Yap Research group

E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding Epithelial stretching promotes the release of EGF receptor ligands that stimulate ERK activation.

A bit delayed, but excited to still share our latest paper, showing that intercellular forces transduced by E-cadherin activate EGFR-ERK signaling in epithelia by inducing EGFR ligand shedding! Mechanical and biochemical signals can act together within a single, linear cascade! tinyurl.com/mr9mj9j2

Excellent work by @juliaeckert.bsky.social- now online!

What do we see when looking at cells under the microscope? 👉Some are bigger than others, some are elongated and align with the neighbors & others seem to move. Cool, right? But wouldn't it be cooler to quantify these observations?

I'm @juliaeckert.bsky.social. Let's explore some analysis software!‬

Got this fantastic opportunity to attend a special interest symposium at MIMS2025, and present a poster about my ongoing scRNAseq work. Brilliant talks and engaging discussions- thank you Australian and New Zealand Society for Immunology for hosting such an insightful event! #scrnaseq #immunology

How do epithelia adapt to mechanical stresses? What roles do junctional complexes AJs & desmosomes play in this mechanotransduction?

Check out our new review article by @juliaeckert.bsky.social & Virgile Viasnoff, discussing these ideas! 👇

Congratulations Caren - this is wonderful news and we are all delighted.

Congratulations @juliaeckert.bsky.social for this feat!

A TRPV4–dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration Cell migration is crucial for development and tissue homeostasis, while its dysregulation leads to severe pathologies. Cell migration is driven by the extension of actin–based lamellipodia protrusions...

Excited to share our latest work on how Ca²⁺ regulates actin in cell protrusions—now available as a preprint on bioRxiv! 🎉 Huge congrats to Ernest Iu for leading the project, and a special thanks to our amazing collaborators!

www.biorxiv.org/content/10.1...

How is extrusion of infected host cells related to ERK (extracellular signal-regulated kinase) activity?

Hi, I’m @hundsdorfer.bsky.social from the @effiebastounis.bsky.social lab. Let’s follow the recent development of bacterially-infected cell extrusion & mechanochemical ERK activity waves.

Happy to share our new publication in
@naturematerials.bsky.social
on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats
@luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉
www.nature.com/articles/s41...

Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...

This dot is a region that intersect multiple cell junctions in an epithelia. These dots act as tiny anchors of cell contacts and they’re critical for epithelial coherence during homeostasis AND development.

I’m @katecavanaugh.bsky.social and I’ll be your guide on this 🧵 about tricellular vertices.

ICYMI: Discover new insights on chromosome size sensing by kinetochores, mechanical resistance at tight junctions, force-exerting focal adhesions formed by T cells, and how nuclei serve as mechanical bumpers, in our new #Mechanobiology collection 👉 https://buff.ly/3EK0uaq

🚨 We are thrilled to announce our amazing list of keynote speakers!!

@PCusachs
@GeorgHalder
@hirashima0203.bsky.social
@iberd.bsky.social
@johannaivaska.bsky.social
@gijsjekoenderink.bsky.social
@laurentnguyen.com
@renkawitzteam.bsky.social
@Sixt_Lab
...

Epigenetics Gordon Research Conference. Consider joining us for what will be an excellent, exciting meeting and will be held in Europe for the first time: 10-15 Aug25 Barcelona, Spain. Please repost and apply early - this meeting is popular! www.grc.org/epigenetics-...

Want to learn more about cell extrusion? What causes it and why is it essential? Check out this fantastic thread by our student @zoya-mann.bsky.social elaborating on the epithelial mechanics of cell extrusion!👇
Follow @epimechfc.bsky.social for more such cool threads..

Cell and Tissue Dynamics (Wickström)

My lab at the Max Planck Institute for Molecular Biomedicine in Muenster, Germany offers postdoc positions in stem cell mechanobiology. www.mpi-muenster.mpg.de/departments/... drop me an email

Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development.
Details below 👇👇
Please Repost !!!

@ijmonod.bsky.social @cnrs.bsky.social

Roffay, C., Chan, C. J., Guirao, B., Hiiragi, T., & Graner, F. (2021). Inferring cell junction tension and pressure from cell geometry. Development (Cambridge, England), 148(18), dev192773. #EpithelialMechanicsReview

journals.biologists.com/dev/article/...

Check this out!👇
Our new work reveals anilin’s putative role in mediating actomyosin remodeling and membrane composition

Two post-doctoral positions to study the mechanisms of epithelial homeostasis are available in the laboratory of Professor Alpha Yap @yap-lab.bsky.social (Institute for Molecular Bioscience, IMB, University of Queensland).
focalplane.biologists.com/cell-biology...

🚨Postdoc vacancy alert!

Interested to work on apoptosis/inflammation? Have some experience in biosensor-imaging and quantitative analysis of dynamic systems?

2 positions available for 2 years with potential of extension
Apply now! 👉
uq.wd3.myworkdayjobs.com/uqcareers/jo...

Looking for a tool to analyse cell / tissue orientation on surfaces of 3D systems?

Check out this extremely user friendly tool generated by @juliaeckert.bsky.social in her new preprint👇

🚨Postdoc vacancy alert!

Interested to work on apoptosis/inflammation? Have some experience in biosensor-imaging and quantitative analysis of dynamic systems?

2 positions available for 2 years with potential of extension
Apply now! 👉
uq.wd3.myworkdayjobs.com/uqcareers/jo...

Thrilled to share our new preprint on detecting the nematic orientation field on surfaces of 3D multicellular systems!

www.biorxiv.org/content/10.1...

Huge thanks to all authors: @tobyandrews.bsky.social,Joe Pollard, @rashmi-priya.bsky.social, @yap-lab.bsky.social &Richard Morris

Any 3D systems?👇