Uropathogenic E. coli uses a novel two-gene system, DanRI, to outsmart neutrophils by blocking NETs and ROS. Induced by host nucleosomes, DanRI boosts bacterial survival & persistence. A new twist in immune evasion!
βοΈ @doracerina.bsky.social & coll.
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12.06.2025 11:38 β π 4 π 1 π¬ 1 π 0
Huge thanks to everyone on the team who made this possible!
16.06.2025 08:42 β π 0 π 0 π¬ 0 π 0
In our study, we discovered a previously unknown two-gene system in UPEC that we named DanRI (Defense against neutrophil Regulator and Inhibitor). This system is turned on by NETs and helps the bacteria block neutrophil attacks. Without DanRI, UPEC struggles to survive and persist during infections.
16.06.2025 08:41 β π 0 π 0 π¬ 0 π 0
The main culprit behind urinary tract infections is a strain of E. coli known as UPEC. To survive in the body, UPEC has to evade our immune system, especially neutrophils, a type of immune cell that traps and kills bacteria using web-like structures called NETs.
16.06.2025 08:41 β π 1 π 0 π¬ 0 π 0
The main culprit behind urinary tract infections is a strain of E. coli known as UPEC. To survive in the body, UPEC has to evade our immune system, especially neutrophils, a type of immune cell that traps and kills bacteria using web-like structures called NETs.
In our study, we discovered a previously unknown two-gene system in UPEC that we named DanRI (Defense against neutrophil Regulator and Inhibitor). This system is turned on by NETs and helps the bacteria block neutrophil attacks. Without DanRI, UPEC struggles to survive and persist during infections.
We're excited to share our new preprint on bioRxiv! β¨
You can view it here: www.biorxiv.org/content/10.1...
See below for more information π
16.06.2025 08:40 β π 2 π 1 π¬ 3 π 0
Histone H1 kills MRSA
Marsman etΒ al. detect histone H1 in MRSA in human abscesses and demonstrate that it
kills MRSA under physiological conditions. They identify through selective evolution
and a genome-wide screen that h...
π¨ Paper alert! Happy to share the new publication by the Zychlinsky Lab (@mpiib.bsky.social) and Torres Lab (@torreslab.bsky.social) with the succinct but effective title "Histone H1 kills MRSA".
You can find the paper here: www.cell.com/cell-reports...
15.11.2024 12:44 β π 10 π 6 π¬ 0 π 1
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