Paweł Pasikowski

Most certainly yes, still have one of those ;)

The entities enabling scientific fraud at scale are large, resilient, and growing rapidly | PNAS Science is characterized by collaboration and cooperation, but also by uncertainty, competition, and inequality. While there has always been some c...

🧪🌾 Fascinating and discouraging report on the growth of false science reports: www.pnas.org/doi/abs/10.1...

On the second chromatogram You just get electronic noise. I would first check, if the ion source voltage is ok (acquisition method can change to default value after the machine restarts). Also check if the voltages in software diagnostics are all ok. It is possible that Your HV supply to died

This also wastes humanity's resources, btw. The fact that there is no publication of stuff that doesn't work means that a bunch of people can independently try the same failing approach without ever knowing what was done before them, or having any way to know. Over and over again.

Yeah, knowing that guy it is probably a good move for wrong reasons ;)

Cheese Weather How does climate change affect cheese quality? This poem and explainer explore drought, feed, and flavour in traditional dairy farming.

🧪 Science Poem 🖋️

New research has found that climate change and cheese quality are closely linked – with drought reducing grass, altering milk, & muting flavour.

Here's my poetic interpretation: scienceblog.com/thepoetryofs...

#SciComm 🍎 🐄 #Poetry #ClimateChange #Cheese

Comic. [block quote] “Far better an approximate answer to the *right* question, which is often vague, than an *exact* answer to the wrong question, which can always be made precise.” -John W. Tukey, The Future of Data Analysis (1962) [caption] Happy Approximate Birthday to John Tukey, author of my favorite statistics quote, who was born 110.000 years ago sometime this week.

Tukey

xkcd.com/3104/

Fortunately, there are many software options to process .RAW files without even touching PD ;)

Carl Sagan in 1986 on the problems with media and science literacy.

I've learned a lot about MS during my PhD (2007-11) and did some peptide/protein analysis back then. This gave me quite nice background to learn real proteomics later on during my work in MS core facility.

Still, this additional analyzer enhances some capabilities (particularly if one have a fetish for reaaaaaly high resolution).

BTW, You used "Orbitrap" and "discount" in one sentence. This made me giggle ;)

Yeah, just remember that specs for these two are not identical. This $1M difference may have something to do with the small thing called the Orbitrap, that they put inside the Astral. Is it worth $1M? This is a completly different question.

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n

Haha, just a minute after I've posted this reply, this fun profile followed me: bsky.app/profile/reti... ... AI overlords You say? ;)

Sounds great. I think I could enjoy early retirement...

So uhh…sorry for the nightmare fuel, but I wrote about how microplastics seem to be messing with photosynthesis. 🌏🧪

YouTube video by Times Radio Why Elon Musk's plans to colonise Mars are bound to fail

Me and Kelly in video form: www.youtube.com/watch?v=oN_C...

Dear #ProtemicSky community, I seek help! Anyone here working (preferably for a long time or extensively) on Exploris 480? I experience a peculiar problem on my machine and would appreciate any help (BTW, yeah, Thermo guys do not know what it is... at least yet)

Oh, sorry, wasn't aware of this. Thanks for correcting me ;)

ProAlanase is an Effective Alternative to Trypsin for Proteomics Applications and Disulfide Bond Mapping The ProAlanase protease cleaves after proline and alanine residues in highly acidic conditions and provides efficient digestion of proline-rich proteins allowing for accurate phosphorylation site prof...

You can always try ProAlanase. I think it is patented by Promega. I personally used it for some Lys-rich proteins (should work well for histones) but not for global proteomics, as it is a bit expensive. Here is a nice paper from Olsen lab though: www.mcponline.org/article/S153...

Rly? This is pretty rare to see people appreciating all of the 90s grunge and not knowing Tool. This is Ænima, Tool's 2nd LP and imho a masterpiece. Oh man, I envy You a bit that You don't know it, cause You are in for a treat.

Ok, one more but I promise this is the last one ;)

This, of course: