Miranda So PharmD MPH (Epidemiology)

The Case for Case–Cohort: An Applied Epidemiologist’s Guide ... : Epidemiology recision for addressing a singular research question, but case–cohort studies have broader efficiency and superior flexibility. Despite this, case–cohort designs are comparatively underutilized in the...

Went down a small rabbit hole to refresh my understanding of case-cohort design for a project. Here is a nice review in the journal #Epidemiology, comparing case-cohort to nested case-control, which is more common.

#ResearchMethods fascinates me!

journals.lww.com/epidem/abstr...

Fewer than 10% of published observational studies in this sample used DAGs to justify confounder selection.

This is a huge missed opportunity for both readers and researchers.

DAGs are invaluable in research design and critical appraisal.

Hazy sunset due to #wildfires
🏃🏻‍♀️

Oral Vancomycin for Prevention of Recurrent Clostridioides difficile Infection This randomized clinical trial examines whether prophylactic oral vancomycin vs placebo reduces recurrent Clostridioides difficile infection in adults receiving antibiotics for another indication.

Interesting study in @jamanetworkopen.com on vancomycin PO to prevent recurrent C. difficile infection. Speaks to the challenges of study design to evaluate effects of prophylaxis. I commend the authors for their efforts.

jamanetwork.com/journals/jam...

Confounder Selection in Observational Studies in High-Impact Journals This cross-sectional study investigates whether there have been improvements over time in the methods reported for selecting confounders in observational studies published in the highest impact factor...

Enjoyed reading this review from @jamanetworkopen.com !
I have been providing an educational series for team members about reseach methods. We had lots of discussions about how to manage confounding in observational studies.
jamanetwork.com/journals/jam...

📌

Incidence and risk factors for musculoskeletal adverse effects associated with daptomycin in patients receiving outpatient parenteral antimicrobial therapy | Antimicrobial Stewardship & Healthcare Epidemiology | Cambridge Core Incidence and risk factors for musculoskeletal adverse effects associated with daptomycin in patients receiving outpatient parenteral antimicrobial therapy - Volume 5 Issue 1

@bryanpwhite.bsky.social et al: In a cohort (n=127) of OPAT patients on daptomycin 7.4 mg/kg for an average of 37 days, the rate of CK elevation was 11.8% at a median of 13 days (IQR 9-16) supporting weekly lab monitoring on daptomycin for OPAT. doi.org/10.1017/ash....

📌

I spent my childhood in and out of hospital. At 19, I finally realised I had a terminal disease Born with cystic fibrosis, Yvonne Hughes was lucky to survive her teens. She definitely didn’t expect to make it into her 50s. The comedian talks about the years she spent struggling to breathe – and ...

A patient’s lived experience with #cysticfibrosis

www.theguardian.com/lifeandstyle...

Great review on #antimicrobialstewardship strategies related to new agents and PK/PD modelling.

www.mdpi.com/2079-6382/14...

📌

📌

Always appreciate how lovely the Toronto summer is. 🇨🇦

S02 Episode 3: The Guidelines Podcast Episode · The Retrievals · S2 E3 · Subscribers Only · 55m

This series from @nytimes.com is so educational (and frankly, frightening) for healthcare professionals. We need to listen to patients. #PatientEngagement #PatientSafety

podcasts.apple.com/ca/podcast/t...

📌

📌

Public hearings - UK Covid-19 Inquiry The independent public inquiry to examine the Covid-19 pandemic in the UK

The UK COVID-19 inquiry continues to be +++educational for me. The struggle with making wide-ranging governmental policies based on ever-changing evidence, which led to rapidly evolving and sometimes conflicting recommendations is palpable.
I can empathize.
covid19.public-inquiry.uk/public-heari...

📌 Congratulations! Wish I saw it yesterday while preparing for transplant fellows orientation slides! Will be talking about it this morning. 👏👏👏

📌

Second time I've baked bread ever. Decided to try this super simple vegan recipe on Canada Day! Baking bread feels like a chemistry experiment....
lovingitvegan.com/easy-no-fail...

Got a 10km Canada Day run in this morning. A bit hot and sticky but just the way I like it! 🏃🏻‍♀️ lots of fellow runners, walkers and cyclists.

FIRST PERSON | When the day came that my son no longer needed a heart monitor, everyone was happy but me | CBC News Natasha Chiam struggled to let go of the reassurance from the monitor that all was good with her child, when just a week earlier, his little seven-year-old heart had stopped. More than 10 years later,...

Wow. What a story.

#sepsis

www.cbc.ca/news/canada/...

An interesting notion: balancing the need to jumpstart sepsis management vs. #antimicrobialstewardship. To me, rather than characterizing it as a "tension", I would reframe it - we are on the same side to optimize care, for which we need SYSTEM-LEVEL interventions.
www.thelancet.com/journals/lan...

Antibiotic stewardship in the ICU: time to shift into overdrive - Annals of Intensive Care Antibiotic resistance is a major health problem and will be probably one of the leading causes of deaths in the coming years. One of the most effective ways to fight against resistance is to decrease ...

Hugely insightful review of #Antimicrobialstewardship in the ICU. Excellent analysis of the concept of de-escalation - be more mindful re: what antibiotics we are de-escalating with, especially the impact of anti-anaerobic options.

annalsofintensivecare.springeropen.com/articles/10....

Antimicrobials in serious illness and end-of-life care: lifting the veil of silence Global rates of antimicrobial consumption increased by 65% between 2000 and 2015, by 16% between 2016 and 2023, and are estimated to increase by an additional 52% by 2030. Antimicrobial use and misuse...

Excellent review on the importance of #antimicrobialstewardship at the end of life in from a global perspective in @thelancetinfdis.bsky.social
Useful framework for clinicians suggested.
www.thelancet.com/journals/lan...

Midwives & Mothers: A History of Birth in Ireland Podcast Episode · Irish History Podcast · 2025-05-28 · 29m

Excellent episode! Thank science for how far we have come in maternal-newborn health and infant mortality!

Sanitation
Obstetric care
Neonatal care
Screening
Antibiotics
Vaccines

#PublicHealthSky #MedSky

podcasts.apple.com/ca/podcast/i...

📌

Caregiver Toolkit Make a difference in the field of transplantation by donating to support our cause.

The Caregiver Toolkit is a valuable resource for patients and their loved ones navigating the transplant journey.

💡 A great resource to share with your patients and their families!
🔗

📌

📌