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Peter H. Bellotti

@peterbellottti.bsky.social

Eppur si muove! Organic chemist and bookworm - ๐Ÿ“NYC

116 Followers  |  304 Following  |  31 Posts  |  Joined: 19.11.2024  |  1.8339

Latest posts by peterbellottti.bsky.social on Bluesky

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Gas Phase Separation of Modified Peptides for Activity-Based Protein Profiling Profiling the reactivity of the proteome with amino-acid level resolution requires the identification and quantification of reacted peptides in the presence of abundant unmodified peptides. Affinity-b...

Gas Phase Separation of Modified Peptides for Activity-Based Protein Profiling | Analytical Chemistry pubs.acs.org/doi/10.1021/...

22.07.2025 12:49 โ€” ๐Ÿ‘ 3    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Global Protein-Ligand Binding Affinity Profiling via Photocatalytic Labeling Protein-ligand binding, selectivity, and affinity dictate the effects of drugs and endogenous molecules in cells. Currently, potential protein-ligand interactions are identified by qualitative interpretation of proteomic, transcriptomic, or genomic data, then binding affinities of hits are measured using purified proteins or engineered reporter systems to validate and quantify the strength of individual interactions. Few methods enable simultaneous target identification and biophysical affinity measurement, and these either apply to specific enzyme classes or proteins with ligand dependent shifts in stability. Here we describe a general platform, termed Affinity Map, which leverages competitive binding analysis, high fidelity photocatalytic labeling, and high throughput proteomics for global quantitative binding affinity profiling. We show that this method is applicable to major classes of ligands, including small molecules, linear peptides, cyclic peptides, and proteins, and can measure affinities between unmodified ligands and proteins in cell lysates, organ extracts, and live cell surfaces. ### Competing Interest Statement J.B.G., N.Y., C.D.W., and S.P. are inventors on a provisional patent application (63/720,063) filed by Cornell University related to this work. National Institute of General Medical Sciences, https://ror.org/04q48ey07, R35GM147449, T32GM136640-TAN, R35GM147449-02S1
07.07.2025 16:12 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Mondo reale: andare avanti a lamentele, ma non si va al seggio!

08.06.2025 22:15 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Che conseguenze? Che c'รจ un disinteresse generale?

08.06.2025 17:45 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

The house on Via Gemito by Domenico Starnone

07.05.2025 17:10 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Albert Einstein College of Medicine Launches Data Science Institute

Today, Einstein announced the launch of its new Data Science Institute. The dynamic, state-of-the-art resource will strengthen researchersโ€™ ability to harness vast amounts of data for biomedical breakthroughs and innovations in scientific discovery and patient care. #datascience #research #MedSky

06.05.2025 19:12 โ€” ๐Ÿ‘ 5    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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BACCARA is hiring PhD students in battery research! ๐Ÿ”‹โš—๏ธ๐Ÿ˜€

BACCARA = "International Graduate School of Battery Chemistry, Characterization, Analysis, Recycling and Application" @uni_muenster
Apply until June 1st.
www.uni-muenster.de/Baccara/inde...

06.05.2025 14:15 โ€” ๐Ÿ‘ 5    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Huge congratulations to Dr. Ranjini on successfully defending her PhD! ๐Ÿฅณ Your research always kept us excited in all the right states. ๐Ÿ’ก Wishing you all the best for your bright path ahead! ๐ŸŒŸ๐Ÿ“ธ๐Ÿงช #PhDoneย #Photochemistry

29.04.2025 17:48 โ€” ๐Ÿ‘ 13    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

There is definitely AT LEAST one defensive error here. Thus, by definition, not an inside-the-park homerun

28.04.2025 09:40 โ€” ๐Ÿ‘ 3    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Happy #InternationalLabDay! ๐ŸŒ๐Ÿงช
Celebrating experiments that fail, the occasional hit, and especially the teams that make it all possible. ๐Ÿ‘ฉ๐Ÿปโ€๐Ÿ”ฌ๐Ÿ‘๐ŸปLet us know what your favorite piece of lab equipment is! โš— #Science #LabLife

23.04.2025 10:56 โ€” ๐Ÿ‘ 8    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Wordle 1,402 2/6

๐ŸŸฉโฌœ๐ŸŸจ๐ŸŸจโฌœ
๐ŸŸฉ๐ŸŸฉ๐ŸŸฉ๐ŸŸฉ๐ŸŸฉ

21.04.2025 23:50 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Bifunctional reagents and strain-releaseโ€ cycloaddition โ€“ one reagent for the best of both worlds! ๐Ÿซฑ๐Ÿผโ€๐Ÿซฒ๐Ÿฝ
Check out our latest publication on cyclic bifunctional reagents and in situ generated 2H-azirines in @jacs.acspublications.org:
pubs.acs.org/doi/10.1021/...
#OrganicChemistry #ChemTwitter

14.04.2025 12:13 โ€” ๐Ÿ‘ 17    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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13.04.2025 11:46 โ€” ๐Ÿ‘ 8    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1

International Booker prize

11.04.2025 20:39 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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From Structure to Function: Designing Iridium Catalysts with Spin-Forbidden Excitation for Low-Energy Light-Driven Reactions Herein we describe a comprehensive study of ligand effects on optoelectronic properties of a series of Ir(III) catalysts which undergo formally spin-forbidden excitation using low-energy light. We dem...

