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James Gurney

@jamesgurney.bsky.social

Assistant professor working on phage. Occasional writer/fact checker for kurzgesagt. I didn’t write dinotopia.

1,533 Followers  |  523 Following  |  176 Posts  |  Joined: 11.09.2023  |  2.0676

Latest posts by jamesgurney.bsky.social on Bluesky

Trust Us, we're Liars -Pilot Podcast
YouTube video by The League of Nerds Trust Us, we're Liars -Pilot Podcast

A few months ago, myself @sallylepage.bsky.social and @dhewlett.bsky.social sat down and recorded a pilot podcast for Kurzgesagt interviewing Cancer expert @kimberly-luddy.bsky.social about all things Cancer. While the project is no more, I thought I'd share it! youtu.be/ZXo6uTf3Im8

21.10.2025 02:44 — 👍 2    🔁 0    💬 0    📌 0
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Household energy after submitting grant this week.

05.10.2025 00:36 — 👍 4    🔁 0    💬 0    📌 0
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Underpinning Bioscience - Paul A Hoskisson

Come and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production

Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces

www.gla.ac.uk/postgraduate...

please repost

30.09.2025 11:02 — 👍 35    🔁 56    💬 0    📌 3
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PhD fellowship in biofilm-phage interactions

PhD fellowship in biofilm-phage interactions - with Mette Burmølle at University of Copenhagen 🇩🇰
deadline 1 October 2025

employment.ku.dk/faculty?show...

#phagesky #microsky

28.09.2025 14:26 — 👍 8    🔁 8    💬 1    📌 0

Come join us in Knoxville! 🧫🧪🦠

17.09.2025 20:00 — 👍 10    🔁 10    💬 0    📌 0
Bacteria–phage infection network structure and genomic defence system content predict efficacy of a phage therapy cocktail against Pseudomonas aeruginosa from chronic lung infections

Recent paper from the lab studying predictors of phage cocktail efficacy against complex clinical Pseudomonas populations

royalsocietypublishing.org/doi/epdf/10....

Led by Rosanna Wright with extraordinary MSc (PhD) student Maisie Czernuska

25.09.2025 13:55 — 👍 26    🔁 16    💬 2    📌 0
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Better together: Reciprocal activation of quorum sensing circuits enhances bacterial communication Many bacteria use quorum sensing to control gene transcription based on population density. This primer explores a recent study in PLOS Biology which found that in Pseudomonas aeruginosa, two quorum-s...

Andrew Frando, @jrchandler.bsky.social, and I wrote a primer about excellent work done in Sam Brown's group @brownlab.bsky.social

journals.plos.org/plosbiology/...

06.09.2025 21:08 — 👍 7    🔁 3    💬 1    📌 1
The las and rhl QS systems have a reciprocal, synergistic, and unequal relationship. Top: Single-signal models demonstrate that the summed effects of single signals (3 oxo C12 HSL alone, red; C4 HSL alone, orange) cannot account for the maximal expression of lasI or rhlI. The upper green, flat surfaces in the plots indicate the maximum mean expression level measured across all combinations of signal concentrations while the lower semi-transparent surfaces mark the sum of single signal effects. The plotted points represent observed expression levels when C4 HSL is withheld (red) and when 3 oxo C12 HSL is withheld (yellow). Lines indicate the model predictions. Bottom: Multi-signal non-linear models capture the synergistic effects of both signals and match observed expression levels. Model estimates are shown as grid lines. Horizontal bars show the mean value of expression observed at each combination of signal concentrations. Lines extend from these mean values to the relevant grid point for clarity. Right: Data show that relationship of the las and rhl systems is reciprocal, and the multi-signal model quantifies the strength of those interactions. In particular, it reveals the contribution of both signals to the maximum fold-change in expression of both synthases. The charts in this panel summarize the contribution of 3 oxo C12 HSL (red), C4 HSL (yellow), and the synergistic combination of both (orange).

The las and rhl QS systems have a reciprocal, synergistic, and unequal relationship. Top: Single-signal models demonstrate that the summed effects of single signals (3 oxo C12 HSL alone, red; C4 HSL alone, orange) cannot account for the maximal expression of lasI or rhlI. The upper green, flat surfaces in the plots indicate the maximum mean expression level measured across all combinations of signal concentrations while the lower semi-transparent surfaces mark the sum of single signal effects. The plotted points represent observed expression levels when C4 HSL is withheld (red) and when 3 oxo C12 HSL is withheld (yellow). Lines indicate the model predictions. Bottom: Multi-signal non-linear models capture the synergistic effects of both signals and match observed expression levels. Model estimates are shown as grid lines. Horizontal bars show the mean value of expression observed at each combination of signal concentrations. Lines extend from these mean values to the relevant grid point for clarity. Right: Data show that relationship of the las and rhl systems is reciprocal, and the multi-signal model quantifies the strength of those interactions. In particular, it reveals the contribution of both signals to the maximum fold-change in expression of both synthases. The charts in this panel summarize the contribution of 3 oxo C12 HSL (red), C4 HSL (yellow), and the synergistic combination of both (orange).

Bacterial #QuorumSensing is often assumed to follow a strict hierarchy. @brownlab.bsky.social &co find that #Pseudomonas aeruginosa instead uses a reciprocal, cooperative system that enhances responsiveness to population density & environmental changes @plosbiology.org 🧪 plos.io/3I7DhRG

05.09.2025 13:36 — 👍 19    🔁 10    💬 2    📌 0
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Standing room only for Eli Mehlferber from @brownbio.bsky.social for breakfast talk this morning. Giving a great talk.

