Zachary H. Gursky

When #halloween meets #FluorescenceFriday 🎃

Absolutely fantastic work on an underappreciated pocket of the brain and body! (Our understanding of) Meningeal macrophages get cooler every day!

Such an interesting experiment exploring interplay between cognition and basic bodily functions, like breathing.

🧵3/3 And of course, none of this would have been possible without postdoc mentor Helene Benveniste, co-lead author Zohaib Khan🥇 @weillcornell.bsky.social and MANY others including the incredible, late, Allen Tannenbaum. Looking forward to more exciting brain-immune 🧠🦠🥼 research? Keep an eye out 👀😉

🧵2/3 Previous work shows CSF-lymph coupling can be affected by lifestyle 🚴🫀x genetics🧬 and *may* cause neurodegeneration with age/injury. An accompanying commentary from @laurenhablitz.bsky.social www.jci.org/articles/vie... highlight link between peripheral injury, brain health, and immune system.🦠

🧵1/3 Excited for my recent 🧪research out at @jclinical-invest.bsky.social! At @yaleschoolofmed.bsky.social Anesthesiology, we manipulated coupling between brain (cerebrospinal fluid🧠💧[CSF]) and cervical lymph vessels. We saw age-based drainage changes, ⬆️📈neuroinflammation and ⬇️📉brain homeostasis.

Shari Wiseman standing in front of a room and speaking to trainee scientists, mostly postdoctoral researchers and graduate students.

A different angle of Shari Wiseman standing in front of a room and speaking to trainee scientists, mostly postdoctoral researchers and graduate students.

It is great to welcome @shariwiseman.bsky.social (back) to Yale along with the Yale Neuro Postdoc Committee [YNPC], @kavliatyale.bsky.social, and @yaleneuro.bsky.social ! Pictures are of her first talk to a packed room of trainees, about scientific publishing and related careers

This is a great opportunity for any postdoc with a scientific story that they want to share and a drive to meet more researchers in the field! I highly recommend applying even if you are uncertain

Very excited to contribute to this recent review where we discuss ways in which the immune system interacts with the brain, focusing on inhibitory neurons of the cortex!
authors.elsevier.com/c/1lWWR3Q9h2...

Picture of symposium room with podium. Two projector screens on the sides of the podium say "Kenneth Rainin Foundation 2025 Innovations Symposium" with a picture of Turtle Bay Oahu, Hawaii.

Picture of Zachary Gursky, smiling, holding a name tag that says "Kenneth Rainin Foundation 2025 Innovations Symposium, Zachary Gursky, Yale University, Grantee"

Excited to be representing the @emiliafavuzzi.bsky.social lab at @krfoundation.org 's 2025 Innovations symposium! If you're here, feel free to say hi and come talk about brain-immune system interactions! #idb #brain #neuroscience #immunology #research #scicomm

Very interesting preprint on ligand-independent activation of GABA-B receptors (GPCRs more broadly?) by mechanical force transduction in the brain! Could this mechanism be at play in GABAergic circuits elsewhere in the body, as well?

Exciting finding led by a group here at Yale. Just because you might not find a lot of T cells in the brain tissue typically doesn't mean they aren't highly influential! And this is one source of them

Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development Nature Neuroscience - The choroid plexus (ChP) provides molecular cues for brain development. However, the underlying mechanisms are unclear. This study identifies an apocrine secretion mechanism...

Led by @scienceyael.bsky.social & out today in @natneuro.nature.com: the brain's fluid-secreting organ — the choroid plexus — can reshape neural development through a powerful, little-known process. & it can be hijacked by serotonergic drugs like LSD. 🧠👇 A thread
rdcu.be/eoaSY

It may be tempting to see "AI" (as vague and nebulous as that term is) as an answer; a means to an end. Instead, consider it one of many tools in a collection of expertise that must be refined and combined with our knowledge, experience, and humanity toward the futures we want. Sensibly.

