Mathias V. Schmidt

Looking forward to this exciting conference. If you are interested in the latest science on the developmental origins of mental illness, join me and my co-chair @talliezee.bsky.social for our session on Sunday morning at 11:20am.

Very happy to share our new paper in Biological Psychiatry, showing that Urolithin A reverses high anxiety by repairing mitochondrial function in the nucleus accumbens.

Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators!

🔗 Paper: doi.org/10.1016/j.bi...

Astrocytic glutamate regulation is shaped by adversity and glucocorticoid signalling Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear. Here, we probed the di...

Latest lab preprint! Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear... so we dived in:

www.biorxiv.org/content/10.1...

Important initiative 👇

Ready for some really hot 🔥🥵 data on stress and trauma effects across the life span, join us at the 17:30 symposium @ebbsociety.bsky.social with @biancasilvalab.bsky.social.

The heat won’t stop the energy — science (and fans!) in full swing!
🔆🪭💪
#EBBS2025

In Bordeaux for the #EBBS meeting. Looking forward to 4 exciting days of science

Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides Steroid hormones and neurosteroids (collectively neuroactive steroids), alongside neuropeptides, are key modulators of the central nervous system. The…

🚨 NEW PAPER 🚨
Thrilled to share our latest work in "The Neurobiology of Stress" where we highlight the intricate roles of neuropeptides and neurosteroids in psychiatric disorders, & how new technologies can answer old questions about these important signallers. sciencedirect.com/science/arti...

The Be Open about Animal Research Day is starting now!
Show your support and share on #BOARD25

Events — Neurobiology of Grief International Network

🎉It's happening - The Neurobiology of Grief International Network (NOGIN) comes to Europe! We are happy to host NOGIN from Sept 17-19 in Regensburg/DE. Registration is already open, seats are strictly limited to 100 participants. More information here:
www.neurobiologyofgrief.org/events

The evolving neurobiology of early-life stress This review explores the effects of early-life stress on brain development and cognitive function, highlighting gaps in understanding perceived stress, vulnerable developmental stages, underlying mole...

Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...

Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry Autoimmune diseases are a heterogeneous category of disorders caused by an interaction between genetic and environmental factors which lead to a dysre…

Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry www.sciencedirect.com/science/arti...

Early Life Stress Can Build Resilience in Females Stress in early life can improve emotional regulation and cognitive function in female mice. This is a significant departure from the traditional view that such stress is solely detrimental. The study...

Read about our recent discoveries on mechanisms that can drive resilience in females.
www.psych.mpg.de/2949097/news...

So well deserved! Congratulations 👏🏻👏🏻👏🏻

The Peter Seeburg Integrative Neuroscience Prize honors groundbreaking work that bridges molecular & systems neuroscience to advance our understanding of cognition, emotion, memory, & decision-making. 🔬 Celebrate bold science. Nominate now.
#Neuroscience #BrainResearch

www.sfn.org/careers/awar...

Intergenerational Effects of Stress – A Focus on Learning and Memory Stress is a ubiquitous facet of life. Ranging in form (e.g., psychosocial, physical, nutritional, economic) and longevity (e.g., acute, chronic), stressors affect the biology of those directly in thei...

Intergenerational Effects of Stress - A Focus on Learning and Memory
doi.org/10.1007/7854...

lab but aesthetic 🤩 comment how a typical day looks for you #sza #dayinlife #interviews #science #lablife #labtech #behindthescene TikTok video by trainor lab

We're using a lab TikTok account to try and get the message out about why science is important. The latest post from @neurani.bsky.social and @g-lia-lcells.bsky.social with footage from Hunter Sowards lab visit www.tiktok.com/t/ZP82fpRCA/

Thanks to all the co-authors and collaborators! I also want to point out the important contribution of our transgenic (not transgender) mice to this study.

Our data especially highlight the importance of studying sex differences in how individuals cope with stress.

FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice - Nature Communications Early life stress can induce lasting changes in brain function and behavior. Here, authors show that glutamatergic FKBP51 specifically in females mediates adaptive stress effects on anxiety and cognit...

New paper: We show that especially female mice benefit from moderate early life adversity under stressful situations in adulthood. This pro-resilient effect requires the psychiatric risk factor FKBP51, which turns out to be also required for adaptive stress responses. www.nature.com/articles/s41...

Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis - Nature Communications Early life experience modulates stress resilience in later life. Here the authors show that maternal care triggers microglia-derived IGF-1 levels, which suppresses the neuronal C/EBPβ-DRP1 axis, promo...

Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis
www.nature.com/articles/s41...

Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoids Chronic exposure to glucocorticoids during brain development leads to priming of the inhibitory neuron lineages in organoids.

🚨🧠 New paper alert: Stress alters neuronal balance in the developing brain 🧠🚨

Our latest study in @science.orgAdvances explores how glucocorticoid exposure—a key environmental risk factor—shapes early human brain development using #organoids.
@mpi-psychiatry.bsky.social @drcricru.bsky.social

🧵👇

Very interesting paper on social behavior analysis 👇🏻

European Neuroscience Societies stand up for science to support our U.S. colleagues 💪🏻

GSRNet - Empowering collaboration and knowledge sharing The Global Stress & Resilience Network (GSRNet) is a global community connecting stress and resilience researchers and national networks.

A new initiative to connect #stress and #resilience researchers around the world. A global platform, needed more than ever in these times: gsr-net.org @gsrnet.bsky.social

Resources to learn, teach, find labs, methods, conferences, workshops, jobs. Benefits for early-career researchers.

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A dual-pathway architecture for stress to disrupt agency and promote habit - Nature Adaptive decision-making often requires an understanding of our agency in a situation; however, chronic stress can disrupt agency and promote inflexible, habitual behaviour by turning off a brain path...

🚨📃New Wassum Lab Paper📃🚨

Out today, @jackiegio.bsky.social discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇

www.nature.com/articles/s41...

Free full text: rdcu.be/eaxEv

Remember, EuropePMC is actually better than #PubMed because it includes ALL preprints in search results, not just those including NIH-funded research.

europepmc.org

The systematic undermining of science by the US administration is absolutely horrifying. The global science community needs to stand up for science and support our US colleagues in this time of crisis.

Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations - Nature Neuroscience The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...

So excited to share the work of the fantastic Katarzyna, 1st 🧪PhD student of my lab 🧠, out in @natureneuro.bsky.social 🥂🥳
Cheers to the team, thanks to our precious collaborators and support from @braincanada.bsky.social #CIHR @fondsrechercheqc.bsky.social #newPI

www.nature.com/articles/s41...