05.09.2025 12:41 — 👍 0    🔁 0    💬 0    📌 0
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queen elizabeth is wearing a blue suit and pearls . ALT: queen elizabeth is wearing a blue suit and pearls .
03.09.2025 19:42 — 👍 1    🔁 0    💬 0    📌 0
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a man is sitting at a desk with a panda bear on his shoulders ALT: a man is sitting at a desk with a panda bear on his shoulders
03.09.2025 19:41 — 👍 0    🔁 0    💬 0    📌 0
BBC News has become subscription based

BBC News has become subscription based

WHAT?!? one way to cut off my last connection to the UK. Since when has the BBC News become subscription based?

03.09.2025 19:30 — 👍 3    🔁 0    💬 3    📌 0
Electron micrograph of two phage infecting a host cell side-by-side, with hearts between them

Electron micrograph of two phage infecting a host cell side-by-side, with hearts between them

Do you love phage? I have an opening for a postdoc in my lab at the University of South Florida College of Marine Science (@cmarinescience.bsky.social) looking at interactions between marine phage and iron, which is an important limiting trace metal in the oceans (1/5) 🧵#phagesky 🦠🌊

01.08.2025 13:45 — 👍 79    🔁 68    💬 3    📌 1
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~3 inch Joro Spider. Invasive species in Georgia now.

17.08.2025 23:18 — 👍 2    🔁 0    💬 0    📌 0
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New foster in the house. “Lovely” she fits her name to a tee. If you know anyone looking for a dog in the Atlanta area hit me up!

16.08.2025 22:04 — 👍 2    🔁 0    💬 0    📌 0
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This is what the look of betrayal from a cat looks like.

16.08.2025 17:50 — 👍 4    🔁 0    💬 0    📌 0
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Research position in Microbial Pharmacology and Population Biology (282139) | UiT The Arctic University of Norway Job title: Research position in Microbial Pharmacology and Population Biology (282139), Employer: UiT The Arctic University of Norway, Deadline: Wednesday, August 27, 2025

Feels surreal to say but: I'm hiring! If you are or know anyone interested in looking at the evolution of phage resistance using A. baumannii and natural transformation, then this might be for you
www.jobbnorge.no/en/available...

08.08.2025 07:52 — 👍 69    🔁 66    💬 1    📌 4
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Very proud of my three wonderful Summer undergrad research fellows, all supported by the Molecular Basis for Disease program at State. All three have done great work and have been a pleasure to have in the lab.

07.08.2025 20:24 — 👍 9    🔁 0    💬 1    📌 0

I'd love to come. We have two projects that are ready for public consumption. CRISPRcas and salt. we combined bioinformatics and wet work to explain why archaea have a higher prevalence of Cas. 2nd single cell RNA seq under phage infection. Also happy to talk about outreach and work with Kurzgesagt.

31.07.2025 14:20 — 👍 2    🔁 0    💬 0    📌 0
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Finally got my iPod touch to turn back on. I bought this with my first PhD pay check. Time to listen to some classic pre 2010 tunes.

28.07.2025 15:15 — 👍 4    🔁 0    💬 0    📌 0

That climb yesterday was something else.

18.07.2025 16:15 — 👍 1    🔁 0    💬 0    📌 0
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Used AI to recreate the strangest bathroom I viewed when I was trying to find an apartment in France. This is a fairly close rendering. Including the off angle steps and it being in the center of the room. It was a bizarre death trap. Just the right height if you fell you’d break your neck.

18.07.2025 00:00 — 👍 2    🔁 0    💬 0    📌 0
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New lab logo

12.07.2025 19:36 — 👍 32    🔁 4    💬 1    📌 1
College of New Hampshire views and people eating lobster

College of New Hampshire views and people eating lobster

Lovely time with new and old friends at microbiology population biology camp. Leaving with lots of new ideas (and lots of new bug bites)

@cbibberson.bsky.social @peachypotato.bsky.social @jamesgurney.bsky.social

11.07.2025 15:43 — 👍 17    🔁 3    💬 2    📌 0
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Feeling tired but inspired after a great week at the #MicrobialPopBioGRC. Great to see old friends and make some new ones! 🦞🗻🧫

@ginalewin.bsky.social @peachypotato.bsky.social @jamesgurney.bsky.social @stephenkdolan.bsky.social

11.07.2025 16:52 — 👍 13    🔁 1    💬 1    📌 0
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My first GRC and I get why this is so many folks favorite meeting. Great presentations and interaction with some many people.

Only gripe is my room was hot. But it also does this! Warning flashing lights!

10.07.2025 13:56 — 👍 4    🔁 0    💬 2    📌 0

I’m sure the are at least 4 and 20 good reasons for this choice.

09.07.2025 11:24 — 👍 1    🔁 0    💬 0    📌 0
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PhD Project: Discovering Novel Mechanisms of Phage Genome Evolution We are looking for an awesome PhD student to join our research team to investigate how bacteriophages (phages) generate targeted mutations that enable them to evolve and infect new bacterial hosts. Yo...

PhD opportunities at @flindersuniversity.bsky.social in Adelaide, Australia's most liveable city, to study genetics in #phage

We will also have genetics #postdoc positions too!

#microsky #phagesky

www.linkedin.com/pulse/phd-pr...

07.07.2025 08:23 — 👍 15    🔁 19    💬 0    📌 1
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Nice place to hangout for a week and hear some cool science.

07.07.2025 11:21 — 👍 6    🔁 0    💬 1    📌 0

Looking forward to seeing everyone, new and old, at the Microbial Population Biology GRS + GRC in just a couple days!

go.bsky.app/GGxRjzC

03.07.2025 20:25 — 👍 72    🔁 28    💬 13    📌 8

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