Warren Bach

In primary school the ink well in my timber desk (circa 1970) often had a sprig of milk weed + monarch caterpillars, or eucalypt + emperor gum moth caterpillars.

🚀 Our new preprint is now live on bioRxiv!
“A systematic benchmark of bioinformatics methods for single-cell and spatial RNA-seq Nanopore long-read data”
🔗 Read here: www.biorxiv.org/content/10.1...

🔬 About the study
We present the first comprehensive benchmark of bioinformatics tools 👇

Long Covid Now Most Common Chronic Health Problem in Children Now that Long Covid has become the most common chronic health condition in children, many more children may require additional support in school.

Now that Long Covid has become the most common chronic health condition in children, many more children may require additional support in school. pizer.law/long-covid-n...

Congrats Hasindu and Nanopore Garvan team. This is an exciting development. I remember asking myself how AS might be used when it was first released. You have truely answered this 🙌🎉

YouTube video by David Eccles Sequencing That Stimulates The Sensors - TEDx Presenter's Cut

Because I recently stealth-shared this with the nanopore sequencing community, I figured I might as well post this here as well. This is a TEDx talk I gave in 2016, which I believe is the first public on-stage demonstration of nanopore sequencing:

www.youtube.com/watch?v=kQK3...

Fantastic and well deserved. Build a useful too and let innovators run wild 😎

🌟 Client Publication Highlight! 🌟 We're proud to share a little summary of a recent study by Furnell et al (2024) who used the Ramaciotti Centre's long read (ONT) sequencing and Sanger sequencing services🧬

This week, we established a new Grant Programme to support researchers who are pursuing breakthrough science but may lack all the resources to access Oxford #Nanopore sequencing.

Find out more and how you can apply here: register.nanoporetech.com/grants-progr...

#AnythingAnyoneAnywhere

Well I wasn’t expecting that! Another amazing application with @nanoporetech.com
I might have to review my personal use of the overused term “Multiomics” 😉

Telomere-to-telomere DNA replication timing profiling using single-molecule sequencing with Nanotiming - Nature Communications Current temporal studies of DNA replication are either complex or low-resolution. Here, the authors introduce Nanotiming, a simple and inexpensive method producing high-resolution, telomere-to-telomer...

NanoTiming is now in Nature Communications! High-resolution DNA replication timing using nanopore sequencing shows that Rif1 regulates only specific telomeres: www.nature.com/articles/s41...

Investigating the performance of Oxford Nanopore long-read sequencing with respect to Illumina microarrays and short-read sequencing https://www.biorxiv.org/content/10.1101/2024.12.19.629409v1

Researchers using Oxford Nanopore Tech. long-read sequencing effectively identify pathogenic structural variants in the PRKN locus that were missed by conventional methods; They propose that it should be considered for unresolved early onset #Parkinsons cases
onlinelibrary.wiley.com/doi/10.1002/...

Evaluating data requirements for high-quality haplotype-resolved genomes for creating robust pangenome references - Genome Biology Background Long-read technologies from Pacific Biosciences (PacBio) and Oxford Nanopore Technologies (ONT) have transformed genomics research by providing diverse data types like HiFi, Duplex, and ult...

Our hitchhiking paper is out at genomebiology.biomedcentral.com/articles/10.... great collaborative effort with Prasad Sarashetti, @jlipovac.bsky.social, Filip Tomas and JJ Liu.
Briefly, the nanopore is enough for high-quality human genomes. Recently, HERRO showed that even UL is sufficient. 1/3

Release v0.9.0 · nanoporetech/dorado [0.9.0] (16 Dec 2024) This major release of Dorado introduces several new features and enhancements. The polish command, currently experimental, is optimised for refining draft assemblies of human ...

🎄 New Dorado release (v0.9.0) – and it's big!

🚀 Dorado polish command (experimental) for improving draft assemblies – faster & more accurate than Medaka
⚡ Faster modified base calling models
🔧 Usability & accuracy improvements: PolyA, Barcoding, 6mA calling

github.com/nanoporetech...

𝗖𝗲𝗹𝗲𝗯𝗿𝗮𝘁𝗶𝗻𝗴 𝗢𝗻𝗲 𝗬𝗲𝗮𝗿 𝗼𝗳 𝗜𝗺𝗽𝗮𝗰𝘁𝗳𝘂𝗹 𝗜𝗻𝗱𝗶𝗴𝗲𝗻𝗼𝘂𝘀 𝗚𝗲𝗻𝗼𝗺𝗶𝗰𝘀 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗮𝘁 𝗔𝗡𝗨 𝗡𝗖𝗜𝗚 - 𝗧𝘄𝗼 𝗟𝗮𝗻𝗱𝗺𝗮𝗿𝗸 𝗣𝘂𝗯𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 𝗶𝗻 𝙉𝙖𝙩𝙪𝙧𝙚 with nearly 50,000 accesses and rankings above the 98th percentile globally. Thank you to our collaborators and Indigenous communities for your trust. Details on ANU NCIG LinkedIn Page.

2024 Top 10 Innovations The latest group of winning technologies has a little something for everyone—from scientists at the lab bench to those in the clinic and even the classroom.

It’s incredibly gratifying to see our work on Direct RNA sequencing getting recognised in this way. Congratulations to all the team at @oxfordnanopore.bsky.social who helped us to make it a reality!

www.the-scientist.com/2024-top-10-...

#RNASequencing #Innovation #NanoporeSequencing #RNAResearch

We got there in the end 😁
Thanks for sticking with us 👍

Publication exploring the future potential of nanopore sequencing for clinical use.

What you're missing matters. #WYMM #SwitchON

Fantastic @rhystwhite.bsky.social
Any @nanoporetech.com users I haven’t met, give me a 👋

Guess where I have been this week ?
(Yes they are cheese scones)

We are proud to announce a collaboration with UK Biobank to create the world’s first large-scale #epigenetic dataset of 50k participants. The dataset will unlock crucial insights into how #epigenetics drives disease & the breakthroughs to treat them.

Read more: nanoporetech.com/news/oxford-...

Great, I was starting to feel a little lonely 😁

Please register for the course on Transposable elements in #genomics and #datascience. We will be sharing the magic of #nanopore long reads for #transposon expression #tesky

My stats have taken a hit as I was closing in on 1000 followers and following, and I am pretty selective 😉
Looking forward to a more wholesome environment.