Kaiyuan Sun

We're organizing a special session called "The Art of Epidemics" at #Epidemics10! The session focuses on how thoughtfully designed visualizations and communication tools can make complex epidemiological data more impactful. artofepidemics.wixsite.com/epidemics10

Epidemiology models explain rumour spreading during France’s Great Fear of 1789 - Nature Epidemiological methods are used to show that the Great Fear of 1789, a series of peasant insurrections in rural revolutionary France, was driven by deliberate political action rather than spontaneous...

Very interesting study on social contagion applied in a historical context by @szapperi.bsky.social and collaborators. Powerful example of where good historical data can lead us in the future.

www.nature.com/articles/s41...

Rare postdoc opportunity to study the emergence and evolution of pandemic viruses in the lab of Dr. Martha Nelson in the Division of Intramural Research (DIR) at the National Library of Medicine (NLM).

www.training.nih.gov/jobs/pdf-cb-...

Would love to be added to the list, thanks in advance.

A single shot of a flu drug could outperform vaccines—and protect for an entire season One injection of a long-lasting drug showed up to 76% efficacy in a large trial

“This is one of the most exciting recent advances for influenza prevention." www.science.org/content/arti...

Sang Woo (Daniel) Park and I are excited to share a new preprint, "Susceptible host dynamics explain pathogen resilience to perturbations" [1/8]

www.biorxiv.org/content/10.1...

Fine-scale patterns of SARS-CoV-2 spread from identical pathogen sequences - Nature The analysis of pairs of identical SARS-CoV-2 genome sequences enables characterization of transmission patterns between geographies and age groups.

Pathogen genomes can provide insights into underlying disease transmission patterns but new methods are needed to analyze large genome datasets. Our work using identical pathogen sequences to characterize fine scale SARS-CoV-2 transmission was just published in @nature.com tinyurl.com/bdzk9xjj 🥳

Pandemic monitoring with global aircraft-based wastewater surveillance networks - Nature Medicine By simulating the implementation of airport-based wastewater surveillance sites at the global level, a modeling study shows how this early warning system would perform in identifying sources of pandem...

Wastewater from airplane toilets?
We introduce a global Aircraft-Based Wastewater Surveillance Network (WWSN) for pandemic monitoring in Nature Medicine 🔗 doi.org/10.1038/s415...

Aircraft-based wastewater surveillance allows for real-time, non-invasive monitoring of global pathogen spread
Short 🧵

Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans - Nature Microbiology The authors demonstrate the effectiveness of T cells in controlling acute viral infections, without neutralizing antibodies, by conducting an Orthoflavivirus vaccination and challenge study in humans.

Two new reports on T cells and viral infections
—the ability to prevent without neutralizing antibodies
www.nature.com/articles/s41...
—more Tregs and enhanced protection via multiple Covid booster shots
www.biorxiv.org/content/10.1...

Tour de force talk by Cheryl Cohen (head of NICD & Prof at Witwatersrand) on detailed household epidemiology of respiratory viruses in South Africa in the PHIRST study.
The depth of insight coming from these kind of long-running, thorough epi studies is impressive!
She thanked participants first! 👏

Excited to have Cheryl Cohen from NICD giving a CEPR seminar Wed 27th Nov at 12.50pm (online and in person). If you’re interested in respiratory infections, you won’t want to miss this - a great project with some fascinating findings:

www.lshtm.ac.uk/newsevents/e...

I’ve updated SARSCoV2 RBD antibody-escape calculator w new deep mutational scanning data of Yunlong Cao & Fanchong Jian.

My interpretation: antigenic evolution currently constrained by pleiotropic effects of mutations on RBD-ACE2 affinity, RBD up-down position & antibody neutralization

The preliminary sequence from the H5N1 human case in British Columbia has been posted and it is not good news. The virus potentially has a quasispecies at HA residue 226 (H3 numbering). This is bad news because we know that mutations at residue 226 can increase binding to human receptors. 1/