Mechanistic Study of the Light-Initiated Generation of Free Diazoalkanes: Towards Photo-Orthogonal Synthesis
Please see the prospects for photo-orthogonal synthesis by increasing the conc. in the photostationary state and the lifetime of nonstabilized diazo compounds for stepwise reactions #ChemSky

t.co/msskifVrcS

Overcoming Challenges in Small‐Ring Transfer: Direct Decarboxylative Hydroalkylation of Alkenes via Iron‐Thiol Catalysis Cyclopropanes, especially those substituted with trifluoromethyl (CF3) groups, are valuable scaffolds in medicinal chemistry. Their enhanced bioavailability contributes to the widespread presence of ....

Really excited to share this collaboration with the Katayev group @unibe.ch showing how Fe/S catalysis can make privileged bioisosteres quickly, easily, and cheaply! Check it out in @angewandtechemie.bsky.social

onlinelibrary.wiley.com/doi/10.1002/...

Synthesis of a highly thermostable insulin by phenylalanine conjugation at B29 Lysine - Communications Chemistry Heat-lability and fibrillation of insulin pose significant challenges for insulin storage. Here, the authors report chemically modified analogs of insulin by functionalizing the ε-amine group of B29 L...

Hopefully coming soon:

🔗 nature.com/articles/s42...

A homegrown solution with global health impact — ensuring safe, stable insulin access anytime, anywhere.

Accelerated Discovery of Energy Transfer-Catalyzed Dearomative Cycloadditions through a Data-Driven Three-Layer Screening Strategy Visible-light-mediated energy transfer (EnT) photocatalysis has emerged as a highly appealing strategy for converting planar (hetero)arenes into complex, medicinally relevant, three-dimensional (3D) a...

🚀Unlocking new frontiers in photocatalysis with AI!
Our latest @jacs.acspublications.org paper presents a 3️⃣-layer screening strategy for accelerated discovery of EnT-catalyzed dearomative cycloadditions! ✨
Check this out: pubs.acs.org/doi/10.1021/...

#Photocatalysis #AIforScience #OrganicChemistry

Gas Phase Separation of Modified Peptides for Activity-Based Protein Profiling Profiling the reactivity of the proteome with amino-acid level resolution requires the identification and quantification of reacted peptides in the presence of abundant unmodified peptides. Affinity-b...

Gas Phase Separation of Modified Peptides for Activity-Based Protein Profiling | Analytical Chemistry pubs.acs.org/doi/10.1021/...

Classification of artificial intelligence applications in chemistry: from automation to digital scientific thinking This article proposes a three-level classification of artificial intelligence (AI) application in chemical sciences, reflecting the increasing degree of technology involvement in scientific and produc...

Just a few years ago, we began asking if AI can help chemists.

Now? We're already working with three distinct levels of AI in chemistry, from assistants to analysts and digital hypothesis.

Explore the roadmap in our preprint:
🔍⚗️ doi.org/10.26434/che...

#AI #Chemistry #DigitalScience #ML #DL

A general photocatalytic platform for the regio- and stereoselective β-chloroacylation of alkenes and alkynes using a heteroleptic copper(I) complex Nature Catalysis, Published online: 24 June 2025; doi:10.1038/s41929-025-01357-yThere are issues hampering the wider adoption of atom transfer radical addition (ATRA) of aroyl chlorides to access β-chloroacyl derivatives via photoredox catalysis. Now, Mandal et al. report the regioselective chlorocarbonylation of alkenes and alkynes via visible-light-mediated ATRA of aroyl chlorides catalysed by a heteroleptic Cu(I) complex.

New online! A general photocatalytic platform for the regio- and stereoselective β-chloroacylation of alkenes and alkynes using a heteroleptic copper(I) complex

Semi‐Automated Pipeline for Transition State Search of Molecular Photoswitches A semi-automated pipeline for the transition state search of molecular switches (PiTS3) is reported, which facilitates the search, optimization, and conformational analysis of transition states of ph...