From Structure to Function: Designing Iridium Catalysts with Spin-Forbidden Excitation for Low-Energy Light-Driven Reactions | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...

10.04.2025 19:09 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Interpreting Nature | Jed Perl โ€œCรฉzanne Drawing,โ€ at the Museum of Modern Art, is a mindblower of a show. More than 250 works on paper, among them dozens of watercolors, reveal Paul

www.nybooks.com/articles/202...

10.04.2025 16:15 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

"An Ordinary Youth" by Walter Kempowski

10.04.2025 02:20 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Perfection is on the The International Booker shortlist! ๐Ÿฅณ

Congrats to Vincenzo Latronico, Sophie Hughes, and the other authors and translators. Many thanks to the wise judges. Vincenzo has events on Thurs & Fri in NYC. They will now be celebrations as much as literary talks.

08.04.2025 14:09 โ€” ๐Ÿ‘ 22    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Phenothiazine sulfoxides aren't just oxidation productsโ€”they're photocatalysts! ๐ŸŒŸTogether with the @WengerOliver group, we investigated how they activate malonyl peroxides to synthesize ฮณ-lactones from simple olefins.

Check it out in @J_A_C_S ๐Ÿ‘‰

04.04.2025 12:37 โ€” ๐Ÿ‘ 10    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

His translation of Sand is one of my favorite books of the year so far. RIP

02.04.2025 02:35 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Lugansky - Scriabin ร‰tude Op. 8, No. 12. Patetico
YouTube video by Enchanted Wanderer Lugansky - Scriabin ร‰tude Op. 8, No. 12. Patetico

youtube.com/watch?v=SaIM...

02.04.2025 00:48 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Match Day 2025 | Albert Einstein College of Medicine
YouTube video by Albert Einstein College of Medicine Match Day 2025 | Albert Einstein College of Medicine

Itโ€™s Match Dayโ€”the moment when all the hard work and late nights pay off. Einsteinโ€™s graduating medical students open their envelopes, revealing where they will spend the next three to five years as residents. youtu.be/wCpkWyq6i3k?...
#Match2025 #MedSky #premed

31.03.2025 20:56 โ€” ๐Ÿ‘ 0    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

On Thursday, I tried to get a copy at Center for Fiction in BK with no success. Sold out! Congrats!

21.03.2025 15:42 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Bach - Ruht wohl, ihr heiligen Gebeine from St John Passion BWV 245 | Netherlands Bach Society
YouTube video by Netherlands Bach Society Bach - Ruht wohl, ihr heiligen Gebeine from St John Passion BWV 245 | Netherlands Bach Society

youtube.com/watch?v=O9bO...

21.03.2025 00:55 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Join the Glorius Group at the intersection of cheminformatics, data science & synthetic chemistry! We use AI, HTE & HPC to advance catalysis & materials. PhD/Postdoc opportunities with funding available! Reach out if you're interested! ๐Ÿ“ฉ
#Cheminformatics #DataScience #Chemistry

13.03.2025 15:27 โ€” ๐Ÿ‘ 20    ๐Ÿ” 9    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Maurizio Serra presents "Malaparte: A Biography" at New York University
YouTube video by CasaItalianaNYU Maurizio Serra presents "Malaparte: A Biography" at New York University

Yesterday's conversation on Curzio Malaparte between Maurizio Serra (author of Malaparte: A Biography), Stephen Twilley (translator), Franco Baldasso, and Andrea Capra was recorded and can be watched hereโ€”

12.03.2025 20:00 โ€” ๐Ÿ‘ 11    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Oxidative amination by nitrogen atom insertion into carbon-carbon double bonds The synthesis of nitrogen-containing molecules through carbonโ€“nitrogen (Cโ€“N) bond formation is critical for the discovery and preparation of medicines, agrochemicals, and materials. Here, we report th...

Also in @science.org for chemsky this week, we have two methods of turning olefins into nitriles, respectively from Bill Morandi's group and Ning Jiao's group ๐Ÿงช

www.science.org/doi/10.1126/...

06.03.2025 20:15 โ€” ๐Ÿ‘ 49    ๐Ÿ” 8    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

This guy doesn't know shit! It's appalling how oblivious him and the orange menace are

04.03.2025 12:10 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Yes - Roundabout (Fragile)

28.02.2025 00:22 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

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