Ruben van Helden

The Most Efficient Traveler Isn’t a Bird or a Fish—It’s You on a Bike A famous graphic, now updated, compares locomotion in the animal kingdom

Remember this one? “Humans aren’t very efficient movers—until you put us on a bicycle, when we become some of the most energy-efficient land travelers in the animal kingdom.” Proven science via Scientific American @sciam.bsky.social #CityMakingMath

Iranian people in Tehran are not backing down. Despite crackdowns, large crowds appear on the streets tonight.

Update #IranProtests (63):
#Iran is nu al 48 uur afgesloten vd buitenwereld.

Er komen berichten binnen die wijzen op massamoorden in het hele land.

Wees s.v.p. de stem vd moedige Iraniërs in deze belangrijke en moeilijke tijd in de geschiedenis van Iran. #DigitalBlackoutIran

Great advice received as a postdoc: Do the easiest thing.

I was 3 years into my postdoc and juggling projects w/nothing concrete = career crisis

I went to my advisor Paul Sternberg for help. He asked what was going on & what mutant had the strongest phenotype.

"Clone the easiest one."

It worked.

"academic publishing is dominated by profit-oriented, multinational companies for whom scientific knowledge is a commodity to be sold back to the academic community who created it... The dominant four collectively generated... $12 billion in profits between 2019 and 2024."

Whooooaaaa, this is extremely neat!

And spectropolarimetry (which is the best, and what we used in my first paper too!) is at its core 💙

In a nutshell: astronomers used the polarization of light to study the shape of a supernova explosion before it interacted with surrounding material.

🔭🧪

'Schuld van links'

Beautiful image! Is this an in vitro culture of iPSC-CMs? While there's clearly still myosin around, it's also clearly in a less dense/organised state. It would be interesting to see whether they're still capable of contraction in this state.

Available via #OpenAccess.
pubs.rsc.org/en/content/a...
Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19
Huub J. Weener et al
@andriesvdm.bsky.social @rvhelden.bsky.social @middeldorps.bsky.social

bsky.app/profile/levi...

Dit is echt steengoed! 👏

Over kogels en de kanten waar ze vandaan komen.

Mooi dat de SRV podcast terug is! @hakhverdian.bsky.social stukroodvlees.nl/aflevering-1...

Our Approach to Climate Policy Has Failed. It’s Time for Climate Realism U.S. policymakers need a new strategy to confront the risks of climate change, compete in the global energy transition, and stay the course regardless of which political party is in power. A doctrine…

"climate realism" reading a lot like "sacrificing the global south and just shooting for 3 C"

www.cfr.org/article/our-...

Rapid and scalable personalized ASO screening in patient-derived organoids - Nature A scalable platform for generating patient-specific organoids for testing personalized oligonucleotide therapeutics is described.

Impressive work showcasing the use of #Cardiac #Organoids in paving the way for personalized medicine in #DMD and #GeneTherapy.

www.nature.com/articles/s41...

Engineered heart muscle allografts for heart repair in primates and humans - Nature Epicardial engineered heart muscle allografts from induced pluripotent stem cell-derived cardiomyocytes can safely and effectively remuscularize chronically failing hearts in rhesus macaques, leading ...

Incredible work! A study years in the making published in Nature. I’ve been waiting for this one.

Engineered heart muscle patches from iPSC improve cardiac function in non-human primates…and are stable/show evidence for remuscularization in a human patient! Wow! ❤️

www.nature.com/articles/s41...

Graphical abstract depicts automated setup to generate 3D cardiac mini tissues consisting of 3 cell types seeded into 384 well plates. The cardiac tissues are monitored using calcium traces to detect arrhythmias and subsequent rescue after compound addition.

🔥Super excited to drop our recent preprint🔥

biorxiv.org/cgi/content/...

Here, we automated the generation of 3D Cardiac Microtissues and performed a small high-throughput screen to identify several novel anti-arrhythmic compounds for CPVT1 🧪❤️

#Cardiosky #Science #hiPSC #Arrhythmia #Stemcell

Personalized miniorgans could speed treatments for rare diseases Method shrinks time for testing tailored RNA drugs from months to weeks

🥼 A new personalized method reduces the time spent tailoring RNA drugs—from months to weeks. In a @nature.com paper, scientists used patient-derived cardiac #organoids to predict how rare genetic diseases respond to treatments.

via @science.org

Created a starter pack focusing on disease modeling in a dish using stem cells! 🧪🔬

Please (self)nominate anyone you think should be added to the list and repost so it finds the right people ❤️

hPSC Disease Modeling: go.bsky.app/EpWsxNG

For a good general stem cell pack go here: go.bsky.app/UTW4d7b

Would love to be considered ;-)

A thread about being wrong:

5 years ago, we wrote a paper about how how newly enfranchised 16-year-olds vote in Austria. But we were wrong.

This year, @elisabethgraf.bsky.social, @schnizzl.bsky.social, Sylvia Kritzinger and I are setting the record straight: authors.elsevier.com/c/1juT5xRaZk...