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Brian Fisher

@fishparade.bsky.social

Enzyme tinkerer, FFIX stan, 10-year ReadCube subscriber

350 Followers  |  394 Following  |  242 Posts  |  Joined: 24.08.2023  |  2.1286

Latest posts by fishparade.bsky.social on Bluesky

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4 x 4L bottle boxes are the GOAT of moving

21.10.2025 15:02 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Sleeeiiiigh

07.10.2025 00:51 β€” πŸ‘ 103    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

For Texas residents offended by this, ask yourself: What kind of person wants to move to Texas? Not people who want to move to be closer to family or whateverβ€”people who believe in their hearts that Texas is where they were meant to be?

06.10.2025 12:11 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Site-, Stereo-, and Chemoselective Enzymatic Halogenation of Terpenoids by a Substrate Masquerade Enzymatic halogenation of C–H bonds is a promising approach to synthesize chlorine-containing compounds. However, few halogenases chlorinate C(sp3)–H bonds of molecules lacking a carrier protein, and ...

This is such a neat idea from the @narayanlab.bsky.social and the @hartwiggroup.bsky.social now in #JACSasap fooling enzymes with a removable binding ligand to accept non-native substrates #ChemSky

27.09.2025 18:24 β€” πŸ‘ 18    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0

Universal Basic Jackass

25.09.2025 20:03 β€” πŸ‘ 10    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Tylenol’s gotta be in blister packs

22.09.2025 13:01 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Larry Tesler, inventor of the cut, copy, and paste commands, dies at 74

16.09.2025 01:07 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

The thing I love about taxonomy is that it never changes and everyone agrees on names for everything!!!

11.09.2025 18:03 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Wish I owned the copyright to all the papers of mine used by them…

06.09.2025 11:46 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Stirring Bars are Superstition?

Do you really need to stir your reactions? How do you know?

04.09.2025 19:39 β€” πŸ‘ 59    πŸ” 11    πŸ’¬ 17    πŸ“Œ 9

"oh nothing matters because mr. trump won't let it matter" shut up

31.08.2025 13:26 β€” πŸ‘ 2519    πŸ” 188    πŸ’¬ 12    πŸ“Œ 11

I know in France the equivalent is β€œBrian is in the kitchen”. A French former coworker was amused to learn my name.

30.08.2025 23:58 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Getting into homeownership is really making me much more of a just-call-customer-service person than I expected

29.08.2025 22:38 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

A lot of people will believe this shit! Lots of suburban and rural folks truly think that US cities are literal war zones. They could easily be convinced that if they visit them and find them pleasant and safe that it was all Trump’s doing rather than them being fine the whole time.

25.08.2025 17:18 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

ACS 1996 is a fine starting point but imo you should probably manually tailor your ChemDraw object settings to whatever kinds of molecules you work most with. I worked with polypeptides through my PhD and I really didn’t like how its skinny bonds made these long molecules look like chicken scratches

10.08.2025 00:50 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Oh so it does have phd level intelligence

08.08.2025 08:42 β€” πŸ‘ 2865    πŸ” 571    πŸ’¬ 57    πŸ“Œ 15

Trump take video game

01.08.2025 14:00 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Hope the estate of Henrietta Lacks is on this

31.07.2025 13:21 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Hopefully it stays that way longer than the 2-ish hour runtime of this experiment!

31.07.2025 00:41 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Baby’s first Nanopore run

30.07.2025 15:28 β€” πŸ‘ 6    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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Embattled 'arsenic life' paper retracted by journal Science 15 years after publication A controversial 2010 study that suggested bacteria could grow using arsenic instead of phosphorus has been retracted by the research journal Science.

The 2010 paper claiming arsenic-based life has been retracted by Science today. πŸ§ͺ

24.07.2025 18:05 β€” πŸ‘ 81    πŸ” 32    πŸ’¬ 5    πŸ“Œ 11
23.07.2025 20:25 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Follow @wario64.bsky.social and repost for a chance to win 1 of 15 Steam codes for Dungeons & Dragons Neverwinter Nights 2: Enhanced Edition courtesy of @aspyr.com. Giveaway ends on July 20th, 6 PM PT

game is available now on PC and consoles store.steampowered.com/app/2738630/...

16.07.2025 19:44 β€” πŸ‘ 571    πŸ” 885    πŸ’¬ 23    πŸ“Œ 4

Pedagogy is often worse at more elite institutions, even. Place like Indiana University have faculty that publish in J Chem Ed. More elite institutions just wanna hire more faculty who’ll publish in CNS, their teaching skills be damned.

17.07.2025 12:29 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 1

And his nephew was the landlord of some of my friendsβ€”deep ties!

02.07.2025 19:02 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Also, if AI tools were any good at making highly-targeted completely novel molecules, it’d be a lot better at making the therapeutic ones than it is

01.07.2025 19:45 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

As a chemist, this sort of thing doesn’t really worry me. A non-chemist would need more than ChatGPT to start synthesizing any chemical weapon. Anyone with the skills to make a chemical weapon can already make known ones, and new ones could be made by trivial modifications around a reactive group

01.07.2025 19:45 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Mine was β€œyou’re an uncultured slob for having a shellfish allergy”

29.06.2025 22:10 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Something anybody who’s set up parallel heterogeneous catalysis experimentsβ€”or reactions limited by gas transfer ratesβ€”has probably run into at some point. Good to see this phenomenon highlighted!

20.06.2025 15:57 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Even worse is cafes that make their own oat milk. Oatly is good, just buy that! The only two lattes I’ve ever tossed because they were so bad had homemade oat milk.

16.06.2025 19:12 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

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