club CFC

Detail from the graphical abstract: mouse with deletion of the gene Glis2, Glis2 interaction network and the link to DNA damage. Generated with biorender.com.

Fresh online: our paper on Glis2 - project started years ago, and it’s finally out! Congratulations and a big thank you to Lena, Gisela, and the whole team!
tinyurl.com/Glis2

#Cilia #nephrology #ciliopathy
#DDR #nephrolab @ajpseditor.bsky.social @uniklinikkoeln.bsky.social @cecad.bsky.social

Primary #cilia dysfunction as in Bardet-Biedl syndrome compromises normal adipogenic differentiation in favor of fibrogenic transition, predisposing to obesity
@wachtenlab.bsky.social and collaborators
www.embopress.org/doi/full/10....

The Neuronal Primary Cilium is a Key Regulator of Homeostatic Plasticity The capacity of neurons to maintain stable activity levels through homeostatic plasticity is essential for proper brain function. Primary cilia, which are non-motile, antenna-like organelles projectin...

New #cilia preprint alert

Our latest manuscript is now live on bioRxiv:
"The Neuronal Primary Cilium is a Key Regulator of Homeostatic Plasticity"

We hope you enjoy reading it!

www.biorxiv.org/content/10.1...

Spotlight: Yameng Huang and Cynthia He discuss recent advances from Araujo Alves et al. @bastinlab.bsky.social (rupress.org/jcb/article/...), describing how intraflagellar transport trains in T. brucei selectively associate with axonemal doublet #microtubules. rupress.org/jcb/article/...

#Cilia

How do trypanosome IFT trains choose special tracks? Yameng Huang and Cynthia He (National University of Singapore) discuss recent advances from @bastinlab.bsky.social (rupress.org/jcb/article/...), in Spotlight: rupress.org/jcb/article/...

#Biochemistry #Organelles #Cilia #Flagella #Trypanosomes

So proud and happy to share that our study on the #proteome, heterogeneity, and cell-type specificity of primary #cilia is published now at Cell 🎉

Big thank you to all the many people that made this possible, at the Lundberg Lab, Human Protein Atlas, Lindstrand lab, and Hsien-Sheu lab.

We have something for everyone- CSF flow & #neurodegeneration, ciliary trafficking of PKD2 complexes, cilia & #actin dynamics, #DNADamageResponse & multiciliation, cilia & pituitary development & transcriptional control of ciliogenesis... Great breaking science & rising talent to be showcased...🧪

Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️

➡️ www.nature.com/articles/s41...

Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆

Save the date!
March 2027 on beautiful lake Maggiore right outside #Milan, are you ready for #Cilia2027? 🥳
Stay tuned for more info!

GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration Primary cilium senses mechanical cues to regulate young neuron migration via GPR161 signaling.

🎉Excited to see my master’s work contributed to this amazing paper! 🎥 🧠

Congrats to all co-authors 👏
Grateful for my time in Dr. Isabelle Caillé & Pr. Alain Trembleau’s lab #IBPS. Isabelle’s passion for science will keep inspiring me ✨

doi.org/10.1126/scia...

#Trypanosoma, fixed, expanded, and imaged with #STED, stained for tubulin. Scale bar refers to expanded specimen, original structures are 3-3x smaller.
Image courtesy: @mbonhivers.bsky.social, MFP, CNRS, Univ. Bordeaux, France
#fluorescencefriday #ExM #STEDmicroscopy

Structure-Activity Analysis Reveals Perturbed Cilia-Jun N-Terminal Kinase Signaling in MAPKBP1-Associated Kidney Disease Nephronophthisis (NPH) is a renal ciliopathy characterized by chronic tubulointerstitial fibrosis. Despite discovery of multiple disease genes, mechanisms of NPH-associated kidney degeneration remain ...

New interesting paper on MAPKBP1, which sheds new light on its localization and function at #cilia! Many thanks to Ria and Jan for inviting us to participate in this exciting work! Congratulations to all collaborators!
#ciliopathies #kidney #nephronophthisis

www.kireports.org/article/S246...

Daniel's paper is now published in @jcellsci.bsky.social, great experience with @reviewcommons.org 😀

Want to know everything tubulin assembly in trypanosome flagella and other microtubules? Here is the link:

journals.biologists.com/jcs/article/...

Ciliated teddy bear!

Prostaglandin Analogs and Eupatilin as Treatments for Nephronophthisis Primary cilia are sensory antennas that are present on the majority of quiescent vertebrate cells where they mediate key signaling during development …

Our last paper is now available on the Kidney International website! Thanks to all collaborators and special congrats to Alice and Guillaume... #cilia #ciliopathies #kidney

www.sciencedirect.com/science/arti...

📣 Don’t miss the review by @bolettalab.bsky.social & S. Clerici on metabolic and mitochondrial alterations in #PolycysticKidneyDisease and other renal #ciliopathies ➡️ doi.org/10.1038/s443...

at IRCCS San Raffaele Scientific Institute

Convergence and consensus In these days of political instability, geopolitical tensions, and social discontent around the world, there are continued threats to the principles, conduct, and findings of science. This assault on ...

www.science.org/doi/10.1126/...

