@alex-stark.bsky.social
Scientist at IMP in Vienna. Excited about gene expression regulation and its encoding in our genomes - enhancers, transcription factors, co-factors, silencers, AI.
Messenger RNA is made in the nucleus before it is exported to the cytoplasm for translation. But how are only correctly made mRNAs chosen and remodeled in the nucleus for export?
Our new paper investigates the nuclear events leading to human mRNA export. www.nature.com/articles/s41.... (1/4)
Lastly, I’m excited to join @imbmainz.bsky.social in 2026 to start my own lab. We'll explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology. tinyurl.com/y4x29ctt
Thanks for reading! 20/20
My first @umasschan.bsky.social/@impvienna.bsky.social affiliated paper is up!
tomtom-lite is a re-implementation of tomtom targeting the ML age of genomics. Fast annotations ("what is this motif?") and simple large-scale discovery of motifs.
Check it out!
academic.oup.com/bioinformati...
🎉 Congrats to @aelewaut.bsky.social for winning the 2024 #DenisePBarlowAward! 🎖️
She carried out her PhD thesis in @obenaufa.bsky.social's lab (@impvienna.bsky.social), work published in @nature.com.
📄 Paper: rdcu.be/eQv1f
➡️ About the award: bit.ly/3iFbafP
Looks like the previous link is not working... here's a working link! www.biorxiv.org/content/10.1...
18.11.2025 20:49 — 👍 3 🔁 1 💬 0 📌 0Link to preprint: www.biorxiv.org/content/2025...
18.11.2025 15:57 — 👍 0 🔁 1 💬 1 📌 0This has been an amazing collaborative project that keeps on giving. We now have a new 3x larger eORFeome and we will dive deep into pathogen and host biology. If you are interested in scalable approaches to study effectors and their interactions with the host, get in touch! 8/8
18.11.2025 15:57 — 👍 4 🔁 1 💬 1 📌 0Our new preprint is online! Viruses, bacteria and parasites use effector proteins to evade immunity and rewire host cell pathways. Together with @AlexanderStark8, we wondered if we could systematically map what these effectors, regardless of their origin, do in human cells. 1/8
18.11.2025 15:57 — 👍 49 🔁 21 💬 2 📌 1Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
18.11.2025 14:50 — 👍 54 🔁 24 💬 0 📌 2Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways https://www.biorxiv.org/content/10.1101/2025.11.17.687821v1
18.11.2025 03:03 — 👍 1 🔁 2 💬 0 📌 0deadline tomorrow, Sept 19! www.csh-asia.org?content/2767
18.09.2025 05:43 — 👍 0 🔁 2 💬 0 📌 0
Join this year's CSH Asia Systems Biology of Gene Regulation & Genome Editing meeting in beautiful Suzhou, China, Oct 20-24. Let's bring the international communities together! Abstract deadline Sept 19! Infos and registration at csh-asia.org?content/2767. Please repost!
11.09.2025 06:09 — 👍 31 🔁 18 💬 2 📌 0
Join this year's CSH Asia Systems Biology of Gene Regulation & Genome Editing meeting in beautiful Suzhou, China, Oct 20-24. Let's bring the international communities together! Abstract deadline Sept 19! Infos and registration at csh-asia.org?content/2767. Please repost!
11.09.2025 06:09 — 👍 31 🔁 18 💬 2 📌 0
