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Tomas Hessler

@tomas-hessler.bsky.social

Postdoc at UC Berkeley Metagenomics | Microbial ecology | Phage | Bioprocess engineering πŸ‡ΏπŸ‡¦ views are my own

105 Followers  |  135 Following  |  1 Posts  |  Joined: 31.12.2023  |  2.048

Latest posts by tomas-hessler.bsky.social on Bluesky

‼️Diamond Lab is considering potential a new postdoctoral researcher. If you have strong interests in microbiomes, metagenomics, machine learning, or rumen biology drop us a line and shoot us a CV!

01.08.2025 22:57 β€” πŸ‘ 4    πŸ” 4    πŸ’¬ 0    πŸ“Œ 1
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Phage-based delivery of CRISPR-associated transposases for targeted bacterial editing

"Here, we engineer phage Ξ» with CRISPR-associated transposases to enable flexible bacterial genome manipulation, including in a mixed microbial community context."

www.pnas.org/doi/10.1073/...

29.07.2025 17:26 β€” πŸ‘ 10    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0

We (with Clement Coclet, not on Bsky) had the chance to work on a broad "state of viromics" review. We tried to use this to give an overview of how the field changed over the last ~ 15 years, and also what we think are some of the major remaining challenges. Full-text access at -> rdcu.be/excHt

22.07.2025 15:06 β€” πŸ‘ 79    πŸ” 39    πŸ’¬ 2    πŸ“Œ 2

New review article with @mmdesai.bsky.social is out today! Grateful for the opportunity to contribute something we hope will serve the community well

21.07.2025 17:30 β€” πŸ‘ 43    πŸ” 15    πŸ’¬ 3    πŸ“Œ 0
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Junior, Assistant, or Associate Specialist – Xue Lab University of California, Irvine is hiring. Apply now!

The Xue lab at UC Irvine is looking for a staff scientist to support our work investigating how microbes interact and evolve in the gut microbiome! Open to a wide range of previous experience levels, see ad for more.
recruit.ap.uci.edu/JPF09601

17.07.2025 20:32 β€” πŸ‘ 113    πŸ” 111    πŸ’¬ 0    πŸ“Œ 3

🚨 Fresh from the press! We created and analyzed over 100 in vitro cyanobacterial consortia using well-characterized model cyanobacterial hosts to better understand how cyanobacteria recruit and interact with their microbiomes.

Check it out: doi.org/10.1093/isme...

11.07.2025 13:07 β€” πŸ‘ 43    πŸ” 22    πŸ’¬ 3    πŸ“Œ 4
Bridging the scales: what can microbial ecologists learn from classic ecology?

Beautiful new review paper in preprint bridging microbial ecology and classic ecology led by Maggie Vogel, @olimeacock.bsky.social and @annasophieweiss.bsky.social, also by @juliensluneau.bsky.social and @lambdapp.bsky.social from our lab (not me :)) ecoevorxiv.org/repository/v...

01.07.2025 08:25 β€” πŸ‘ 39    πŸ” 26    πŸ’¬ 1    πŸ“Œ 0

We’re happy to share our preprint where applied phages to Microbiomes to test microbial interaction hypotheses - without losing the relevance of the community.

Bonus: using SNPs we studied how our targeted organism recovers from infection, and find how the community likely influences this process.

22.06.2025 20:49 β€” πŸ‘ 14    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0

over a year later, this one out today!

link.springer.com/article/10.1...

16.06.2025 16:35 β€” πŸ‘ 33    πŸ” 14    πŸ’¬ 3    πŸ“Œ 0

Our structural core gene pipeline Unicode is now published at GBE
πŸ“„ doi.org/10.1093/gbe/...

Please also check out @dongwookkim.bsky.social’s
🧡 bsky.app/profile/dong...

03.06.2025 17:19 β€” πŸ‘ 43    πŸ” 19    πŸ’¬ 2    πŸ“Œ 0
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Circular 23S rRNA within archaeal ribosomes The ribosomal RNAs (rRNAs) that form the core of ribosomes are believed to occur as linear molecules. Here, we investigated rRNAs from diverse and mostly uncultivated archaea and found evidence that, ...

Happy to share our recent work on rRNA processing and conformation: www.biorxiv.org/content/10.1...

Huge thanks to @ppenev.bsky.social @Amos Nissley @Dipti Nayak @Rohan Sachdeva @jhdcate.bsky.social @Jill Banfield @banfieldlab.bsky.social !!

29.04.2025 02:34 β€” πŸ‘ 12    πŸ” 7    πŸ’¬ 0    πŸ“Œ 1
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Microbial model communities reveal widespread auxotrophies in abundant bacteria
Our results highlight the value of cultivating microorganisms in groups to cultivate:
1) abundant microorganisms
tinyurl.com/miintmodcom

29.04.2025 05:00 β€” πŸ‘ 23    πŸ” 11    πŸ’¬ 2    πŸ“Œ 0
A graph showing reported measles cases in the United States. The line shows that there were regularly 400-600,000 cases each year until 1963, when the measles vaccine was licensed, at which point cases plummet. In 2000, the elimination of measles was declared.

