Really happy to see this out! It was a wonderful collaboration.
25.02.2026 09:30 — 👍 1 🔁 0 💬 0 📌 0
Open questions we’re excited about:
• Which neuronal proteins are UFM1 targets?
• How do disease variants alter the neuronal translatome?
• Could modulating ER stress or translation be therapeutic?
Happy to discuss or hear ideas
25.02.2026 09:25 — 👍 0 🔁 0 💬 0 📌 0
Main finding:
Disrupting UFM1 causes defects in neuronal maturation and function:
neurons become smaller, less morphologically complex, and show reduced synaptic signaling. In parallel, we observe increased ER stress and UPR activation together with decreased protein synthesis.
25.02.2026 09:25 — 👍 0 🔁 0 💬 0 📌 0
What is UFM1?
UFM1 is a ubiquitin-like protein (UBL). Like ubiquitin, it modifies other proteins through conjugation, but its function in neurons is unknown.
Patients carrying UFM1 mutations develop severe neurodevelopmental disorders, so we wanted to understand what goes wrong at the cell level.
25.02.2026 09:24 — 👍 0 🔁 0 💬 0 📌 0
Leibniz Institute: Hans Knöll Institute
Jena
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