Sophie Chauvet

🌴😎🌊 🩴 | Aix Marseille Université vous souhaite un bel été !

Nous marquons une pause en cette fin d'année universitaire
On se retrouve à la rentrée avec plein de nouveautés !

Passez de bonnes vacances🙏

Precisely defining disease variant effects in CRISPR-edited single cells - Nature A plate-based assay called CRAFTseq has been developed that uses ‘multi-omic’ single-cell RNA sequencing and direct genotyping of CRISPR edits to test the functional effects of genetic variants on cell state and function.

Nature research paper: Precisely defining disease variant effects in CRISPR-edited single cells

go.nature.com/44M3ygX

Association between ultra-processed food consumption and lung cancer risk: a population-based cohort study Background The evidence on associations between ultra-processed foods (UPF) and lung cancer risk is limited and inconsistent. Research question Are UPF associated with an increased risk of lung cance...

Ultraprocessed food intake and increased risk of lung cancer thorax.bmj.com/content/earl...

Integrated single-cell and spatial transcriptomics uncover distinct cellular subtypes involved in neural invasion in pancreatic cancer Chen et al. integrate sc/snRNA-seq with spatial transcriptomics to characterize cellular composition, lineage dynamics, and spatial architecture in PDAC tissues with varying neural invasion status, un...

Pancreatic cancer cells can hijack neurons to facility their growth and spread. Here's the single-cell map (spatial mics) of the process
www.cell.com/cancer-cell/...

Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from @cssheehan.bsky.social
jci.org/articles/vie... 1/6

Targeting tumor-associated CCR2+ macrophages to inhibit pancreatic cancer recurrence following irreversible electroporation Inhibition of a distinct macrophage subcluster is expected to hinder recurrence of pancreatic cancer after IRE ablation.

Targeting tumor-associated CCR2+ macrophages to inhibit pancreatic cancer recurrence following irreversible electroporation
Science Advances
www.science.org/doi/10.1126/...

Stanford cancer scientists awarded funding for cancer AI A team of Stanford cancer scientists has been awarded to develop AI models that integrate different data types and identify biomarkers to predict whether a patient will respond to a specific cancer…

A team of Stanford cancer scientists has been awarded to develop #AI models that integrate different data types and identify biomarkers to predict whether a patient will respond to a specific #CancerTreatment. med.stanford.edu/cancer/about...

A gut microbiome metabolite promotes atherosclerosis by hijacking the immune system
@nature.com
nature.com/articles/s41...
www.nature.com/articles/d41...

The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets Knol et al. report a large pan-cancer proteome landscape based on high-throughput, single-shot mass spectrometry across 22 cancer types including both liquid (n = 4) and solid cancers (n = 18), revealing co-expression-based phenotypes and immune phenotypes and defining top 25 ranked proteins as potential biomarkers and drug targets for each cancer type as well as a multi-cancer classifier.

The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets

🔬 The next international Developmental Biology course, organized by Institut Curie with @sorbonne-universite.fr, will focus on "From stem #cells to #morphogenesis".

📅 Apply by:
• July 20 (3.5 weeks with hands-on workshop)
• Aug 31 (10 days of seminars)

🔗 training.institut-curie.org/courses/deve...

We’re so excited for the
Cancer Neuroscience EACR conference!
📍Bilbao, Spain
📅 14-16 Oct 2025

‼️Upcoming abstract and travelgrant deadline *June 30th* ‼️

Looking forward to seeing many of you there! 🧠🔬

#cancerneuroscience @helloeacr.bsky.social #neuroscience #cancer

Submit your abstract here 👇

🧠 I am happy to organise on September 29th 2025, with @sophiechauvet.bsky.social, a Symposium "Linking neural development, human disease and evolution" in the Hexagone, Luminy, Marseille.

More detailed for the schedule and registration below!

Help shape the future of research at AMU! Take the foresight survey — your voice matters. @ibdm.bsky.social @ciml.bsky.social @afmblab.bsky.social @inmed.bsky.social @inp-marseille.bsky.social @crcm.bsky.social @mioceanologie.bsky.social @tagc-u1090.bsky.social

👉 Démarche participative d'amU et de ses partenaires sur le site d'Aix-Marseille : les communautés scientifiques sont invitées à participer à un questionnaire de réflexion prospective qui contribuera à éclairer les choix stratégiques dans les années à venir !📈

url.univ-amu.fr/prospective-...

Who Should Be Screened For Pancreatic Cancer Who should be screening for pancreatic cancer? Dr. Allyson Ocean explains how genetic mutations and family history factor into screening.

Who should be screened for pancreatic cancer? Dr. Allyson Ocean explains how genetic mutations and family history factor into screening.

Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity Endoplasmic reticulum to mitochondria Ca2+ transfer is important for cancer cell survival, but the role of mitochondrial Ca2+ uptake through the mitoc…

Article Mitochondrial Ca 2+ controls pancreatic cancer growth and metastasis by regulating ... - goo.gl/alerts/LVVbLH #GoogleAlerts

Pancreatic cancer: Cell discovery opens up new research avenues Researchers at Umeå University, Sweden, have discovered a previously unknown type of connective tissue cells that surround cancer cells in pancreatic tumors.

Pancreatic cancer: Cell discovery opens up new research avenues - goo.gl/alerts/TfmF8Q #GoogleAlerts

Figure showing most common symptoms and signs of pancreatic cancer at diagnosis. Copyright: Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

Pancreatic cancer, often linked to smoking, obesity and diabetes, is predicted to become the 2nd leading cause of cancer-related death by 2030.

A recent Seminar discusses the need for novel therapies & future directions for research: tinyurl.com/ywue2nfs

New @science.org
Exposomics. We're not doing nearly enough to understand and mitigate our toxic environmental exposures. A very insightful perspective
www.science.org/doi/10.1126/...

A visual diagram illustrating the steps in eLife's publishing process: 1. Submission, 2. Peer review, 3. Publication, 4. Author revision, and 5. Final version of record.

Our publishing model emphasises peer reviews, eliminating accept/reject decisions in favour of high-quality, public eLife assessments.

Find out exactly what this new process entails in our process page: buff.ly/TanURTC

Cancer deaths are down 34% since 1991. But, #pancreaticcancer has a 5-year relative survival rate of only 13%, according to the American Cancer Society. It’s time to forge ahead and invest in research to change the future of this devastating disease. Learn more at lfdn.org/forging-ahead

Happy 10th anniversary to our colleagues at @cp-trendscancer.bsky.social 🥳 And what a great way to celebrate than with this special issue! You can't miss it!! 👏👏👏

The Breakthrough Blood Test for Alzheimer's Disease The p-Tau217 Biomarker for Prediction and Prevention

p-Tau217 is a breakthrough blood test that can predict and may help prevent Alzheimer's disease.
erictopol.substack.com/p/the-breakt...
Here's the rundown on it. Free, open-access.

A comprehensive review of cancer survival prediction using multi-omics integration and clinical variables Abstract. Cancer is an umbrella term that includes a wide spectrum of disease severity, from those that are malignant, metastatic, and aggressive to benign

A comprehensive review of cancer survival prediction using multi-omics integration and clinical variables 🧬🖥️ academic.oup.com/bib/article/...

TRIM21-mediated METTL3 degradation promotes PDAC ferroptosis and enhances the efficacy of Anti-PD-1 immunotherapy - Cell Death & Disease Cell Death & Disease - TRIM21-mediated METTL3 degradation promotes PDAC ferroptosis and enhances the efficacy of Anti-PD-1 immunotherapy

TRIM21-mediated METTL3 degradation promotes PDAC ferroptosis and enhances the efficacy of Anti-PD-1 immunotherapy 🧪 www.nature.com/articles/s41...

Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors - Nature Medicine Application of a nanopore sequencing workflow for real-time analysis of brain tumors results in molecular classification within a 30-minute intraoperative window, followed by comprehensive profiling w...

In this week’s publication highlights, we picked this study just out @naturemedicine.bsky.social describing an innovative method for the rapid classification of brain tumors based on molecular profiling.

Congrats to all involved @dkfz.bsky.social and beyond 👏🏻

www.nature.com/articles/s41...

An ultraconserved snoRNA-like element in long noncoding RNA CRNDE promotes ribosome biogenesis and cell proliferation Cancer cells frequently enhance ribosome production to support rapid growth. Here, Lee et al. demonstrate that an isoform of lncRNA CRNDE containing an ultraconserved element (CRNDEUCE) promotes 60S r...

It's difficult to focus on science with everything going on, but I still enjoy hearing about other people's work here, so I want to continue sharing ours. Congrats to postdoc Jong-Sun Lee for his outstanding work published in @cp-molcell.bsky.social! Details in thread👇
www.cell.com/molecular-ce...

Long thought to have little relevance to ovarian physiology, the rete ovarii may have a role in follicular dynamics and reproductive health.
buff.ly/LbG6Jnn

In pancreatic cancer, a race against time | Cold Spring Harbor Laboratory AI generated voice with David Tuveson’s actual voice Pancreatic cancer is projected to become the second-deadliest cancer by 2030. By the time it’s diagnosed, it’s often difficult to treat. So, for bo...

In pancreatic cancer, a race against time | Cold Spring Harbor Laboratory - goo.gl/alerts/Dur79U #GoogleAlerts

Pancreatic Cysts Associated with Intraductal Papillary Mucinous Neoplasms May Be Safely Monitored with Imaging This review provided data on rates of cyst progression necessitating surgery in certain patients who had IPMN-associated pancreatic cysts.

Pancreatic Cysts Associated with Intraductal Papillary Mucinous Neoplasms May Be Safely ... - goo.gl/alerts/54qyqe #GoogleAlerts