Bill Lagor

Me too. R01 non-competing renewal 4/1- no news. Plus 2 percentile new R01, past Sept Council, 7 months overdue for NOA. NIH remains frozen.

If you want something truly disgusting do that same thing but swap the beef for canned tuna. We had that maybe once every two weeks, usually before pay day.

Kids just don't know how good they have it!

It's Friday- can't wait to see what completely unnecessary anti-science disaster befalls us. Liquor store on the way home...

This is why we need more NIH investment in gene editing and delivery systems. The long-term payout is huge, but needs to be de-risked and more cost effective first. That needs to happen with govt investment that is not tied to the whims of shareholders.

Stay strong colleagues at NIH!

We all appreciate you and the incredible work you do- especially right now.

💪

Still waiting on a 2 percentile R01 at NIDDK that went through Council is Sept.

Is anything coming out of DDK for new awards?

A person in a mask holding a painting that says “hands off my transgenic mice”

At @standupforscience.bsky.social and the signs are statistically significantly excellent

We need one that is just poppy seed and sesame seed combo. Everything else on there sucks.

Go birds!

DOJ, HHS, ED, and GSA Announce Initial Cancellation of Grants and Contracts to Columbia University Worth $400 Million Today, the Department of Health and Human Services (HHS), Department of Education (ED), and the U.S. General Services Administration (GSA) announced that through their coordinated efforts they would i...

I don't even know what to say...

www.gsa.gov/about-us/new...

So is there any way to challenge the frozen federal register blocking NIH study sections? Or are we all just stuck at the mercy of the administration indefinitely?

a man with a mustache is sitting on a swing in a park ALT: a man with a mustache is sitting on a swing in a park

Have a fundable score in the current era

Great lunch to celebrate or recent papers in Sci Transl Med and Molecular Therapy!

Scatterplot titled “Empirical Evidence of Ideological Targeting in Federal Layoffs: Agencies seen as liberal are significantly more likely to face DOGE layoffs.” • The x-axis represents Perceived Ideological Leaning of federal agencies, ranging from -2 (Most Liberal) to +2 (Most Conservative), based on survey responses from over 1,500 federal executives. • The y-axis shows Agency Size (Number of Staff) on a logarithmic scale from 1,000 to 1,000,000. Each point represents a federal agency: • Red dots indicate agencies that experienced DOGE layoffs. • Gray dots indicate agencies with no layoffs. Key Observations: • Liberal-leaning agencies (left side of the plot) are disproportionately represented among red dots, indicating higher layoff rates. • Notable targeted agencies include: • HHS (Health & Human Services) • EPA (Environmental Protection Agency) • NIH (National Institutes of Health) • CFPB (Consumer Financial Protection Bureau) • Dept. of Education • USAID (U.S. Agency for International Development) • The National Nuclear Security Administration (DOE), despite its conservative leaning (+1 on the scale), is an exception among targeted agencies. • A notable outlier: the Department of Veterans Affairs (moderately conservative) also faced layoffs despite its size. Takeaway: The figure visually demonstrates that DOGE layoffs disproportionately targeted liberal-leaning agencies, supporting claims of ideological bias. The pattern reveals that layoffs were not driven by agency size or budget alone but were strongly associated with perceived ideology. Source: Richardson, Clinton, & Lewis (2018). Elite Perceptions of Agency Ideology and Workforce Skill. The Journal of Politics, 80(1).

The DOGE firings have nothing to do with “efficiency” or “cutting waste.” They’re a direct push to weaken federal agencies perceived as liberal. This was evident from the start, and now the data confirms it: targeted agencies overwhelmingly those seen as more left-leaning. 🧵⬇️

Waiting on one from Council on Sept 11 still

Congrats to Marco for making the cover of Science Translational Medicine!

That was a really good series. Shockingly parallel to current events

Snow in Pearland TX

Which would you rather do during this busiest time of the Year?

a) 3 yr IACUC renewal
b) NIH progress report
c) get root canal

Two big papers accepted this week!!! So proud of my lab and grateful for outstanding collaborators. Details to follow as these go to press...

Can anyone provide some guidance on the best LNP formulation for delivery of a 6 kb base editor mRNA to murine liver? A literature reference that actually mentions methodological details would be amazing! Thanks 🙏

I don't understand how biotech has become winner-take-all/ there-can-be-only-one. There should be multiple solutions and options for SCD gene editing, from many companies. Plenty of room.

More like the college's grants office submitted minutes before the deadline... even though you had it to them 2 weeks early

💯👇

Pro tip for those starting a new lab. If you think you need 2 -80C freezers, buy 3. Because sh*t happens.

Marco sighted in the wild at AASLD. Great job on earning a Pinnacle grant for this project!

👏 congrats

Run into this a couple of times myself. Passenger mutations are an underappreciated explanation for many mouse phenotypes

Looking to connect with other scientists interested in: gene therapy, Genome Editing, lipids, cardiovascular disease, metabolism, Molecular biology, liver, bioengineering, and most anything else involving cool science.

Please like and I'll follow you.

Test post. Let's talk science!