Our pipeline to compute thermal barriers of photoswitches💡 is out!🥳 We especially focused on NBDs for MOST🔋 and imines, but also stilbenes and DAEs. Try it out! You need just chemdraws and freeware to get libraries computed

doi.org/10.1002/cptc...

Alternative Mechanism of Enzymatic Photocontrol by Azobenzene Azobenzene is a widely recognized tool for achieving artificial spatiotemporal control of enzyme activity through the use of light. Photocontrol reversibility is typically based on photostationary sta...

An unexplored avenue for azobenzene #photoswitching with simultaneous irradiation at 365:420 nm!
Congrats to Ranit, Alba and especially Caroline! @pubs.acs.org #ChemSky
Alternative Mechanism of Enzymatic Photocontrol by Azobenzene | ACS Catalysis pubs.acs.org/doi/10.1021/...

Harnessing carbene polarity: Unified catalytic access to donor, neutral, and acceptor carbenes Metal carbenes are highly useful intermediates in organic synthesis. However, not all classes of carbene polarity are catalytically accessible, nor are there common precursors known to synthesize all ...

Harnessing carbene polarity: Unified catalytic access to donor, neutral, and acceptor carbenes | Science www.science.org/doi/10.1126/...

Great work Durga!

Over the moon that the first paper from Anja's studies on metal chelate rotaxanes is now online in @angewandtechemie.bsky.social. doi.org/10.1002/anie...
Massive congratulations Anja,
@daisypooler.bsky.social Huseyn, Monika and @screspi.bsky.social 🥳🎉🎊🍀🥃

Thread below --》

🚀Propellane→MCB→BCH: Our work on the first sigmatropic rearrangement with [1.1.1]propellane for accessing functionalized MCBs and their application in the synthesis of BCHs is out @natcomms.nature.com. Thank you,
@ANRFIndia and @iiscbangalore, for the funding.
www.nature.com/articles/s41...

The next masterpiece from Matthias focusing on Coulombic dyads as new #photocatalyst class has been accepted in ACIE. Higher quantum yields in red-light catalysis by adding an inexpensive salt to use #Os as efficiently as possible. onlinelibrary.wiley.com/doi/10.1002/... @labheinze.bsky.social

A new concept for a better insight! Congratulations!

Magnetic Stirring May Cause Irreproducible Results in Chemical Reactions Magnetic stirrers, the most widely used and ubiquitous devices for performing chemical reactions in laboratory settings, may cause reproducibility problems. Reproducibility in a range of chemical proc...

Shedding light on an overlooked significant facet:
Magnetic stirrers - used daily in millions of labs - may silently sabotage reproducibility!
pubs.acs.org/doi/10.1021/...

New gift for the lab: an ammonite8 flow eChem cell! ⚡️ Time to electrolyse grams of compounds now 😎 #UniofGreenwich #NewToy #ChemSky

Magnetic Stirring May Cause Irreproducible Results in Chemical Reactions Magnetic stirrers, the most widely used and ubiquitous devices for performing chemical reactions in laboratory settings, may cause reproducibility problems. Reproducibility in a range of chemical proc...

One of the unspoken frustrations for many chemists, finally unpacked by my PhD advisor Valentine Ananikov and his team in JACS Au. Reproducibility is everything in science, and this shows why yesterday’s reaction doesn’t always work today

A must read:
doi.org/10.1021/jacs...

🦋RPC@BCB: Our work on strain-enabled radical-polar crossover annulation to access hetero-bicyclo[3.1.1]heptanes just out in @angewandtechemie.bsky.social . Thanks to @iiscbangalore and @ANRFIndia for the financial support.
🔗https://doi.org/10.1002/anie.202506747

The work of Xingyu Liu @xingyuliu9595.bsky.social in collaboration with Wei Cai in Beat Fierz @beatfierz.bsky.social group @lcbm-epfl.bsky.social and Anne-Sophie Chauvin on peptide-cyanoarenes used as photocatalysts is now accepted in @angewandtechemie.bsky.social !
doi.org/10.1002/anie...

