Yogesh Kulathu

Biological Laboratory | LEGO® Ideas This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗
beta.ideas.lego.com/product-idea...

Wow! really cool story Kathrin. Congrats to you and your team

Systematic Discovery of Motif-based Interactions of the Auxiliary Domains of USP Family Deubiquitinases The ubiquitin-specific proteases (USPs) family is the largest family of human deubiquitinating enzymes (DUBs). While most USPs are agnostic to polyubiquitin linkage-type, their substrate specificity i...

Finally out! Thrilled to share our collaboration with @kulathu.bsky.social, @orafurman.bsky.social, and N Davey. We screened auxiliary domains of USP family #deubiquitinases, revealing short linear motifs (SLiMs), contributing to specificity in complex assembly.
www.biorxiv.org/content/10.1...

A few months ago, our review “The Molecular Toolbox for Linkage Type-Specific Analysis of Ubiquitin Signaling” 🧬🧰🛠️ came out in ChemBioChem. Time to give it a spotlight!

chemistry-europe.onlinelibrary.wiley.com/doi/full/10....

The annual meeting highlights how the Lister is so unique - such a wonderful community of kind, committed people. Stellar scientists, of course. But also deeply passionate about nurturing teams, opening doors, and enabling others to develop skills and meaningful careers. Thank you.

Congrats Leo!

UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains Ubiquitin chains determine the fates of their modified proteins, including proteasomal degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation and deubiquitination at hi...

Super excited to share our latest work on deciphering the #Ubiquitin Code

“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”

@cp-molcell.bsky.social

1/8

www.cell.com/molecular-ce...

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.

rdcu.be/edRwF

Joint 2025 Autophagy UK and Proteostasis UK conference

Registration for the second UK Proteostasis Network meeting in Dundee is open!
The conference will run from Tuesday 3 June 2025 - Thursday 5 June 2025 and is joint with Autophagy UK. Please follow the link below to sign up: dundee.ac.uk/events/joint...

Such a fun collaboration with @michaelnadbio.bsky.social! Check out the latest form of #ubiquitin modification- MARUbylation!

Joint 2025 Autophagy UK and Proteostasis UK conference | University of Dundee, UK Welcome to the 2025 joint “Autophagy UK and Proteostasis UK” conference!

Autophagy UK & Proteostasis UK joint meeting -June 3-5. Exploring the lifecycle of cellular components from synthesis to degradation. Going to be a great meeting and we look forward to welcoming you to Dundee! Exciting lineup of speakers and opportunities for ECRs
Register here: tinyurl.com/mr3p49f9

Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells. | PNAS A polypeptide of 8500 molecular weight is described that induces the differentiation of T (thymus-derived) cell and B (bone-marrow-derived) cell im...

By my reckoning, yesterday marked the 50th anniversary of ubiquitin's discovery! 🎈🎉🎁🥂
www.pnas.org/doi/10.1073/...

Congrats Ana on the first paper feom your lab 🎉🎉

A functional screen for ubiquitin regulation identifies an E3 ligase secreted by Pseudomonas aeruginosa Ubiquitin signaling controls many aspects of eukaryotic biology, including targeted protein degradation and immune defense. Remarkably, invading bacterial pathogens have adapted secreted effector prot...

Excited to share this work from former Pruneda Lab superstar Cameron Roberts! Cam tackled the challenge of identifying #ubiquitin regulators secreted by pathogenic bacteria, and found an entirely new type of E3 ligase that regulates P. aeruginosa virulence!

www.biorxiv.org/content/10.1...

Could't think of a better inaugural post here. Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology. Congratulations Kim, Kai, and all authors! www.nature.com/articles/s41...

Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12 The oxidative stress response is centered on the transcription factor NRF2 and protects cells from reactive oxygen species (ROS). While ROS inhibit the E3 ligase CUL3-KEAP1 to stabilize NRF2 and elici...

Excited to report our discovery of an important component of the oxidative stress response: the E3 ligase TRIP12. It acts as a chain elongation factor that amplifies CUL3-KEAP1 activity to drive NRF2 degradation as cells recover from stress.

www.biorxiv.org/content/10.1...

I want to write a paper titled “the sky is blue, the ocean is deep and trees are green”

Finally out! A huge update from the preprint is a beautiful structure by James Chen of Pup-Dop-CoaX, the first known regulator of depupylation! www.pnas.org/doi/10.1073/...

Congrats Heran! Very cool story

The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo The acute skin reaction to sunburn, encompassing keratinocyte cell death, inflammation, and epidermal thickening, has traditionally been ascribed to DNA damage responses. Using a mouse model deficient...

Time for our first post here 🥳 Our latest paper is online 🙌
We show that UV activates the ribotoxic stress response, which causes inflammation, cell death and thickening in skin. Read about a role for the RSR separate from DNA damage signaling in response to sunburn: ✨☀️ www.cell.com/molecular-ce...

Yup! I hate the word resilience. I dream of a world where Black and Brown ppl never have to be resilient and get to be. Joyfully lovingly be.

Bluesky is emerging as the new platform for science - Mike Young Academy Scientific Twitter is about to find its true successor. And it is not X. This, our latest release, shows that the Bluesky network of scientists is growing — and growing.

A mapping of how Bluesky is becoming the new Scientific Twitter

mikeyoungacademy.dk/bluesky-is-e...

Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn

Really proud of this paper just out in JCB. At almost every turn, SURF4 surprised us. Amazing PhD student, Julija Maldutyte, sleuthed it out.
rupress.org/jcb/article/...

Structure of the TXNL1-bound proteasome Proteasomes degrade diverse proteins in different cellular contexts through incompletely defined regulatory mechanisms. Here, we report the cryo-EM structure of thioredoxin-like protein 1 (TXNL1) boun...

So many things happen on proteasomes! It was fun to dig into how a the active thioreductase TXNL1 engages the regulatory particle!

www.biorxiv.org/content/10.1...