Mathias V. Schmidt

Check out the full study here: doi.org/10.64898/202...
Kudos to the fantastic team, especially lead author Sowmya Narayan and our incredible collaborators.

By combining advanced behavioral phenotyping with whole-brain c-Fos mapping, manganese-enhanced MRI, and transcriptomics in mouse models, we found that developmental stress often has opposite neurobiological effects in males vs. females.

I’m thrilled to share our latest preprint from the lab, now available on BioRxiv! We investigated how early life adversity (ELA) shapes the adult brain, and the results are a stark reminder that sex isn't just a variable but leads to fundamentally different stress-induced mechanistic consequences

This is the path to robust, translational data. 𝐃𝐨𝐧'𝐭 𝐏𝐚𝐧𝐢𝐜! Read the full guide and join the shift to deep phenotyping.
Thanks to all co-authors and the incredible teamwork including @benjurek.bsky.social, Patrick Schlegel, @london-k-aman.bsky.social, Bartosz Zglinicki and @mikeyslezak.bsky.social

We provide:

- A standardized workflow for long-term home-cage monitoring in mice.
- A practical guidance on experimental setups for 24-hour recordings.
- A comparison of contrast- vs. ML-based tracking tools, with pros, cons, and use-cases
.. and much more!

Long-term deep phenotyping of behavioral traits in mice using homecage monitoring Neuropsychiatric disorders represent a significant global health challenge, and a deeper understanding of their underlying neurobiology is urgently ne…

Check out our new paper in Neuroscience & Biobehavioral Reviews: "𝑳𝒐𝒏𝒈-𝒕𝒆𝒓𝒎 𝒅𝒆𝒆𝒑 𝒑𝒉𝒆𝒏𝒐𝒕𝒚𝒑𝒊𝒏𝒈 𝒐𝒇 𝒃𝒆𝒉𝒂𝒗𝒊𝒐𝒓𝒂𝒍 𝒕𝒓𝒂𝒊𝒕𝒔 𝒊𝒏 𝒎𝒊𝒄𝒆 𝒖𝒔𝒊𝒏𝒈 𝒉𝒐𝒎𝒆𝒄𝒂𝒈𝒆 𝒎𝒐𝒏𝒊𝒕𝒐𝒓𝒊𝒏𝒈"
This paper is your essential 𝐇𝐢𝐭𝐜𝐡𝐡𝐢𝐤𝐞𝐫'𝐬 𝐆𝐮𝐢𝐝𝐞 to achieving unprecedented insight into complex rodent behavior. www.sciencedirect.com/science/arti...

To truly understand the neurobiological basis of complex behaviors - the real 𝐦𝐞𝐚𝐧𝐢𝐧𝐠 𝐨𝐟 𝐥𝐢𝐟𝐞, 𝐭𝐡𝐞 𝐮𝐧𝐢𝐯𝐞𝐫𝐬𝐞, 𝐚𝐧𝐝 𝐞𝐯𝐞𝐫𝐲𝐭𝐡𝐢𝐧𝐠 - we must overcome the limitations of traditional, short-term behavioral tests.

Interesting talk by @kgoepfrich.bsky.social on RNA design and synthetic cells.

🚨Open position at #FENS!

💭Do you want to help strengthen the voice of #neuroscience?
Apply for the Advocacy and Engagement Internship at FENS!

🗓️ The deadline for applications is 31 October!
👉 https://loom.ly/2Qy18y8

Looking forward to this exciting conference. If you are interested in the latest science on the developmental origins of mental illness, join me and my co-chair @talliezee.bsky.social for our session on Sunday morning at 11:20am.

Very happy to share our new paper in Biological Psychiatry, showing that Urolithin A reverses high anxiety by repairing mitochondrial function in the nucleus accumbens.

Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators!

🔗 Paper: doi.org/10.1016/j.bi...

Astrocytic glutamate regulation is shaped by adversity and glucocorticoid signalling Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear. Here, we probed the di...

