Linda Sinclair

Iron and the immune system - Nature Reviews Immunology Iron is crucial for cellular metabolism, but its availability varies greatly within and between individuals and populations. This Review highlights how iron regulates innate and adaptive cellular and ...

2 new efforts: from Megan Teh on metabolism of CD8 Tcells in iron deficiency and why they love aspartate (+ @sarahdimeloe.bsky.social @lindavsinclair.bsky.social); & reviewing the strong influence of iron on immunity @joefrost.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Special issue Immunometabolism and Beyond: from Liver to Brain!
European Journal of Immunology
Article types: reviews and research articles
Submission deadline 1 November 2025
Thanks to Nadja, Matteo and Bin for this wonderful opportunity!
#immunometabolism #EJI #CRC1292 #CRC355 #CRC156 #FZI

🚨Last week's #immunometabolism findings
@biomednews.bsky.social 🔽🔽🔽

biomed.news/bims-imicid/...

Interesting paper:

Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells

Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells - Nature Communications Iron has been shown to be necessary for the activation and differentiation of CD8+ T cells. Here the authors investigate changes in CD8+ T cell metabolism in iron limiting conditions and find that asp...

Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells #immunometabolism
www.nature.com/articles/s41...

So cool to start the afternoon session with @plantophagy.bsky.social !! Here in the @autophagyuk and @UK_proteostasis meeting

Spectrum of Treg and self-reactive T cells: single cell perspectives from old friend HTLV-1 Summary. Despite extensive regulatory T cell (Treg) research, fundamental questions on in vivo dynamics remain to be answered. The current study aims to di

What if Tregs are not a separate lineage, but part of spontaneously activated T cells?
In this work, we integrate this idea with our recent findings: Adult T cell leukemia (ATL) is not 'Treg cancer', challenging the current concept of Treg as a distinct entity.🧵(1/4)
academic.oup.com/discovimmuno...

Aaaw, thanks Bob 😄. It was fun pulling it together!

Review @annualreviews.bsky.social @lindavsinclair.bsky.social @cantrell-lab.bsky.social
Protein Synthesis and Metabolism in T Cells
www.annualreviews.org/content/jour...

Our review on Protein Synthesis and Metabolism in T cells is out @annualreviews.bsky.social @cantrell-lab.bsky.social
Protein Synthesis and Metabolism in T Cells #proteomics #immunometabolism #Tcells
www.annualreviews.org/content/jour...

Very excited to be just a weekend away from this UK conference on neutrophil biology that we are hosting at Newcastle. It includes international keynotes but most important the majority of speakers are early career researchers. #immunology #inflammation #neutrophils #humandisease

ICYMI by First release - now in print @science.org

Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.

buff.ly/3DjNQ1e

By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al

#Immunosky #Immunometabolism

A functional single-cell metabolic survey identifies Elovl1 as a target to enhance CD8+ T cell fitness in solid tumours - Nature Metabolism Through a functional CRISPR/Cas9 screening, Pretto et al. identify Elovl1 as a target to improve antitumour immunity by remodelling T cell lipid metabolism.

www.nature.com/articles/s42...
Here’s the paper 😊

Disrupting cholesterol homeostasis in T cells boosts antitumour responses - Nature Metabolism A new study identifies a mechanism by which Elovl1 deletion disrupts the canonical feedback inhibition of cholesterol synthesis in T cells. By fundamentally rewiring cholesterol metabolism, Elovl1-dep...

A lovely News and Views on Samantha Pretto/Max Mazzone’s “ #Elov1 and #CD8s and #tumour paper “ - check it out! www.nature.com/articles/s42...

📢 A new episode of the podcast is out!

We chat with Dr. Luke O’Neill (@lukeanthonyoneill.bsky.social) at Trinity College Dublin (@tcddublin.bsky.social) about the metabolic regulation of immune cell function and the innate #ImmuneSystem.

🎧 Listen now: bit.ly/3QybMBq

Two weeks left to apply for a postdoc position with the Slack group! Please spread the word!

We're based in the Ashworth Laboratories, King's Buildings, University of Edinburgh. Photo shows the main staircase in the entrance to the Ashworth, stone steps from the 1920s, decorated with a series of bright, colurful banners depicting the science that's tackled in the building.

I'm very pleased to have two lab positions open this week, to join our team looking at immune regulation in infection and co-infection. We're especially interested in tissue-based immunity, cytokine regulation and immune metabolism. Join us! Postdoc (3y) and research technician (12mo) posts open.

Hallmarks and metabolic regulation of type 2 activated human lung macrophages Although human lung macrophages are heterogenous and play key roles during health and disease, the mechanisms that govern their activation and function are unclear, particularly in type 2 settings. Ou...

Very happy to share our new preprint on hallmarks of human #lung #macrophage activation by type 2 cytokines, and metabolic control of this process 🙂. #immunometabolism #ImmunoSky 🧪 @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social www.biorxiv.org/content/10.1...

Thanks Karen 🤗

Thanks Hal 😊😊

Thanks Bob, glad you enjoyed it 🤩

Thread is out now too Mary ;-)

Okey dokey here goes! First real post - please reshare if appropriate 🙏

🔔We’ve got two postdoc level positions opening in our lab! One wet lab, one computational🔔

We’re a scientifically diverse, friendly bunch working at the interface of mitochondrial biology, metabolism & cancer in Glasgow, UK.

*** www.immpres.co.uk *** correct link.

Oops! Naive cells have very HIGH autophagy flux, which is reduced on activation.
*typo 😂

Autophagy repression in effector T lymphocytes redefines paradigms in T cell biology - Nature Immunology Autophagy, thought to be boosted by T cell receptor or cytokine stimulation, took an unexpected turn in the findings of Sinclair et al. — it is suppressed in activated T cells, facilitating their effe...

14/14
Finally – this work was reviewed beautifully in the accompanying News and Views.
www.nature.com/articles/s41...
@natimmunol.bsky.social @natureportfolio.nature.com

13/n Much more is in the paper!
Thank you to ALL –> authors, NatImm team, and the constructive reviewers/review process that helped
elucidate many key features of this story.

We have uploaded the proteomics data to ImmPRes (www.immpres.co.uk)
Go and check out your favourite proteins!

12/n The proteins fuelled by autophagy in naïve CD8 Tcells included essential proteins for naïve cell homeostasis : eg KLF2 and CD62L

11/n Proteomics on naïve CD8 Tcells +/- VPS34 inhibition showed the predominant substrates are mitochondrial proteins.

In naïve CD8 T cells mitochondria are constantly pruned to remain healthy. Blocking autophagy results in accumulation of pro-apoptotic proteins eg BAK1 and BIM, and cell death.