What linking means when installing a Conda package
Package managers face a fundamental challenge: how to efficiently place files from a package cache into multiple environments without excessive disk usage or compromising isolation.
Another deep dive in the technology behind Conda package managers: file linking! Did you know that there are symlinks, hardlinks and reflinks? Reflinks are the best โ copy on write is space efficient and isolates the cache.
Learn more: prefix.dev/blog/what-l...
17.07.2025 12:26 โ ๐ 5 ๐ 3 ๐ฌ 0 ๐ 0
Sassy solves approximate string matching: finding all matches of a pattern in a text.
Sassy is out now!
Ever need to search for approximate matches of short DNA strings?
Sassy is the tool to use!
Available now wherever you get your code
With @rickbitloo.bsky.social
curiouscoding.nl/papers/sassy...
github.com/ragnarGrootK...
18.07.2025 20:20 โ ๐ 36 ๐ 20 ๐ฌ 2 ๐ 2
Itโs come up for me! As a link specifically.
19.07.2025 18:18 โ ๐ 1 ๐ 0 ๐ฌ 0 ๐ 0
Iโve been wondering how Perl would fair with an llm. It manages to pack so much context into so few characters, it kind of seems like it should be great for llms?
I have no idea how to go about proving it is โgoodโ or โbadโ for an LLM though.
19.07.2025 15:51 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0
Thatโs fair! And I donโt have any better solutions.
Based on the linked AVX2 feature share in my other reply, hopefully we can widen the โgenericโ simd support in compilers here at some point
13.07.2025 00:29 โ ๐ 2 ๐ 0 ๐ฌ 0 ๐ 0
* cited ๐คฆ
13.07.2025 00:27 โ ๐ 2 ๐ 0 ๐ฌ 0 ๐ 0
* sited, not sites
12.07.2025 23:50 โ ๐ 1 ๐ 0 ๐ฌ 1 ๐ 0
Graphics Survey
They support/ run CI for the large Hw groups like Linux-64, linux-aarch, osx-64, etc.
Some good HW stats: firefoxgraphics.github.io/telemetry/#v...
Sites here: linebender.org/blog/a-plan-...
If v3 is around 75% in consumer PC, itโs got to be 90%+ for the HW for BFX
12.07.2025 23:44 โ ๐ 1 ๐ 0 ๐ฌ 2 ๐ 0
That compiles it on the CI machine I believe, so you canโt target the end user CPU features :(
You kind of can with conda features, but itโs a big pain and not standard that I can tell.
It causes me great pain that all these tools we install with conda are basically stuck with sse only
12.07.2025 23:28 โ ๐ 2 ๐ 0 ๐ฌ 1 ๐ 0
I was trying to be gracious by calling them "user thoughts". reddit's gonna reddit
08.07.2025 19:05 โ ๐ 1 ๐ 0 ๐ฌ 1 ๐ 0
It might have been about array/range and their relationship with Iterator/IntoIterator
08.07.2025 18:50 โ ๐ 2 ๐ 0 ๐ฌ 1 ๐ 0
Thanks for the reply! I'll keep digging.
08.07.2025 18:50 โ ๐ 2 ๐ 0 ๐ฌ 1 ๐ 0
*be imagining it
08.07.2025 17:35 โ ๐ 2 ๐ 0 ๐ฌ 0 ๐ 0
@steveklabnik.com Did you write an article about ways you wish Rust Iterators had evolved differently? Or remember who wrote that?
Mojo is about to start in on its iterator abstraction and I was looking for lessons learned from Rust, but can't find that article.
I might be imagining this it ๐ฌ
08.07.2025 17:34 โ ๐ 10 ๐ 0 ๐ฌ 2 ๐ 0
Looking for papers to cite for tight definitions of global alignment, semi-global alignment, and mapping...
I would probably be the person to ask, yet here we are.
07.07.2025 14:55 โ ๐ 3 ๐ 2 ๐ฌ 1 ๐ 1
Catching up on some releases:
Perbase 0.10.3: bugfix for --mate-fix when MAPQ scores are equal github.com/sstadick/per...
rust-lapper 1.2.0: fix to the BITS count algorithm for 25-30% improvement in perf github.com/sstadick/rus...
03.07.2025 09:26 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0
Happy if-let-chain stabilization day to all those who celebrate!
26.06.2025 14:59 โ ๐ 4 ๐ 5 ๐ฌ 0 ๐ 0
ExtraMojo update is live! Two added datastructures with BitVec and BBHash.
Updated for Mojo 25.4.
extramojo.github.io/ExtraMojo/Ex...
extramojo.github.io/ExtraMojo/Ex...
github.com/ExtraMojo/Ex...
