Aleesa Schlientz

The last @odlab.bsky.social poster is today! Go see @nehavarshney.bsky.social about worm embryo development gone wrong 😱

Today's the day! If you're at #CellBio2025, come visit my poster to learn more about Aurora B and cytokinesis. Afterwards, check out the posters from the other OD lab members attending the conference 🥳

Cell Proliferation and Gene Editing Unit Every day, millions of cells divide to sustain essential tissue functions. Errors in this process can lead to developmental disorders or cancer. Our research focuses on the molecular mechanisms of cel...

We’re recruiting a Postdoctoral Researcher at OIST (Okinawa, Japan) to explore how mitotic stress shapes aging.

If you’re excited about cell biology, aging, and mechanistic discovery, we’d love to hear from you.

More info: www.oist.jp/careers/post...

Website: www.oist.jp/research/res...

We are very excited to present our work at #CellBio2025! Mark your calendars and check out some fantastic posters from our lab members @nehavarshney.bsky.social @aleesaschlientz.bsky.social @dorinehintzen.bsky.social & @jiaweixu.bsky.social. Looking forward to reconnecting with the #ASCB community!

The mitotic stopwatch synergizes with mild p53 activation to halt cell proliferation https://www.biorxiv.org/content/10.64898/2025.12.02.691971v1

Tell your undergrads about this. It’s a fantastic short-course in Ann Arbor, all expenses covered. Do some experiments in developmental biology and learn about careers in research and life as a grad student 🧪

Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on.

(Please repost to reach a broad audience.)

My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...

Awesome, looking forward to it!

This is really cool! Is there any way to make the display range Min/Max boxes in the Channels & Contrast menu fillable/editable? So if someone wants to manually input a specific display range they can do it right in that window without having to go through the B&C window as well?

A chromatin-associated pool of Aurora A controls kinetochore-microtubule attachments to ensure chromosome biorientation https://www.biorxiv.org/content/10.1101/2025.10.31.685952v1

@joann-trejo.bsky.social, @marymunson4.bsky.social and I have a commentary in @natcellbio.nature.com on recent attacks on DEI in biomedical research: "If scientific research, especially biomedical research, is meant to serve everyone, then it requires that everyone has an opportunity to participate"

New paper from the lab! Many animal cells exhibit chiral cell surface dynamics, which are proposed to drive left–right asymmetric patterning. However, the molecular mechanisms linking these events remain unclear. authors.elsevier.com/a/1l%7E7B3QW...

Donate to Paul Maddox for Congress in NC 11 Paul is running for Congress because there’s a sickness in Washington, and no one is working to cure it.

Dear all, A scientist from UNC Chapel Hill, Paul Maddox, is running for congress in NC for a seat currently held by a republican. If you care about science (and democracy) please consider donating to his campaign #Standupforscience secure.actblue.com/donate/paul-...

headshot of Austin Seroka

Vagal axons extending towards organ targets during development

.@austinseroka1.bsky.social of Fred Hutchinson Cancer Center will kick off the #SDBPostdocSeminar with his talk "Transcription factor code specifies vagal motor innervation of organ targets during development" Image: Vagal axons extending towards organ targets during development

🚨JOB ALERT🚨

FRIENDS PLEASE SPREAD and RT

We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.

See below 2 calls👇

Now out on bioRxiv. 🥳My research on #cytokinesis, averaging thousands of #ExM images🔬, creating a dynamic atlas of cytokinesis 🦠⏳. Here's an animated sneak peek of what we found. Better resolution on bioRxiv😄 #PSFoftheGIF


1/6 Extremely happy to share my PhD work is out on bioRxiv! We discovered that microtubules deform mitotic centrosomes. When we removed them, the SPD-5 scaffold became denser but didn't lose material. This suggests it's an elastically deformable solid! This only happens in mitosis.

I am honored to be selected as a winner of a 2025 MBoC Early-Career Paper Award for my recent work on the role of kinetochores in establishing neuronal architecture. Thank you to my supervisor @dcheerambathur.bsky.social and co-authors! @ascbiology.bsky.social
www.molbiolcell.org/doi/full/10....

Hybrid incompatibility emerges at the one-cell stage in interspecies Caenorhabditis embryos Bloom et al. show that hybrid incompatibility between Caenorhabditis elegans group nematode species pairs arises immediately after fertilization, before zygotic gene expression. Primary defects in spe...

Our recent study exploring the mechanisms behind hybrid incompatibility in Caenorhabditis Elegans nematodes is now available at @currentbiology.bsky.social!

Many thanks to my collaborators at UCSD - @odlab.bsky.social @greenbeegreen.bsky.social and the Rifkin Lab!
www.cell.com/current-biol...

How do species remain distinct? Our recent collaboration with the Rifkin Lab discovered a new hybrid incompatibility between Caenorhabditis species that results in defects in the first cell division, like irregular spindles! We show how subtle changes in cell biology can reinforce species barriers.

Advertisement for remaining posters from the Oegema/Desai lab at the international worm meeting. Aleesa is presenting two cytokinesis posters (262C/263C), Neha is presenting a poster on protein phosphatase 1/inhibitor l-2 (278C).

Today at #Worm25 come visit me at posters 262C/263C for a cytokinesis double feature!

Long-term ex ovo culture of Caenorhabditis elegans embryos The genetic tractability, transparency and invariant development of the C. elegans embryo have led to its broad adoption as a model system for the study of cell and developmental biology. Its impermea...

New preprint! Grad student Clover Stubbert and undergrad Cherry Soe worked out a serum-free media that sustains eggshell-less C. elegans embryos all the way through development, now making it possible to access any embryonic developmental stage with small molecules
www.biorxiv.org/content/10.1...

The Oegema/Desai labs are heading to #Worm25! Mark your calendars and check out the talks/posters from our current lab members @greenbeegreen.bsky.social @nehavarshney.bsky.social @aleesaschlientz.bsky.social and Wanying Tian!

We are excited to share our latest work on the role of anillin during unilateral cytokinesis. Congratulations to Mikhail, the leading author, for his excellent work. Big thanks to the @tdvalilab.bsky.social lab for their tremendous support.

Every one of my friends is asking “do I even have a career going forward”

A sperm-oocyte protein partnership required for egg activation in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.01.23.634539v1

Genetic Engineering and Screening Using Base Editing and Inducible Gene Knockout Genetic engineering and screening in human cells are powerful techniques for the precise and comprehensive identification and analysis of gene and protein domain functions. Genome-wide knockout screen...

Interested in Base Editing and Genetic Screening?
Check out our method chapter: link.springer.com/protocol/10....
Esther Ng did an excellent job developing these methods in our lab. The constructs will soon be available on @addgene.bsky.social
Many thanks to OIST for supporting open access!

Check out these PAID summer internships and other opportunities for undergraduates and graduate students.
www.pathwaystoscience.org

Interested in the “mind blowing” 🤯 function of Protein phosphatase 1 beta during C elegans embryonic development!!! Come by my microsymposium talk and poster [B348] today at #cellbio2024!