Malcolm Sim

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases Abstract. Approximately 10% of peripheral CD4+ cells and less than 1% of CD8+ cells in normal unimmunized adult mice express the IL-2 receptor α-chain (CD2

Congratulations to new Nobel Laureate and AAI Distinguished Fellow Shimon Sakaguchi, co-winner of the 2025 Nobel Prize in Physiology or Medicine for his foundational discoveries on regulatory T cells and peripheral immune tolerance! Published in The JI in 1995: ow.ly/LGk150X7984.

Today we welcome Associate Prof. Amir Horowitz from the Tish Cancer Institute at Mt Sinai to the CIO Seminar Series.

Amir will present work from his group with the title 'Targeting HLA-E and NKG2A in solid tumors to overcome resistance to cancer immunotherapies'

Research Assistant at University of Oxford An opportunity for an academic position as a Research Assistant is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.

We're hiring!

Come join our lab in Oxford as a research assistant and study peptide recognition of MHC molecules - please reach our for more details!

www.jobs.ac.uk/job/DOW691/r...

🎨 After lunch we had some team-building fun with a sciency embossing workshop 🧑‍🎨 so many creative scientists in the room! Huge thanks to Asma for teaching us a new skill!! #CIOawayday #embossing

🧪 We continued with an engaging afternoon poster session featuring more of our talented PhD students 🐣 Fantastic science, thoughtful questions, and great discussions all around. The future is bright! #CIOawayday

🐣 We followed with our Junior PIs telling us about their questions for the next 5 years 💡 Lots of exciting, cutting-edge new ideas that will hopefully materialise soon and bring even more new questions to #CIO 🤓 🥳 #CIOawayday @galvez-cancino.bsky.social @mjwsim.bsky.social

🌟 Fantastic morning poster session from our DPhil students 📚🧫 so much talent and fresh thinking on display! More to come this afternoon. #CIOawayday

✨ Kicking off #CIOawayday with our senior PIs sharing the experiments that changed their careers 🧑‍🔬👩‍🔬🧫 A reminder that serendipity, curiosity, and pub chats can spark groundbreaking ideas 🤓 Clearly science thrives on kindness and collaboration and we got a lot of that in #CIO 😉🙃 #ScienceLife

Atom-level mechanism of tapasin-independent peptide editing by Major Histocompatibility Complex class I molecules https://www.biorxiv.org/content/10.1101/2025.06.20.660712v1

Fascinating preprint from @timmunologist.bsky.social @mjwsim.bsky.social and co-authors

Feeling proud and looking sharp!
Repping the Centre for Immuno-Oncology in style 😎

🔥Our top models, @anthonyhsieh.bsky.social and @mjwsim.bsky.social, rocking the CIO polos, in black and navy, which seems to be the unofficial Friday uniform around here!

Team spirit (and outfits) on point 💛🖤💙

Lucy, FHS student at @mjwsim.bsky.social’s lab, has outdone herself! Not only is this the prettiest cake we’ve seen 😍, but it’s also seriously delicious 🤤🍰 #LabLife #BakingScience

And we're off!!

@timmunologist.bsky.social opens our third annual OCION Symposium ‪@oxfordmathematics.bsky.social today!

Don't forget to visit our sponsors posters/exhibition stands.
@imtadvances.bsky.social (STAND)
@nanoporetech.com (STAND)
@Immunocore (POSTER)
@10xgenomics.bsky.social (STAND)

NK2026 in Italy!

Jet lagged and ready to rock #NK2025 in Tasmania

It’s Wednesday morning. There’s no more new Andor and I’m just supposed to carry on with my life.

Sign the Petition #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK

chng.it/ZYvmHTMZnJ

Sign the Petition #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK

Please sign this urgent petition to Parliament: #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK chng.it/tsH8ZSJfRH via
@ukchange.bsky.social

Interactions between cancer-associated fibroblasts and the extracellular matrix in oesophageal cancer Stromal components of the tumour microenvironment, such as cancer-associated fibroblasts (CAFs) and the extracellular matrix (ECM), are actively invol…

Delighted to share our review, published in Matrix Biology, led by Subashan Vadibeler, Shannique Clarke & Su Phyu - understanding matrix biology in oesophagogastric cancer is essential to improve therapeutic options, we highlight existing knowledge & gaps here - www.sciencedirect.com/science/arti...

@graphcrimes.bsky.social

Why axes labels are so important.

More supervision = more risk.

Maybe this is what my students think when I’m in lab?

-As part of (another) health & safety training-

Model figure - in EAC cancers, as chromosomal instability (CIN) increases, we found that a CIN-driven cGAS-dependent axis drives myeloid directed chemokine expression and recruitment of tumor-favoring myeloid populations

Incoming - new preprint alert from the Parkes lab led by @brunobeernaert.bsky.social Full bluetutorial follows! 1/ 11 www.biorxiv.org/content/10.1...

🎯 Wanna know how NK cells recognise viruses? Sign-up for this month's @dgfi-yi.bsky.social virtual seminar as we host @quirinhammer.bsky.social, who'll enlighten us on the molecular mechanisms underlying recognition of virus-infected cells by NK cells. Registration👇🏼
docs.google.com/forms/d/e/1F...

Delighted to be hosting the next KIR workshop in Oxford next year. Please save these dates if you're interested. More details to follow.

This year I'll be running 10k, 10 miles and a half marathon to raise awareness (with a just giving page too) for the ME Association - #millionsmissing can't run so I'll do it for them

My thanks to Beining for her help, a research assistant soon-to-be DPhil student in the lab.

Thanks to Oxford Open Immunology for their work arranging reviewers and being patient/flexible with timelines.

Delighted that this review is now accepted and online.

We review evidence from us and others that germline-encoded receptors of the innate immune system can detect peptides presented by MHC molecules, some with high peptide-specificity.

t.co/9EKH2SpGEy

Peptide selectivity of killer cell immunoglobulin-like receptors differs with allotypic variation in HLA class I Abstract. Natural killer (NK) cell activation is regulated by killer cell immunoglobulin-like receptors (KIRs) that recognize human leukocyte antigen (HLA)

academic.oup.com/jimmunol/adv...

🔬CIO is at #BSIOxford today! 🎯 Beinig Li gave a fantastic talk this morning on peptide-specificity of KIR during the Innate Immunity session.
🤓You still have the chance to check out all the CIO insightful posters—lots of cutting-edge science on display! #Immunology #BSI2025

@britsocimm.bsky.social

Beining Li giving a talk

....and thanks to Beining Li for a brilliant talk on the peptide specificity of KIR with yeast display of HLA-C #OIS25 @oxcio.bsky.social