Prof Deepak Modi

Elated on the publication of my book chapter on spermatogenesis in the prestigious book on Assisted Reproduction by Dr Gautam Allahabadia
Big shout out to my co author Indrashsis

2 new studies from the lab show that early pregnancy needs inflammation but only briefly. When uterine inflammation does not activate in time, implantation fails and if prolongs pregnancy is lost.
Links
doi.org/10.1093/reprod…
doi.org/10.1016/j.lfs.���
Super proud of my team

Republic Day Greetings

The IBEX KB provides several ways to contribute and use data.

The IBEX Knowledge-Base is setting a new standard for reproducibility in #immunofluorescence imaging: open, community-driven, and with ‘exceptional’ evidence of its utility.

It’s now up to the community to contribute to its growth.

🔗 buff.ly/klv0TSF

Common variation in meiosis genes shapes human recombination and aneuploidy - Nature Analysis of data from pre-implantation genetic testing sheds light on the genetic basis of meiotic-origin aneuploidy, the leading cause of human pregnancy loss, identifying common genetic variants ass...

Regulation of embryonic ploidy by meiotic recombination.. expected ? Unexpected?
www.nature.com/articles/s41...

WHO statement on notification of withdrawal of the United States WHO regrets the United States’ notification of withdrawal from WHO – a decision that makes both the United States and the world less safe. The notification of withdrawal raises issues that will be con...

WHO statement on notification of withdrawal of the United States share.google/nfdhuCJAQrzW...

Loss of HOXA10 activates NLRP3 for epithelial plasticity and pyroptosis in endometrium during embryo implantation In briefA successful pregnancy begins with embryo implantation, but how the embryo breaks through the endometrial lining is not understood. Here, we uncove

Elated to share the publication of our paper on how HOXA10 controls NLRP3 to drive #hybridEMT and pyroptosis for embryo implantation
#Inflamation #pregnancy #reproduction

academic.oup.com/reproduction...

Genome Shows no Recent Inbreeding in Near-Extinction Woolly Rhinoceros Sample Found in Ancient Wolf's Stomach Using temporarily spaced high-coverage ancient genomes, we can assess population decline prior to extinction. However, finding suitable ancient remains for recovering this type of data is challenging. Here, we sequenced a high-coverage genome from ...

Woolly Rhino was not experiencing population decline prior to its rapid extinction ~14,000 years ago, based on DNA recovered from mummified wolf stomach in Siberian permafrost. Instead, extinction likely due to rapid environmental change.

🧪🌎🧬🖥️ #EvoSky #Genomics

pmc.ncbi.nlm.nih.gov/articles/PMC...

Tylenol during pregnancy is safe without increased risk of autism, ADHD, or intellectual disability of offspring
A new review of the evidence just out
www.thelancet.com/journals/lan...

The serenity of the city called Bhubaneswar

Biophysics of organoids In this review, Weichselberger, Moore et al. discuss how physics-based approaches illuminate organoid development and homeostasis by integrating mechanical, chemical, and informational processes. They...

Interested in the biophysics of organoids? We just published a review in Dev Cell—take a look! dlvr.it/TPyTb8 #Organoids #Biophysics

All-in-one Single-Cell Proteomic Analysis of Protein Alterations in Human Oocytes Undergoing in Vitro Aging https://www.biorxiv.org/content/10.64898/2026.01.05.697813v1

Indias position statement on the use of niPGT for clincial use is published in JHRS and covered by the media
#ivf #fertilityclinic
#embryo
#genetics
www.ndtv.com/health/india...

Temporal control of decidual inflammation by HOXA10 is essential for implantation and its dysregulation is associated with early pregnancy loss Successful implantation requires tightly regulated endometrial inflammation. While initial inflammatory signaling is essential for implantation, persi…

The year 2026 opens with a bang
Thrilled to share the publication from the lab showing that an inflammation is essential for embryo implantation
#fertility #miscarriage #uterus #infertility

www.sciencedirect.com/science/arti...

The year closes with a key policy paper.
India issues its position statement on non-invasive PGT (niPGT). Based on available data of 3000 embryos an expert review panel concludes that niPGT is not ready for clinical use for embryo selection.

journals.lww.com/jhrs/fulltex...

Exclusive: the most-cited papers of the twenty-first century A Nature analysis reveals the 25 highest-cited papers published this century and explores why they are breaking records.

Techniques, methods papers and software papers are bound to be higher on scoreboards and there are no prizes for guessing that. For which direction the science is moving .. ideal would be to look at highly cited original papers and look at field normalised citations.
www.nature.com/articles/d41...

The sun kissed evening.
Chasing the sun across the horizon. Watching the world trade its gold for midnight sapphire at 30,000 feet. There’s a certain kind of magic between sun, clouds and the sky.
​#WindowSeatViews
#DuskTillDawn
#SkyAesthetic
#GoldenHourMagic
#HorizonLines

Fantastic insights on how replication stress drives cell differentiation by Osvaldo Contreras at the joint meeting of the #InSDB and International Society of Differentiation #ISD joint meeting at #IISER_BERHAMPUR
@osvaldoics.bsky.social
#INSDBISD2025

This is just is just the tip of the iceberg ... Much more mess is around

The much awaited joint meeting of Indian Society of Developmental Biologiy #InSDB and International Society of Differentiation #ISD and has begun and excited to be a part of it. I will be taking on Wednesday Dec 17 2025 about our work on embryo implantation

Elected at the executive council of Society for Reproductive Biology and Comparative Endocrinology #SRBCE
Looking forward to ser6ve the society and taking Indian science to the international map

Deciphering mechanisms leading to preterm birth through post-GWAS integration of multi-omics data Clinical genetics; women's health; omics

www.cell.com/iscience/ful...

Batch 1 and batch 2 to off to IISER Bherampur for the coveted and much awaited meeting of the Indian Society of Developmental Biologist #InSDB 2025
Excited to present our groups work on embryo implantation and placental organ on chip and placentoids models

Some beautiful insights into the genomics of #Preterm births. Key SNPs in the maternal genome are strongly associated with Preterm delivery in the Indian population. Dr Arindam Mitra BRIC-NIBMG at #ReproNext2025 #SRBCE2025 #prematurity

A phenomenal keynote address by #padmashree Dr Neerja Bhatla on cervical cancer screening and prevention at the #ReproNext2025 and 42nd annual meeting of #SRBCEn2025

The inauguration of ReproNext 2025 begins
It's also the 42nd annual meeting of SRBCE
#ReproNext2025 #SRBCE2025

@devoevomed.bsky.social
This might be of interest to you

HOXA10 is a Temporal Switch in Controlling Decidual Inflammation and Its Dysregulation is Associated with Early Pregnancy Loss Successful implantation requires precisely timed endometrial inflammation. Although an initial inflammatory burst is essential for implantation, this response must be rapidly resolved for placentation...

Hot from the lab
Our #preprint describing how #inflammation is controlled at #embryo implantation and it's defect leads to placental dysregulation and #miscarriage
www.biorxiv.org/content/10.6...

We need to make a framework for both preclinical and clinical testing of drugs in pregnancy

Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl The molecular, cellular, and functional restoration of the axolotl thymus after de novo regeneration is described.

Can't believe my postdoc paper is finally out. Christmas came early this year, holy moly 🎄

Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl | Science Immunology www.science.org/doi/10.1126/...