds/?Keywor...

28.11.2024 15:13 — 👍 10    🔁 16    💬 0    📌 0