Alexander Price

Stats: www.smbc-comics.com/comic/number...

(also you can buy the mug and other smbc stuff here: smbc-store.myshopify.com/products/goo...)

#smbc

The 20 years of sneezes to the face is what sent me, but every panel has a line that makes me laugh!

Excited to share that our latest story on Restrictor is out now in @genesdev.bsky.social!! Big thank you to my fellow co-first author Hanneke, Karen @adelmanlab.bsky.social and co-authors Nathalie and Allison!

EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation Abstract. Epstein-Barr virus Nuclear Antigen Leader Protein (EBNA-LP) plays a pivotal role in the transformation of B cells by Epstein-Barr virus (EBV), fu

We are excited to share our recent work:
EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation url: academic.oup.com/nar/article/...

Also serial numbers of random equipment!

The Price Lab turned two years old this week! Of course we celebrated with cake, but the cherry on top was submitting our labs very first manuscript today! Excited to see what the rest of the year holds.

Postdoc positions available! Please re-post!

Are you interested in how viruses manipulate chromatin? Are you excited to discover unknown facets of molecular biology? If so, we’d love to hear from you! Come check us out at:
avgoustilab.org

Environmental stress drives clearance of a persistent enteric virus in mice - Nature Microbiology Cage change of mice with persistent murine astrovirus infection triggers stress responses marked by corticosterone fluctuation, which is followed by CD8 T cell activation and induction of epithelial a...

Excited to share with you my postdoctoral work published today in Nature Microbiology!

www.nature.com/articles/s41...

We have known for a while that stress can impact the outcome of infectious diseases; however, we reveal in our paper that it is not always detrimental.

Environmental stress drives clearance of a persistent enteric virus in mice - Nature Microbiology Cage change of mice with persistent murine astrovirus infection triggers stress responses marked by corticosterone fluctuation, which is followed by CD8 T cell activation and induction of epithelial a...

#NewResearch

🚨Out now!

Environmental stress drives clearance of a persistent enteric virus in mice 🐀
@christinviral.bsky.social @cadwelllab.bsky.social

#MicroSky #VirusSky

www.nature.com/articles/s41...

My then 2 year old said "it means daddy dropped something", right after using it in perfect context when she dropped a crayon. Little information sponges...

Love Park in Philly today for the No Kings protest 👏👏👏

#NoKings protest in Philadelphia

From novice to expert: preparing your peer review | mBio Peer review is the process that academic journals, conferences, and funding agencies use to ensure the quality of scholarly work before it is published, presented, or funded. Reviewers for academic jo...

Excited to share our editorial on peer review, out now in #mBio! This was a mighty group effort with my mBio Early Career Editorial Board peer mentoring group
@proctordm.bsky.social and Rachy Abraham.

From novice to expert: preparing your peer review | mBio journals.asm.org/doi/10.1128/...

Gammaherpesvirus infection triggers the formation of tRNA fragments from premature tRNAs | mBio Diverse conditions of infection and cellular stress incite the cleavage of transfer RNAs (tRNAs), leading to the formation of tRNA fragments (tRFs) that can directly regulate gene expression. In our s...

Gammaherpesvirus infection triggers the formation of tRNA fragments from premature tRNAs journals.asm.org/doi/10.1128/...

Yes! We bought a starter kit during the end of the pandemic but for various reasons never got around to using it. This first one operated like a charm, but a second expired one failed to reach 37C. Analyzing the data now to see if it's actually useable.

I also thought the experience was rather painless, but our grad student (who made this slide for our following lab meeting) had different opinions?

With all that is happening it is very exciting to see the Price Lab's very first, in-house, Oxford Nanopore direct RNA seq running! Not bad for a ~3 year expired flow cell!

Sign The Open Letter to Stand Up For Science Now! Science is under siege. Trump’s latest Executive Order calls for politically appointed science commissars to evaluate research. Join us in adding your name to our open letter condemning Trump’s escala...

🚨 URGENT RESPONSE CALL 🚨

Trump’s Fool’s Gold Science EO is a dangerous sham.
It gives his appointees the power to dismiss entire bodies of research and punish researchers who fail to fall in line with his agenda.

We’ve launched an open letter.

SIGN & SHARE NOW: actionnetwork.org/petitions/op...

Congrats!!

Congrats Joe!!

Kaposi’s sarcoma-associated herpesvirus induces mitochondrial fission to evade host immune responses and promote viral production - Nature Microbiology Kaposi’s sarcoma-associated herpesvirus changes mitochondrial architecture via vBcl-2 interaction with a host NDP kinase, which triggers mitochondrial fission and inhibition of MAVS allowing for virus...

🚨 Out Now!

Kaposi's sarcoma-associated herpesvirus induces mitochondrial fission to evade host immune responses and promote viral production

#MicroSky #Virus 🦠

www.nature.com/articles/s41...

Potentially one of the coolest models I have ever seen...

Amazing!! Need to read right away to finally understand what I've been working with!

Thrilled to see our work now in @cp-molcell.bsky.social! It was an incredible privilege to do my postdoc with @ophirshalem.bsky.social and work alongside the super talented Steph Sansbury and our amazing co-authors. Excited to keep building on this research in our new lab at @rwjms.bsky.social!

Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses Sansbury and Serebrenik et al. use pooled gene tagging with in situ sequencing and high-throughput image analysis to generate a cell pool with endogenous HaloTag fusions. Hydrophobic targeting is then...

Check out our paper, now extensively revised and published in @cp-molcell.bsky.social! This has been a real tour de force led by Stephanie Sansbury and @ysereb.bsky.social and we are very excited about the findings and future potential of this approach
www.cell.com/molecular-ce...

Mysteries of adenovirus packaging | Journal of Virology DNA viruses include a diverse range of important human pathogens and powerful therapeutic tools. These agents are obligate intracellular parasites that can only replicate inside the living cells of a ...

Mysteries of adenovirus packaging journals.asm.org/doi/10.1128/...

My quote of the day

For every complex problem there is an answer that is clear, simple, and wrong.

H.L. Mencken

A nuclear RNA degradation code is recognized by PAXT for eukaryotic transcriptome surveillance Soles et al. demonstrate that the combination of a 5′ splice site and a poly(A) junction constitutes a nuclear RNA degradation code that targets RNAs for degradation by the PAXT adaptor and the RNA exosome. This study provides fundamental insight into how the RNA exosome specifically recognizes misprocessed RNAs.

Online Now: A nuclear RNA degradation code is recognized by PAXT for eukaryotic transcriptome surveillance Online now:

A nuclear RNA degradation code is recognized by PAXT for eukaryotic transcriptome surveillance Soles et al. demonstrate that the combination of a 5′ splice site and a poly(A) junction constitutes a nuclear RNA degradation code that targets RNAs for degradation by the PAXT adaptor and the RNA ex...

Amazing work! Glad to see it published by Lindsey Soles and Yongsheng Shi.

In the midst of everything it feels particularly appropriate to highlight all the amazing #RNA research taking place at #NIH!

Follow this thread to join us for our biannual #RNASymposium, this year featuring intramural research superstars!