Intraflagellar transport trains can switch rails and move along multiple microtubules in intact primary cilia | PNAS Structural homeostasis and proper distributions of signaling molecules in cilia require a constant flow of cargoes carried by intraflagellar transp...

IFT trains in primary #cilia

Intraflagellar transport trains can switch rails and move along multiple microtubules in intact primary cilia | PNAS www.pnas.org/doi/10.1073/...

Cilia-AI

9 PhD positions to work on #cilia and #ciliopathies including 2 in our lab @hkd-l.bsky.social @institutimagine.bsky.social

www.cilia-ai.eu

Dear cilia researchers, join us in the heart of the beautiful Vosges mountains to share your latest findings! This year, partnership with @for5547.bsky.social and keynote lectures by @micromotility.bsky.social and @mick-lab.bsky.social
Registration is now open www.cfc2025.conferences-pasteur.org

📣Thrilled to announce that the registration for the 8th annual Czech #Cilia #Meeting (17 June 2025, #Brno) is NOW OPEN:

🪧https://forms.gle/wkooViZtBGxvVASNA

👩‍🔬INVITED SPEAKER: Ruxandra Bachmann-Gagescu

⏱️Registration deadline: 17 May 2025

Meeting Cils, Flagelles et Centrosomes à 67-Oberbronn Cette année, le meeting Cils, Flagelles et Centrosomes aura lieu du 13 au 15 octobre. This year, the Cilia, Flagella and Centrosome Meeting will take place from October 13th to 15th.

First announcement for the 2025 meeting of the #cilia, #flagella and #centrosome club which will be held from October 13 to 15, in Oberbronn, Alsace, eastern France.

gmgm.unistra.fr/en/news/meet...

Meeting Cils, Flagelles et Centrosomes à 67-Oberbronn Cette année, le meeting Cils, Flagelles et Centrosomes aura lieu du 13 au 15 octobre. This year, the Cilia, Flagella and Centrosome Meeting will take place from October 13th to 15th.

First announcement for the 2025 meeting of the #cilia, #flagella and #centrosome club which will be held from October 13 to 15, in Oberbronn, Alsace, eastern France.

gmgm.unistra.fr/en/news/meet...

Complete loss of IFT27 function leads to a phenotypic spectrum of fetal lethal ciliopathy associated with altered ciliogenesis - European Journal of Human Genetics European Journal of Human Genetics - Complete loss of IFT27 function leads to a phenotypic spectrum of fetal lethal ciliopathy associated with altered ciliogenesis

Here is a recent paper by colleagues from @hopitalnecker.bsky.social and @institutimagine.bsky.social showing that loss of IFT27 lead to fetal #ciliopathies with #cilia defects in #kidney

www.nature.com/articles/s41...

Chemical inhibition of Exon Junction Complex assembly impairs mRNA localization and neural stem cells ciliogenesis The Exon Junction Complex (EJC) is formed by the essential eIF4A3, MAGOH and Y14 core proteins. It is universally deposited during splicing at exon-exon junctions. The EJC is known to impact almost ev...

Interesting preprint by the group of Hervé le Hir showing that inhibition of the Exon Junction Complex (EJC) which is found at the basal body perturbed primary #cilia biogenesis in neural stem cells.

www.biorxiv.org/content/10.1...

Actin-based deformations of the nucleus control mouse multiciliated ependymal cell differentiation Ependymal cells (ECs) are multiciliated cells in the brain that contribute to cerebrospinal fluid flow. ECs are specified during embryonic stages but …

New great paper in Developemental Cell by Nathalie Delgehyr and collaborators in Nathalie Spassky's lab on the action of actin-based cytoskeleton on the the nucleus in multiciliated cell differentiation. #cilia

www.sciencedirect.com/science/arti...

Two recent great papers in Cell Reports from Alice Meunier on how cell cycle regulates #cilia biogenesis and multiciliated cell differentiation.

Maitre de conférence-Université de Rouen Normandie_Sections 65 et 69 Neuroendocrine EndOcrine and GeRminal DIfferentiation and Communication -Plasticité et Physiopathologie Neuroendocrine

exoendo.org/offre-demplo...

Last few days to submit your research on #cilia and #flagella to our upcoming special issue, coordinated by Guest Editors Pleasantine Mill @cilialab.bsky.social and Lotte Pedersen @lottepedersen.bsky.social.
journals.biologists.com/jcs/pages/ci...

March #ImageOfTheMonth goes to M.Bonhivers from MFP lab (UMR 5234).
Trypanosoma brucei cell was extracted in detergent, expanded 4.2 fold using U-ExM, labelled for the microtubule cytoskeleton (magenta) and for the Hook Complex (yellow), and images usinf scanning confocal microscopy.