Nadja Simeth @nadjasimeth.bsky.social, @unigoettingen.bsky.social, and co-researchers synthesized novel N-acylpyrazole-based photoswitches and conducted a comparative study w/ 33 phenylazopyrazoles to examine their photoswitching properties: 🔗 https://tinyurl.com/uhkmtvxu
#BJOC #DiamondOpenAcces 💎 🔓

🏠Housanes: Our work on the stereoselective synthesis of (oxa)housanes and their skeletal remodeling to access bicyclic imides is out in @chemicalscience.rsc.org. Thank you, @ANRFIndia @iiscbangalore, for the funding.
🔗 doi.org/10.1039/D5SC...

Development of an Organoautocatalyzed Double σ‐Bond C(sp2)‐N Transamination Metathesis Reaction Organoautocatalyzed transamination metathesis of cyclic tertiary amines is disclosed as a high-yielding, scalable reaction that proceeds under mild, catalyst-free conditions. It operates via a multi-....

Happy to share the final version of our paper! We report #waste-reducing, #cost-efficient synthesis of N-substituted #dihydropyridines. No catalysts or harsh reagents needed! #Organoautocatalysis #Transamination #GreenChem #AngewChem

#ChemSky #AcademicSky

onlinelibrary.wiley.com/doi/10.1002/...

Practical electrochemical hydrogenation of nitriles at the nickel foam cathode We report a scalable hydrogenation method for nitriles based on cost-effective materials in a very simple two-electrode setup under galvanostatic conditions. All components are commercially and readil...

A simple and sustainable electrochemical method !
@rnarobe.bsky.social
doi.org/10.1039/D4GC...

⚡Deconstruction of Cyclic Ketones: Our work on the electrochemical interrupted Dowd–Beckwith reaction for deconstructive functionalization of cyclic ketones is out in @angewandtechemie.bsky.social‬. Thanks to @iiscbangalore and @ANRFIndia for the financial support.
🔗 shorturl.at/LfAIA

Electrochemically induced Meerwein arylation as a green strategy for the synthesis of arylbenzoquinone derivatives under batch and flow conditions - Scientific Reports Scientific Reports - Electrochemically induced Meerwein arylation as a green strategy for the synthesis of arylbenzoquinone derivatives under batch and flow conditions

Electrochemically induced Meerwein arylation as a green strategy for the synthesis of arylbenzoquinone derivatives under batch and flow conditions nature.com/articles/s41...

Green‐light Cerium Photocatalysis enabled by Pyridine N‐oxide Ligands Abstract: We report pyridine N-oxides as neutral ligands in cerium photocatalysis. By using those neutral ligands, photoactive Ce(IV)-species are generated, that show an extensive bathochromic shift ...

The effective utilization of green light in the CH-hydrazination of small molecules under very mild photocatalytic conditions.
Congrats to Nico! #ChemSky #photocatalysis
doi.org/10.1002/ejoc...

Reactivity of Superbasic Carbanions Generated via Reductive Radical‐Polar Crossover in the Context of Photoredox Catalysis Photocatalytic reactions with a reductive radical-polar crossover (RRPCO) involve intermediates with carbanionic reactivity. These are best described as free carbanions. Reactions with such carbanion...

Proud of Sascha that his collaboration is a most read article published from our University #openaccess #ChemSky #photocatalysis
doi.org/10.1002/anie...

Anthraquinone Sulfonates as Water‐Soluble Photocatalysts: Synthetic Applications and Perspectives The development of photochemistry in water is rapidly advancing, and the demand for water-soluble photocatalysts is increasing. Accordingly, anthraquinone sulfonates are interesting options for the a...

We are excited to present our perspective. We hope our work will inspire researchers for advancing the field of photocatalysis in water and prioritize the use of greener reaction conditions @chemistryeurope.bsky.social #photocatalysis #Chemsky
Congrats to Daniel and Andrey!

doi.org/10.1002/cptc...