"If the only tool you have is a hammer, it is tempting to treat everything as if it were a nail." -Maslow, 1966

Just attended a college graduation where the majority of speeches referenced the necessity and inevitability of AI (when AI was not in curricula). Very interesting choice to prioritize this over the academic efforts and achievements of the new graduates.

CSF transport at the brain–meningeal border: effects on neurological health and disease The existence of specialised structures that allow a continuous exchange of CSF between different anatomical compartments at the brain–meningeal border is challenging conventional notions around molec...

www.thelancet.com/journals/lan...

Congrats @siararouzer.bsky.social ! Keeping FASD research represented for the Gordis

4/10 Using experimental manipulations, we found that PV interneurons scale the inhibition they receive to maintain stability. When the activity of a PV interneuron increases, it “requests” more inhibitory inputs from other PV+ interneurons, effectively rebalancing its activity

🚨Registrations now live!
Check out this amazing line up of speakers at #RTN #ReThinkNeuroimmunology organised by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Register here: genelayinstitute.org/rtn/

alie ward

Just a reminder that if you’re an ologist or passionate expert in something (or have someone to suggest) shoot your friggin shot on this app & tweet me.

I may not get to interview everyone but I love knowing whom’s whom. 🎤💚🎧

(oh but check to see if we’ve already covered it: www.ologies.com)

I'm excited to host Dr. Pandey tomorrow for what will certainly be an outstanding talk! Thanks to @kavliatyale.bsky.social and @yaleneuro.bsky.social for providing the opportunity to bring in our scientific peers and connect postdocs and facilty across institutions

Meningeal lymphatics-microglia axis regulates synaptic physiology Meningeal lymphatics serve as an outlet for cerebrospinal fluid, and their dysfunction is associated with various neurodegenerative conditions. Previo…

Excited to share our work by exceptional postdoc, Kyungdeok (KD) Kim. 2025 marks 10th anniversary of meningeal lymphatic discovery and I can’t be happier celebrating it with this work addressing how lymphatic dysfunction leads to cognitive deficits ||

www.sciencedirect.com/science/arti...

Today, I donated blood for the first time in my life with @americanredcross.bsky.social. I have always been wildly uncomfortable around needles and particularly IVs, but the world needs more people helping each other right now. Be kind to those around you, and help where you can.

Excited to share the latest work from our lab where we examined the role of pyramidal cells in regulating microglia development!

As per tradition here is a graphical summary of our paper in comic form.

www.science.org/doi/10.1126/...

Interstellate Magazine: The Art of Neuroscience Caitlin Vander Weele has been curating a collection of stunning neuroscience images that really bring the brain to life (so to speak). Volume 1 is here and it is a beauty! You can also download the…

I'm not sure whether this is of interest (probably too complex to be printer-friendly) but @caitvw.bsky.social worked on this beautiful project a few years ago and maybe could help point you to someone involved that might have a more manageable asset? neuroecology.wordpress.com/2016/10/25/i...

Not sure if ebook is available at your library (my local library is linked), but I rather liked: nhave.na2.iiivega.com/search/card?...

Effect of Plasma and Blood Donations on PFAS Levels in Firefighters in Australia This randomized clinical trial examines the effect of blood or plasma donations on serum levels of perfluoroalkyl and polyfluoroalkyl substances among firefighters in Australia.

A recent JAMA Network Open article also suggests that blood donation might also be a helpful and altruistic way! jamanetwork.com/journals/jam...

Since there has been a lot of misinformation circulating since last night, I find this AAMC infographic helpful in illustrating which types of expenses are and are not covered by NIH indirect cost reimbursements.

Picture of Carl Zimmer standing at a podium in tue front of a room, pointing to a powerpoint slide which contains examples of headlines and header images from articles that he wrote for the New York Times.

Excited to hear from @nytimes.com science writer @carlzimmer.com on crafting scientific narratives and scientific storytelling and his ideas on the state of science. #scicomm #science #journalism