A graph showing reported measles cases in the United States. The line shows that there were regularly 400-600,000 cases each year until 1963, when the measles vaccine was licensed, at which point cases plummet. In 2000, the elimination of measles was declared.

Vaccines have granted families in wealthy countries the luxury of forgetting what measles, polio, rubella, and other preventable diseases are like.

We're looking at how many millions of lives vaccines have saved.

Read the full story: https://go.nature.com/42Aj3Y8

08.04.2025 09:55 β€” πŸ‘ 232    πŸ” 88    πŸ’¬ 3    πŸ“Œ 9
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Genetics, ecology and evolution of phage satellites Nature Reviews Microbiology - In this Review, PenadΓ©s et al. explore the genetics, potential origins and life cycle of phage satellites, and they discuss the impact of these elements on the...

If you are interested in phage satellites, we hope you'll enjoy this. Fun collaboration with the Rocha, Seed, Bikard, and Chen labs! rdcu.be/efkvG

27.03.2025 11:28 β€” πŸ‘ 52    πŸ” 19    πŸ’¬ 0    πŸ“Œ 0
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Beautiful new study reveals how 𝘚𝘡𝘳𝘦𝘱𝘡𝘰𝘀𝘰𝘀𝘀𝘢𝘴 𝘱𝘺𝘰𝘨𝘦𝘯𝘦𝘴 bacteria prefer to acquire CRISPR immunity from dormant (lysogenic) phagesβ€”not active lytic ones. A clever way to survive and remember without getting destroyed.

Keith et al., Cell Host Microbe
#CRISPR #phage

www.cell.com/cell-host-mi...

23.03.2025 00:07 β€” πŸ‘ 36    πŸ” 13    πŸ’¬ 1    πŸ“Œ 1
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GitHub - shandley/awesome-virome: A listing of software, tools and databases useful for virome analysis A listing of software, tools and databases useful for virome analysis - shandley/awesome-virome

Check out this list of awesome #virome tools and be sure to add yours!

github.com/shandley/awe...

#phagesky #microsky

12.03.2025 20:46 β€” πŸ‘ 52    πŸ” 31    πŸ’¬ 0    πŸ“Œ 0
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Postdoctor, 2 years, in predicting the evolution of antibiotic resistance The Department of Molecular Biology seeks a postdoctoral researcher who will work with forecasting and steering experimental evolution of antibiotic resistance. The employment is full-time for two yea

We have a 2-year postdoc position available in the Lind Lab at UmeΓ₯ University, Sweden! Predicting and steering experimental evolution of antibiotic resistance in Pseudomonas aeruginosa. Reposts appreciated.
umu.varbi.com/en/?jobtoken...

13.03.2025 13:13 β€” πŸ‘ 18    πŸ” 49    πŸ’¬ 0    πŸ“Œ 2
Ben Adler  & Muntathar Jamal Al-Shimary

Ben Adler & Muntathar Jamal Al-Shimary

Phage genomes are full of mysterious proteins that could be harnessed to create new genomic tools. IGI's @doudna-lab.bsky.social & @cresslab.bsky.social with co-first authors @benadler.bsky.social & Muntathar Jamal Al-Shimary detail a new way to exploring phage genomes: ow.ly/uucL50V77n0 πŸ§ͺ🦠🧬

13.03.2025 17:58 β€” πŸ‘ 22    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0
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Our Phage infection/T6S story is finally out @embojournal.org! "Surface-mediated bacteriophage defense incurs fitness tradeoffs for interbacterial antagonism" Led by my wonderful team at Academia Sinica!
www.embopress.org/doi/full/10....

10.03.2025 13:43 β€” πŸ‘ 10    πŸ” 7    πŸ’¬ 2    πŸ“Œ 0
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CRISPRi-ART enables functional genomics of diverse bacteriophages using RNA-binding dCas13d - Nature Microbiology Leveraging RNA-targeting dCas13d enables selective interference with phage protein translation and facilitates measurement of phage gene fitness at a transcriptome-wide scale.

It is finally out!

Muntathar Al-Shimary, @doudna-lab.bsky.social , @cresslab.bsky.social and I present a gene knockdown tool that works in diverse bacteriophages: CRISPRi through antisense RNA Targeting (CRISPRi-ART)!

Check it out @naturemicrobiol.bsky.social
www.nature.com/articles/s41...

26.02.2025 16:43 β€” πŸ‘ 93    πŸ” 47    πŸ’¬ 7    πŸ“Œ 3
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Sporadic distribution of a new archaeal genetic code with all TAG codons as pyrrolysine Numerous genetic codes developed during the evolution of Eukaryotes and three are known in Bacteria, yet no alternative genetic code has been established for Archaea. Some bacterial and archaeal prote...

We discovered the first alternative genetic code in Archaea!

www.biorxiv.org/content/10.1...

08.11.2024 20:13 β€” πŸ‘ 243    πŸ” 102    πŸ’¬ 8    πŸ“Œ 10
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PLOS statement on recent US Executive Orders and scientific integrity - The Official PLOS Blog Since its founding over twenty five years ago PLOS has been dedicated to advancing open science, ensuring that knowledge is accessible to…

PLOS has issued a statement on recent US Executive Orders and scientific integrity.

