Alessio Vagnoni

wow - this is a proper walk down memory lane! Thanks for the vital support over the years @nc3rs.bsky.social. It is always a pleasure working with you, I appreciate your genuine interest in what we do.

Global 3Rs Winners LEARN MORE / APPLY 2025 Award Winners ASIA-PACIFIC Bing Zhou, Ph.D., M.D. “Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11” Cell Metabolism Sha

Congratulations to @alessiovagnoni.bsky.social who has been announced as a recipient of this year’s AAALAC International Global 3Rs Award recognising his ongoing work in advancing the 3Rs: www.aaalac.org/awards/globa...

We have a postdoctoral position available in the lab europeandrosophilasociety.org/job/postdoct.... Get in touch if interested!

1/ 🚨 Our new paper is online in @nature.com! As its first author, I’m enthusiastic to finally share it with you all! 🎉 🧠 We discovered a mechanistic link between cellular energy metabolism and the control of the need to sleep 💤 👉 rdcu.be/ewwrA @oxforddpag.bsky.social @ox.ac.uk @medsci.ox.ac.uk 🧵 👇

Our BBSRC CircadiAgeing sLola project launches today with
@hughp.bsky.social @krasimiratsaneva.bsky.social @mino-belle.bsky.social @mbra3.bsky.social @alessiovagnoni.bsky.social studying clock excitability, circadian rhythms and healthy ageing
circadiageing.blogs.bristol.ac.uk

The CircadiAgeing project explores how disruptions in circadian rhythms, the natural 24-hour cycles of physiological and behavioural patterns, contribute to ageing and related health issues.
circadiageing.blogs.bristol.ac.uk

VFB works closely with the FlyBase team and we rely on their hard work to provide many of our features. Due to the current funding situation at FlyBase (flybase.org), we encourage our users to donate and help maintain this essential resource.

Our new paper in Neurobiology of Aging showing that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice:

www.sciencedirect.com/science/arti...

@dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social @uclqsion.bsky.social #aging

Gaza has been failed by silence and impunity Gaza is on the brink of famine. The Integrated Food Security Phase Classification, a multistakeholder global initiative aimed at enhancing food security and nutrition analysis, reports that the entire...

www.thelancet.com/journals/lan...

First map of human brain mitochondria is ‘groundbreaking’ achievement Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.

The brain’s energy landscape as a potential window into brain health
www.nature.com/articles/d41...

(study led by Martin Picard and Michel Thiebaut de Schotten)

Microtubule acetylation is a biomarker of cytoplasmic health during cellular senescence https://www.biorxiv.org/content/10.1101/2025.03.31.646469v1

Tracking spatiotemporal distribution of organelle contacts in vivo with SPLICS reporters - Cell Death & Disease Cell Death & Disease - Tracking spatiotemporal distribution of organelle contacts in vivo with SPLICS reporters

www.nature.com/articles/s41...
Fun collab with T.Calì&M.Brini, led by postdoc Lucia Barazzuol and supported by Tatiana Tykhonenko and PhD student Tia Griffiths @kingsioppn.bsky.social @wohlmicroscopy.bsky.social @nc3rs.bsky.social

Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease - Nature Cell Biology Chou et al. generate transdifferentiated human neurons from fibroblasts from young or aged individuals and patients with Alzheimer’s disease. Studies of endolysosomes and proteostasis suggest a role f...

Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease
www.nature.com/articles/s41...

Drosophila larval motor neurons labelled with GFP (green) showing activated ATF4 expression (magenta) due to knockdown of the mitochondrial complex I subunit NDUFS1 Two larger ridges of green vertically show green processes coming out from the centre with magenta cells along the central valley between the green in clusters as well as some along the green outer processes

Drosophila larval motor neurons labelled with GFP (green) showing activated ATF4 expression (magenta) due to knockdown of the mitochondrial complex I subunit NDUFS1 #FluorescenceFriday
Imaged by @batemanlab.bsky.social

Amyloid beta precursor protein contributes to brain aging and learning decline in short-lived turquoise killifish (Nothobranchius furzeri) Brain aging is a pivotal risk factor for many neurodegenerative diseases, yet its molecular and cellular mechanisms remain elusive. The amyloid-beta precursor protein (APP) is among the most studied p...

www.biorxiv.org/content/10.1...

Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites - Nature Communications Protein-mediated transport is implicated in trafficking fatty acids at contact sites of lipid droplets and mitochondria. Here, the authors use proteomics to catalogue the proteins at this contact site...

Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites
www.nature.com/articles/s41...

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.

Risdiplam for Prenatal Therapy of Spinal Muscular Atrophy | NEJM The alternate splicing small molecule risdiplam, administered to a fetus with spinal muscular atrophy, had an apparent ameliorating effect on the disorder through 30 months.

www.nejm.org/doi/10.1056/...

imAGEin Programme - Life

imAGEin: one-in-a-kind 2Y Erasmus Mundus Joint Master @euerasmusplus.bsky.social on the Biology of #ageing. shorturl.at/n4jsd Partners: @ucoimbra.bsky.social @sorbonne-universite.fr @univcotedazur.bsky.social @unisevilla.bsky.social @unicologne.bsky.social. 15 scholarships available to cover costs.

In our latest pre-print, we show that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice:

www.biorxiv.org/content/10.1...

Well done team! @dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social et al.

@uclqsion.bsky.social #aging

Do you want to hear the latest and greatest about the neuronal cytoskeleton? Join us in Chile next April for #NeuroCyto2025, organized by @monicamsousa.bsky.social, Kassandra Ori-McKenney and Tomás Falzone! Registration is open until March 5: neurocytoskeleton.com/2025/

I’m ultra excited about our preprints on mitochondrial pearling. In two concurrent collaborative studies with @wallaceucsf.bsky.social, we investigated its consequences on mtDNA nucleoids (led by @jclandoni.bsky.social) & its biophysical causes (led by @gavsturm.bsky.social). Funders HFSP, ERC, SNSF

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology

www.biorxiv.org/content/10.1...

NHS to begin world-first trial of AI tool to identify type 2 diabetes risk Exclusive: Two London hospital trusts to trial tool that can predict those at risk up to 13 years before condition develops

www.theguardian.com/society/2024...

Good use of hospital records, biobank data, and AI

Announcing award of our 5 year BBSRC sLola CircadiAgeing: clock excitability, circadian rhythms & healthy ageing grant with @hughp.bsky.social @MeganGJackson @mbra3.bsky.social @krasimiratsaneva.bsky.social @mino-belle.bsky.social @alessiovagnoni.bsky.social Edgar Buhl
bristol.ac.uk/news/2024/de...

Really excited to be part of the CircadiAgeing team @docfly.bsky.social @mbra3.bsky.social @krasimiratsaneva.bsky.social, H.Piggins, M.Belle @official-uom.bsky.social

BBSRC injects £20 million into long-term discovery research BBSRC is backing four major research projects to help pioneer critical advances in healthy ageing, drug discovery and sustainable agriculture.

Excited to be part of one of the BBSRC larger and longer grants with such a great team. Healthy circadian aging is healthy brain aging… @imperialmed.bsky.social

www.ukri.org/news/bbsrc-i...

The birth of fruit fly's central nervous system imaged with multicolor #adaptive #lightsheet microscopy. The microscope self-aligns to a signal that appears during imaging.

www.nature.com/articles/nbt...

Cellular ATP demand creates metabolically distinct subpopulations of mitochondria Nature - Mitochondria are able to maintain two competing metabolic pathways—oxidative phosphorylation and the reductive synthesis of proline and ornithine—by generating two...

Ye Olde endosymbiont never cease to surprise

rdcu.be/d222K