Latest lab preprint! Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear... so we dived in:

www.biorxiv.org/content/10.1...

Important initiative 👇

Ready for some really hot 🔥🥵 data on stress and trauma effects across the life span, join us at the 17:30 symposium @ebbsociety.bsky.social with @biancasilvalab.bsky.social.

The heat won’t stop the energy — science (and fans!) in full swing!
🔆🪭💪
#EBBS2025

In Bordeaux for the #EBBS meeting. Looking forward to 4 exciting days of science

Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides Steroid hormones and neurosteroids (collectively neuroactive steroids), alongside neuropeptides, are key modulators of the central nervous system. The…

🚨 NEW PAPER 🚨
Thrilled to share our latest work in "The Neurobiology of Stress" where we highlight the intricate roles of neuropeptides and neurosteroids in psychiatric disorders, & how new technologies can answer old questions about these important signallers. sciencedirect.com/science/arti...

The Be Open about Animal Research Day is starting now!
Show your support and share on #BOARD25

Events — Neurobiology of Grief International Network

🎉It's happening - The Neurobiology of Grief International Network (NOGIN) comes to Europe! We are happy to host NOGIN from Sept 17-19 in Regensburg/DE. Registration is already open, seats are strictly limited to 100 participants. More information here:
www.neurobiologyofgrief.org/events

The evolving neurobiology of early-life stress This review explores the effects of early-life stress on brain development and cognitive function, highlighting gaps in understanding perceived stress, vulnerable developmental stages, underlying mole...

Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...

Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry Autoimmune diseases are a heterogeneous category of disorders caused by an interaction between genetic and environmental factors which lead to a dysre…

Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry www.sciencedirect.com/science/arti...

Early Life Stress Can Build Resilience in Females Stress in early life can improve emotional regulation and cognitive function in female mice. This is a significant departure from the traditional view that such stress is solely detrimental. The study...

Read about our recent discoveries on mechanisms that can drive resilience in females.
www.psych.mpg.de/2949097/news...

So well deserved! Congratulations 👏🏻👏🏻👏🏻

The Peter Seeburg Integrative Neuroscience Prize honors groundbreaking work that bridges molecular & systems neuroscience to advance our understanding of cognition, emotion, memory, & decision-making. 🔬 Celebrate bold science. Nominate now.
#Neuroscience #BrainResearch

www.sfn.org/careers/awar...

Intergenerational Effects of Stress – A Focus on Learning and Memory Stress is a ubiquitous facet of life. Ranging in form (e.g., psychosocial, physical, nutritional, economic) and longevity (e.g., acute, chronic), stressors affect the biology of those directly in thei...

Intergenerational Effects of Stress - A Focus on Learning and Memory
doi.org/10.1007/7854...

lab but aesthetic 🤩 comment how a typical day looks for you #sza #dayinlife #interviews #science #lablife #labtech #behindthescene TikTok video by trainor lab

We're using a lab TikTok account to try and get the message out about why science is important. The latest post from @neurani.bsky.social and @g-lia-lcells.bsky.social with footage from Hunter Sowards lab visit www.tiktok.com/t/ZP82fpRCA/

Thanks to all the co-authors and collaborators! I also want to point out the important contribution of our transgenic (not transgender) mice to this study.

Our data especially highlight the importance of studying sex differences in how individuals cope with stress.

FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice - Nature Communications Early life stress can induce lasting changes in brain function and behavior. Here, authors show that glutamatergic FKBP51 specifically in females mediates adaptive stress effects on anxiety and cognit...

New paper: We show that especially female mice benefit from moderate early life adversity under stressful situations in adulthood. This pro-resilient effect requires the psychiatric risk factor FKBP51, which turns out to be also required for adaptive stress responses. www.nature.com/articles/s41...

Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis - Nature Communications Early life experience modulates stress resilience in later life. Here the authors show that maternal care triggers microglia-derived IGF-1 levels, which suppresses the neuronal C/EBPβ-DRP1 axis, promo...

Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis
www.nature.com/articles/s41...