Sigolène Meilhac

We uncover that the caudal splanchnic mesoderm (in green) acts as a midline anchor of the heart tube. In Vangl2 and Shroom3 mutants, its bilateral symmetry is disrupted, leading to a rotation of the heart tube and ventricle malposition.

In the dorsal pericardial wall, Vangl2 localises at multicellular junctions and is required for their resolution. This promotes cell rearrangements underlying elongation of the arterial pole of the heart tube.

Paul Palmquist-Gomes, in collaboration with @gaellel.bsky.social, quantified the phenotype of a series of mutants to show that Vangl2 is required in two epithelia adjacent to the heart tube.

New publication :
Despite being a core member of the PCP pathway, Vangl2 can play roles unrelated to planar polarity. This is the case during mouse heart morphogenesis.

She analysed a mouse model of motile ciliopathy to show that the node can be dispensable to establish left-right asymmetry. Stay tuned !

Congratulations Dr Amaia Ochandorena-Saa for a beautiful PhD, defended in front of Hiroshi Hamada, @bakkerslab.bsky.social, Alice Meunier and Jeanne Amiel

Abnormal D-LOOP are also observed in patients and tend to be associated with poorer prognosis. We reconstruct their developmental revertant trajectory in the mouse. Team work in collaboration with JB Masson and O Raisky.

@audreydsg.bsky.social performed a unique longitudinal analysis of heterotaxy by imaging the same mouse twice, at E9.5 and E18.5. We show that embryonic heart loop shape is a partial predictor of CHD.

We report how ventricle can still change position after heart looping in Nodal mutants, questioning the clinical nomenclature of « D-LOOP ». D-LOOP ventricles at birth can arise from both rightward or leftward embryonic heart looping.

Plasticity of ventricle position after heart looping in heterotaxy with right isomerism The left/right position of ventricles needs to be maintained after heart looping, an unexpected step affected in heterotaxy.

New publication | Science Advances www.science.org/doi/10.1126/...

In collaboration with MP Hitz, we identify 6 ultrarare NOTCH3 variants in a cohort of patients with congenital heart defects, reflecting the double role of Notch3 in laterality and heart development

We also show that Notch3 is expressed in the second heart field and required for ventricular and atrial septation, right ventricle wall thickness and the non coronary leaflet of the aortic valve

We identified Notch3 as a new asymmetric gene, amplified by Nodal and a genetic modifier of heart looping defects in Nodal mutants

New article of the lab on Notch3, not only involved in vascular or neural defects, but also in heart defects and laterality defects.

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The Weinstein Committee is soliciting nominations for the 2025 Markwald Award. If you have a scientist you'd like to nominate send it to mpatterson@mcw.edu by February 7th!

Join us for the 2025 Weinstein Cardiovascular Development and Regeneration Conference in Milwaukee, May 14-16! Registration and abstract submission are now open!!! Please share, retweet, and distribute! #WeinsteinCVD2025 REGISTER TODAY HERE childrenswi.org/weinstein

We are opening a call for applications 2025 – Creation of new junior research groups at the Institut Pasteur in Paris @pasteur.fr all details on our web site : research.pasteur.fr/en/call/call...

Abstract submission is now open for the 2025 Weinstein Cardiovascular Development and Regeneration Conference at childrenswi.org/weinstein. The conference will be held in Milwaukee, May 14-16! Please share, retweet and distribute ❣️❣️❣️#WeinsteinCVD2025

Yes! We are hiring! Looking for highly motivated people to make good use of our #ERC_SyG money 💶! The project is super cool, and the people are the best!! There are plenty of opportunities for international collaborations, too! Please help us spread the word!

Is Nodal the only determinant of left-right asymmetry? 🤔 If curious and willing to address the question with lab resources in transcriptomics, mouse genetics and quantitative 3D imaging, please contact me.

We hire ! Open #postdoc position to study the emergence of heart asymmetry in Paris !
#devbio

For the dev bio crowd : there is a call for junior group leader at Institut Pasteur in Paris and one of the axis covered is related to development. Come and join us in this exciting place and become one of our colleague @devstempasteur.bsky.social
Please RT !!
research.pasteur.fr/fr/call/call...

🚨🚨🚨 Not one, but 3 calls for junior group leaders opening at Imagine!!! [please share]
- Systems and computational biology
- RNA biology and epigenomics
- AI for genetics, biology and medicine
Come and join us!
www.nature.com/naturecareer...