We are determined to stand firmly behind our mission, our values and our principles, and against any attempt at censorship or undermining of the core principles of scientific inquiry.

plos.io/3D4O8cH

21.02.2025 15:41 β€” πŸ‘ 1092    πŸ” 422    πŸ’¬ 27    πŸ“Œ 62
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Design and regulation of engineered bacteria for environmental release - Nature Microbiology Chemla et al. review the release of bacteria into the environment and propose engineering strategies to help improve performance and reduce risk.

Design and regulation of engineered bacteria for environmental release

-in @naturemicrobiol.bsky.social from Christopher Voigt

www.nature.com/articles/s41...

20.02.2025 10:27 β€” πŸ‘ 12    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
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Quorum sensing and DNA methylation play active roles in clinical Burkholderia phase variation | Journal of Bacteriology Some Burkholderia species are pathogenic to plants, animals, or humans. In immunocompromised individuals, and people suffering from cystic fibrosis, infection from the Burkholderia cepacia complex (Bc...

New paper out! Phenotypic variation is a feature of several Burkholderia species. We found that quorum sensing and adenosine DNA methylation are two antagonistic systems independently controlling phase variation in B. ambifaria. Great work by @pmlcoulon.bsky.social journals.asm.org/doi/10.1128/...

17.02.2025 17:57 β€” πŸ‘ 11    πŸ” 8    πŸ’¬ 0    πŸ“Œ 1

Email the leadership of the ASM to protest their decision to obey in advance and pulling DEI related, previously published content and papers from their website. I personally would threaten leaving ASM, avoiding ASM meetings, and refuse reviewing for them. @vscooper.micropopbio.org

03.02.2025 05:49 β€” πŸ‘ 22    πŸ” 10    πŸ’¬ 0    πŸ“Œ 1
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SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome - Nature Microbiology Split-And-pool Metagenomic Plot-sampling sequencing (SAMPL-seq) can be applied to complex microbial communities to reveal spatial co-localization of microbes at the micron scale.

Happy to share our new paper in @naturemicrobiol.bsky.social on mapping spatial relationships of the human gut microbiome. We identified distinct spatial hubs between gut bacteria that reflect sub-community assemblies at the micron-scale. Led by Miles Richardson & co.
www.nature.com/articles/s41...

03.02.2025 14:46 β€” πŸ‘ 89    πŸ” 36    πŸ’¬ 0    πŸ“Œ 0
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Siderophore synthetase-receptor gene coevolution reveals habitat- and pathogen-specific bacterial iron interaction networks Coevolving siderophore genes shape bacterial iron networks, unveiling the complexity of cheating across habitats and lifestyles.

We derive iron-siderophore interaction networks among Pseudomonas strains from sequencing data. One key insight: natural strains form dense networks, whereas pathogens are loners. With @frimanscience.bsky.social @zhiyuanli.bsky.social & Nanjing colleagues
www.science.org/doi/10.1126/...

16.01.2025 09:29 β€” πŸ‘ 58    πŸ” 35    πŸ’¬ 1    πŸ“Œ 2
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Seed tuber microbiome can predict growth potential of potato varieties - Nature Microbiology Time-resolved drone imaging of potato crop development and seed tuber microbiome data can be used to predict potato vigour, or growth potential, in next-season crops in trial fields.

Our latest research, "Seed tuber microbiome can predict growth potential of potato varieties," is now published online on Nature Microbiology! πŸ₯”βœ¨
Check out the full paper here: www.nature.com/articles/s41...
Let's connect and grow ideas together!

08.01.2025 17:46 β€” πŸ‘ 28    πŸ” 10    πŸ’¬ 0    πŸ“Œ 1
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Two decades of bacterial ecology and evolution in a freshwater lake Nature Microbiology - A 471-metagenome time series from Lake Mendota in Wisconsin, USA, reveals seasonal and decadal shifts in bacterial functional and ecological dynamics, especially in response...

After 24 years of work, I’m thrilled to announce the TYMEFLIES dataset, which comprises metagenomes from Lake Mendota (Madison, WI), collected roughly every 10 days (471 samples) for 20 years! @quendi.bsky.social @robinrohwer.bsky.social

rdcu.be/d5put

A thread…

03.01.2025 11:44 β€” πŸ‘ 246    πŸ” 101    πŸ’¬ 3    πŸ“Œ 3
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Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains Gu etΒ al. show that bacterial Shedu proteins are a broad family of immune nucleases with diverse N-terminal sensor domains that regulate a common C-terminal DNA endonuclease domain. They find that a major class of Shedu nucleases degrades injected phage DNA to halt phage DNA replication and disrupt infection.

Grateful for the feedback we got from the referees, further strengthening our paper. Check the final manuscript for all the new additions :).

Also check out the complementary work on Shedu led by Yajie Gu from the @kevincorbett.bsky.social lab!

www.cell.com/molecular-ce...

31.12.2024 15:38 β€” πŸ‘ 16    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0

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