David Lalaouna

The iron-regulated small regulatory RNA IsrR modulates expression of genes utilized for dioxygen metabolism and heme synthesis in Staphylococcus aureus | mBio Staphylococcus aureus causes numerous and varied infections in mammals, making it a significant public health burden and concern. The prevalence of S. aureus infections is due to its robust repertoire...

The iron-regulated small regulatory RNA IsrR modulates expression of genes utilized for dioxygen metabolism and heme synthesis in Staphylococcus aureus | mBio journals.asm.org/doi/10.1128/...

An RNA regulates iron homeostasis and host mucus colonization in Bacteroides thetaiotaomicron Symbiotic bacteria in the human intestinal microbiota provide many pivotal functions to human health and occupy distinct biogeographic niches within the gut. Yet the molecular basis underlying niche-s...

New preprint from the lab, in collaboration with Wenhan Zhu (U Vanderbilt): using dual RNA-seq during B. theta colonization of the host mucous layer, we identify IroR--an iron-response sRNA that tunes capsule expression and facilitates adaptation to iron limitation.
doi.org/10.1101/2025.09.08.672848

"What makes S. aureus such a difficult vaccination candidate?" Here are some answers:

A huge thank you to all our collaborators ! 🙏

3/3 ZinS emerged via horizontal gene transfer of the zinP mRNA and neofunctionalization of its 3' UTR 🔄

2/3 ZinS is a dual-function sRNA encoding a small peptide, ZinP

1/3 We have revealed ZinS as the first small regulatory RNA involved in a zinc-sparing response in bacteria. ZinS (formerly RsaX20) negatively regulates Zn-dependent enzymes, including alcohol dehydrogenase to spare this essential element for S. aureus survival and virulence.

🚨 New Preprint Alert 🚨

Our latest work, A Zur-dependent regulatory RNA involved in maintaining zinc homeostasis in Staphylococcus aureus, is now live on bioRxiv! 🧬🦠📄

Check it out here: www.biorxiv.org/content/10.1...

What makes a small RNA work? Abstract. Bacterial small RNAs (sRNAs) are key regulators of gene expression, interacting with target messenger RNAs (mRNAs) through imperfect base pairing

New review out in @narjournal.bsky.social!
🔎 What makes a small RNA work?
We discuss:
🧬 Sequence features
🤝 Hfq, ProQ & RNA chaperones
✂️ RNase E & degradosome interactions
🧪 Lessons for RNA design
📖 Read: academic.oup.com/nar/article-...
@unswbabs.bsky.social @davidlalaouna.bsky.social @Jai Tree

“Mes collègues aux Etats-Unis me disent qu'ils ont peur”, entretien avec Olivier Berné Suite à l’élection de Donald Trump et à ses mesures concernant la recherche scientifique, la mobilisation Stand Up for Science aura lieu vendredi 7 mars aux États-Unis.

Suite aux mesures de Donald #Trump concernant la recherche scientifique, #StandUpforScience aura lieu vendredi aux États-Unis. En France, des scientifiques se joignent au mouvement. Entretien avec Olivier Berné, dir. de recherche et co-organisateur de SUfS France

www.larecherche.fr/politique-po...

Poste d’ingénieur(e) de recherche CNRS – 18 mois – Marseille
Rejoignez notre équipe sur un projet de prématuration du CNRS ! Nous recherchons un(e) ingénieur(e) de recherche spécialisé(e) en microbiologie, biologie moléculaire et en microscopie.
🫵 🔬👨‍🔬👩‍🔬

emploi.cnrs.fr/Offres/CDD/U...

Biofilms in Bacterial Pathogenicity👇🏼

with Nicola @bacteriacities.bsky.social (cool story on Bacillus subtilis biofilm colonies and competitiveness within) and
Jean-Marc @jmghigolab.bsky.social

Applications are open for the 2025 GRS/GRC on Staphylococcal Diseases! Make sure to get your abstracts submitted for the potential to present your work in beautiful Barcelona! www.grc.org/staphylococc...

One more week to get your applications submitted

Looking for a postdoc position? Want to apply your biochemistry skills to answer interesting evolutionary questions of how metalloenzymes evolve? Join my growing team in Warsaw at @IBBPAS. We're seeking a talented new postdoc to work on the superoxide dismutases.
ibb.edu.pl/app/uploads/...

The mutational landscape of Staphylococcus aureus during colonisation Nature Communications - The authors applied a genomic and evolutionary approach to study Staphylococcus aureus in host adaptation during colonisation revealing signals of adaption in metabolic...

Our paper investigating the mutational landscape during Staphylococcus aureus during colonisation is out now rdcu.be//d55l3
@fcic.bsky.social @sangerinstitute.bsky.social @ibv-csic.bsky.social University of Cambridge @julianparkhill.bsky.social