Iakovos Lazaridis

(first post in this platform) happy to share our new paper on visual-based center-surround interactions in the superior colliculus, showcasing a general approach to dissect local circuit computations. @NeuroAlc

22.10.2025 20:16 — 👍 8    🔁 2    💬 0    📌 0

A horizontally oriented inhibitory neuron (yellow) spans the mediolateral axis of the superficial superior colliculus, with dense axonal arborization suggestive of a role in collicular surround suppression. Retinal ganglion cell terminals expressing ChR2 are shown in cyan (following intraocular AAV injection), while magenta highlights VGAT+ neurons labeled via a reporter AAV-tdTomato in a VGAT-Cre mouse. Image credit Dr. Peng Cui

#Visual #salience generation involves center-surround dynamics, but what performs these computations? This study shows that the #SuperiorColliculus encodes center-surround dynamics under isolated conditions, and provides insights into the circuit implementation @plosbiology.org 🧪 plos.io/4n7RpsA

17.10.2025 13:06 — 👍 3    🔁 2    💬 0    📌 0

Save the date and join us for a webinar about cholinergic interneurons, hosted by the Swedish Basal Ganglia Society. We are excited to have two distinguished speakers: Stephanie Cragg and Mark Howe. Everyone is welcome and no registration is required! swebags.ebrains.se/events/choli...

18.03.2025 14:52 — 👍 4    🔁 1    💬 0    📌 0

Newly characterized striatal circuits add twist to ‘go/no-go’ model of movement control The two novel pathways control dopamine release in opposing ways and may link motivation and mood to action, a new study shows.

The ‘go’ and ‘no-go’ pathways in the basal ganglia are not the only pathways that control movement, as a new study reveals two additional circuits that modulate dopamine and movement.

By @claudia-lopez.bsky.social

#neuroskyence

www.thetransmitter.org/basal-gangli...

24.01.2025 15:04 — 👍 49    🔁 18    💬 2    📌 0

Thank you Christopher, i added the correct link in the comments.

24.12.2024 20:50 — 👍 1    🔁 0    💬 0    📌 0

Striatal Astrocytes Influence Dopamine Dynamics and Behavioral State Transitions We demonstrate here that astrocytes in the striatum interact with striatal dopamine in bidirectional signaling with dopamine release actively driving surges in astrocytic Ca++, which in turn modulate ...

Correct link to the preprint:

www.biorxiv.org/content/10.1...

24.12.2024 20:47 — 👍 0    🔁 0    💬 0    📌 0

Anxa1+ dopamine neuron vulnerability defines prodromal Parkinson's disease bradykinesia and procedural motor learning impairment Progressive degeneration of dopamine neurons (DANs) defines Parkinson's disease (PD). However, the identity and function of the most vulnerable DAN populations in prodromal PD remain undefined. Here, ...

first thing to share here!

excited to share lab’s first study in Parkinson’s disease revealing the prodromal vulnerability and function of the dopamine neuron subtype defined by Anxa1 expression - a specialized system controlling procedural motor learning

www.biorxiv.org/content/10.1...

22.12.2024 22:43 — 👍 32    🔁 7    💬 6    📌 0

Striosomes control dopamine via dual pathways paralleling canonical basal ganglia circuits Lazaridis et al. delineate a previously unrecognized pair of striosomal direct D1 and indirect D2 circuits that target substantia nigra dopamine-containing neurons, controllers of mood, action, and reinforcement learning. These striosomal circuits have effects opposing those of the canonical D1-direct/D2-indirect pathways, likely modulating them.

Check also our recent paper in Current Biology on how striosomes regulate dopamine in the dorsal striatum via dual pathways that parallel canonical basal ganglia circuits.

www.cell.com/current-biol...

mcgovern.mit.edu/2024/10/23/b...

08.12.2024 16:19 — 👍 3    🔁 0    💬 0    📌 0

Interested in dopamine regulation? Don’t forget the astrocytes! We’re excited to share our new preprint on astrocyte-dopamine interactions in the dorsal striatum and behavioral state transitions. @biorxiv_neursci, @mcgovernmit, @AnnMGraybiel

biorxiv.org/content/10.110…

08.12.2024 16:02 — 👍 11    🔁 2    💬 3    📌 0

Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system - Nature Communications Although the heart has its own nervous system, its organization and functionality remain largely unknown. Here, the authors reveal the molecular, chemical, and functional diversity of neurons within t...

Can there be a “little brain” in the heart?
This is one of the “out of the box” project that we performed as KizilLab and
AmpatzisLab. Huge thanks to Andrea, Kostas and Caghan 🤘🏻
#zebrafish #heart #neuron
Check this little brain of the heart:

www.nature.com/articles/s41...

04.12.2024 16:02 — 👍 7    🔁 3    💬 2    📌 0

A Prefrontal Cortex Map based on Single Neuron Activity https://www.biorxiv.org/content/10.1101/2024.11.06.622308v1 The intrinsic organization underlying the central cognitive role of the prefrontal cortex (PFC) is p

A Prefrontal Cortex Map based on Single Neuron Activity https://www.biorxiv.org/content/10.1101/2024.11.06.622308v1

07.11.2024 10:16 — 👍 4    🔁 2    💬 0    📌 0