25.06.2025 18:37 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0
ish v1.2.0 released and available via conda!
github.com/BioRadOpenSo...
Updates to Mojo 25.4
Bugfix for AVX512 on short queries
Improvement for saturating arithmetic to use LLVM intrinsics.
25.06.2025 18:35 โ ๐ 1 ๐ 0 ๐ฌ 0 ๐ 0
FastGA: Fast Genome Alignment https://www.biorxiv.org/content/10.1101/2025.06.15.659750v1
20.06.2025 05:47 โ ๐ 5 ๐ 2 ๐ฌ 0 ๐ 0
The Gap Through Which We Praise the Machine
My current theory of agentic programming: people are amazing at adapting the tools they're given and totally underestimate the extent to which they do it, and the amount of skill we build doing that i...
Why do some have a shit time with LLMs for programming while others love it?
To succeed, the latter group tacitly creates tons of scaffolding and gain weird new skills. While it works, this posts explains how doing all that is an incidental consequence of bad interaction design in coding AI agents.
09.06.2025 13:14 โ ๐ 149 ๐ 53 ๐ฌ 5 ๐ 17
What's new | Modular
Release notes for each version of the Modular platform.
Mojo 25.4 is out!
This is the version where the beta version of Python bindings is live ๐ฅ
docs.modular.com/max/changelog/
18.06.2025 21:57 โ ๐ 1 ๐ 0 ๐ฌ 0 ๐ 0
Well worth 10 minutes to read this. I had no idea that's how they worked.
11.06.2025 13:23 โ ๐ 2 ๐ 0 ๐ฌ 0 ๐ 0
Hashing - The Rust Performance Book
Yearly PSA: you probably don't actually want to be using the builtin HashMap hashing algo in Rust stdlib.
nnethercote.github.io/perf-book/ha...
10.06.2025 16:25 โ ๐ 2 ๐ 0 ๐ฌ 0 ๐ 0
Comparison of manual version vs instrinsic: mojo.compiler-explorer.com/z/z3xrzK1Tr
Note that in both cases it correctly reduces to the single instruction. The win is that we don't have to rely on the compiler pattern matching that, and don't have to wait on the compiler to implement it.
10.06.2025 13:54 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0
@prefix.dev software engineer who loves languages and trains ๐
CS PhD student at UMD. Interested in Computational Biology. Views driven by an unknown combination of previously consumed material (weights are dynamic).
Previously at Genentech, IIIT-Hyderabad
Bio/Cheminformatics, Genomics, Drug Discovery
assistant professor @NYU Courant CS :: programming languages :: parallel computing :: music :: lead dev of the MaPLe compiler (https://github.com/mpllang/mpl)
https://cs.nyu.edu/~shw8119/
Staff SRE @ honeycomb.io, Tech Book Author, Resilience in Software Foundation board member, Erlang Ecosystem Foundation co-founder, Resilience Engineering fan. SRE-not-sorry.
blog: https://ferd.ca
notes: https://ferd.ca/notes/
tag or dm for submissions
support: https://www.patreon.com/TheLouvreofBluesky
Binomica Labs independent researcher by day, warehouse worker by night
Small thoughtful science
#phylogenetics #archaea #sequencing #bioinformatics
@naturepoker@genomic.social
http://naturepoker.wordpress.com
https://orcid.org/0000-0002-6977-5440
Founder Tech For Palestine, Darklang, and CircleCI. Currently running Tech for Palestine https://techforpalestine.org
EPIGENETIC HULK SMASH PUNY GENOME. MAKE GENOME GO. LOCATION: NOT CENTROMERE, THAT FOR SURE
Occasional OCaml programmer. Host of Signals and Threads http://signalsandthreads.com
Interested in infectious disease informatics. Research fellow at the University of Birmingham. Also cycling, photography, active travel. https://bede.im
bioinformatics phd candidate @ ucsc
https://github.com/cademirch
Mostly 3D+AI+voice.
Currently building https://playmixworld.com and https://mixreel.ai
Also:
https://github.com/nmfisher/thermion
https://bit.ly/3RkzFfH
Flutter/Dart/C++/PyTorch/Blender
Pathogen informatics and modelling http://bacpop.org
(Research group leader at EMBL-EBI - http://ebi.ac.uk/research/lees/)
Exploring heterogeneous computation at Modular. Out here in the Wisconsin woods with two pugs and @redqueencoder.bsky.social
LLVM Project News and Details from the Trenches
[bridged from https://blog.llvm.org/ on the web: https://fed.brid.gy/web/blog.llvm.org ]
A community led collection of recipes, build infrastructure and distributions for the conda package manager.
https://conda-forge.org