Ryan Hisner

Hahahaha

YouTube video by ryhisner Elephant Micah - "Blue Ridge"

Had me at "Rural District Lo-Fi Recording Project." Reminds me of the Luddite Rural Recording Cooperative that Elephant Micah released his early records on—all among my all-time favorites, esp. Loud Guitars, Palmyra Palm, Agrarian Malaise, & Hindu Windmills. www.youtube.com/watch?v=0Zc5...

60 new sequences from Germany 🇩🇪, 40% are BA3.2*. Update for December 1-21, 2025:

BA.3.2 has gone from ~8% to ~44% of all sequences in Scotland over the course of December.

Larger sample sizes in a smaller nation (Scotland), unsurprisingly present a much more consistent picture in variant trends than smaller sample sizes over a much larger, more heterogeneous country (Germany).

Point blank.
10-shots.
Execution.
A US citizen, a VA ICU Nurse.
Then lying.
Blocking a real investigation.

While transmission is unlikely it can't be ruled out. At least 2 Cryptic-like variants have transmitted:

• Early 2022, Iran, 4 patients, ≥1 death (a child)
• From Canary Islands (Dec 2022/Jan 2023) to Spain (Oct 2024), 2 patients, ≥1 death.

bsky.app/profile/ryan...

New Cryptic (North Carolina) derived from a 2020, pre-B.1.1 lineage, meaning from an infection that has lasted nearly six years.

It has one of the classic patterns of Cryptic reversions to Bat-CoV/SARS-1 spike residues: Q498Y-N501T.

Eager to see the rest of the genome.

What do the 23007 and 23099 signify?

New @dropsitenews.com video from opposite side confirms: man in gray coat & red-billed cap disarmed the victim—who was legally carrying & never reached for or touched his gun—before any shots were fired.

See his mittened, empty hands reaching to the victim's waistband, then emerging with the gun.

Do you have any familiarity with government surveillance and infiltration of protest movements? The employment of agents provocateurs here is a near certainty—unless you think the Trump admin is uniquely high-minded and principled in this regard.

There are no doubt government agents provocateurs posing as protestors trying to provoke violence.

Not saying this is the case with everyone, but this needs to be kept front of mind when we see calls from alleged anti-ICE people & accounts pushing for violence.

Really excited our paper about how H5N1 rapidly adapted to cattle (and how these adaptations also increased its ability to infect cells from the human respiratory tract) is now published! www.nature.com/articles/s41...

I'll say it again: Minneapolis will be their Gettysburg

in case you're curious about how angry Minnesota is about ICE, it was -20 today

Hell yes. Thank you for doing what you're doing.

Can you imagine how Kepler would have reacted had he known about the geometry of viral capsids? Pretty sure he would've written books about it and expanded it into a theory of all life.

Debt forgiveness for normal people—erasing health care debt or student-loan debt—is unthinkable to Republicans & their many Dem collaborators like C Booker, Buttigieg, etc—but canceling debt for corporations & the rich thru bankruptcy or fraud is par for the course.

Jubilee for me but not for thee.

E. Bruised ego, severe case of snowflake/fragile butterfly syndrome

Several of the A->G muts here have been seen in previous A->G clusters.

And as always, the entire A->G cluster happens all at once—never stepwise.

Phylogenetic tree courtesy of the @angieshinrichs.bsky.social-curated SARS-CoV-2 Usher tree. 2/2

One new A->G cluster showed up today in an XFG from Brazil. 10/13 private nuc mutations here are A->G, and eight of them appear in a 229-nt stretch in the spike NTD.

Still no idea what's behind these, though some sort of unusual ADAR fusillade seems to be the best guess. 1/2

Seems to be the most dramatic breakthrough in preventing/slowing dementia & alzheimer's ever. But it's a vaccine, so it doesn't get headlines.

Wish you could get the shingles vaccine before age 50. You don't have to be 50 to get shingles—I can attest as I had it last summer (not recommended).

They are targeting children because they are trying incite violence. I have talked to many journalists today, and they all made the same observation: Border Patrol and ICE have been rolling around with maximum aggression, lingering for ages as crowds, gather, seemingly trying to cause a riot.

The Trump administration's brutality is on graphic display in Minneapolis and its vulgar stupidity in the Greenland fiasco, but just as harmful, though less splashy, is the way they are destroying US science.

Yes, this was a memorable post of his on mRNA vaccines and how their use is tantamount to eugenics.

Yes, alongside some other bold claims.

There's also a weird online Novavax cult that seriously distorts the evidence to claim that Novavax is vastly superior to mRNA. Not sure if this is primarily an anti-mRNA thing or what.

And ∆141-143 is definitely deleterious. The phylogenetic evidence for this was already very strong, and two separate studies have confirmed that ∆141-143 reduces viral fitness and NSP1's ability to shut down host translation. 3/3
bsky.app/profile/ryan...

I suspect these are compensatory mutations for the ∆84-86 and/or ∆141-143 NSP1 deletions.

At least one study that found NSP1 deletions from 82-86 to be deleterious, & the lack of 82-86 deletions in nearly all major lineages (despite countless independent acquisitions of them) supports this. 2/3

Still more new NSP1 mutations in the BA.3.2 uploaded from the Netherlands today. We've never seen anything like this kind of rapid evolution in NSP1 (whose primary role is to shut down host-protein translation and degrade host mRNA).

I've labeled all BA.3.2-specific NSP1 muts here. 1/3

It appears to have regained ORF7-8, but with no other signs of recombination, I think there's a very high likelihood this is due to contamination. Need to wait to see if the lab can confirm/refute this looking at the raw reads.