π§ New preprint: Neurodegeneration-associated proteinopathies are not confined to the brain, they can be detected in routine GI biopsies, years before symptom onset.
16.10.2025 09:19 β π 0 π 0 π¬ 0 π 0
Protein misfolding in the gastrointestinal tract predicts and prognosticates neurodegenerative disease years before symptom onset #NeuroDegeneration π§ͺπ§
http://medrxiv.org/cgi/content/short/2025.10.13.25337884v1
16.10.2025 07:02 β π 1 π 1 π¬ 0 π 0
Protein misfolding in the gastrointestinal tract predicts and prognosticates neurodegenerative disease years before symptom onset https://www.medrxiv.org/content/10.1101/2025.10.13.25337884v1
16.10.2025 04:58 β π 2 π 1 π¬ 0 π 1
#Medskyπ§ͺ #neurosky #immunosky Studies are investigating a link between #proteinmisfolding in GIT & the development of #neurodegenerativediseases like #Parkinson & #Alzheimer often years before symptoms appear.
16.10.2025 05:39 β π 6 π 1 π¬ 1 π 0
Brain Iron as a Surrogate Biomarker of Pathological TDP-43 Identifies Brain Region-Specific Signatures in Ageing, Alzheimer's Disease and Amyotrophic Lateral Sclerosis https://www.biorxiv.org/content/10.1101/2025.10.02.680028v1
04.10.2025 00:15 β π 2 π 1 π¬ 0 π 0
Prof. Jenna Gregory @uniofaberdeen.bsky.social
outlines some precision-prevention concepts for #MND
π€Detection>Before motor symptoms arise
π€Precision>Understanding individualβs risk factors & heterogenous disease manifestations
π€Prevention>Safe interventions & early triage to clinical trialsπ§΅3/3
14.03.2025 16:02 β π 1 π 0 π¬ 0 π 0
Unlike cancer, which is often diagnosed early in the community #MND is typically diagnosed in late stages in the outpatient setting. Prof. Jenna Gregory from @uniofaberdeen.bsky.social highlighted the need for early detection with point-of-care assays. π§΅2/3
14.03.2025 16:02 β π 1 π 0 π¬ 1 π 0
At LifeArc's recent 1st ever Translational Science Summit on MND & Rare Dementias, Clinical Prof. Jenna Gregory
from @uniofaberdeen.bsky.social set out a vision for early diagnosis & prevention in #MND #ALS through learning from cancer, early detection tools, & a focus on prevention π§΅1/3
14.03.2025 16:02 β π 2 π 0 π¬ 1 π 0
feeds: biorxiv, medrxiv, arxiv.q-bio, arxiv.cs, arxiv.math, Research Square
regex: "(neurodegeneration|Alzheimer|Parkinson's|Huntington|amyloid lateral sclerosis|multiple sclerosis|Apoe4)"
All contacts to @willmacnair :)
"Not all those who wander are lost" JR Tolkien
#Clinicalresearcher #DrugDevelopment
#Clinicaltrials & Registration
π§¬π¬πππ¦ 𧫠π
Melbourne π¦πΊ Oxford π¬π§& π΄σ §σ ’σ ³σ £σ ΄σ Ώ #MedSkyπ§ͺ
π₯ Group Leader & Wellcome Career Development Fellow @ UCL | π₯ Honorary Consultant Neurologist at NHNN | π¬ Researching Parkinsonβs π§¬, neurodegeneration π§ , ageing β³, lysosomes π«§π using Drosophila πͺ° | π¬ Thoughts my own and random π²
Neurobiology - Sapienza University | EMBL
Interests in:
- Visual Systems Neuroscience;
- Neurophysiology and functional neuroanatomy of the Visuomotor System;
- Computational Neuroscience (Modelling & Artificial Neural Networks).
Auditory neuroscientist at University of Sheffield, interested in understanding how the brain supports auditory perception. Opinions my own.
https://www.sheffield.ac.uk/hearing/wood-lab
In memory of my Dad, a burly #Lancashire dairy farmer, I'm raising awareness of motor neuron disease....
#MND #MoreNeedsDoing!
Championing #Lancashire!
UK DRI Group leader at the University of Edinburgh. Neuroscientist using iPSC, organoids & genetics to understand Tauopathy and other dementias.
Instagram: @bowleslab
She/Her
Aussie #MND #ALS Warrior, now living in Scotland. Retired Maritime/Shipping lawyer (non-practising - Australia, England/Wales & Scotland).
Post doc in the Patani Lab at the National University of Singapore, interested in the role of glia in motor neuron disease using iPSC models
Bhinge Lab @lsiexeter.bsky.social works on "RNA Dysregulation in Neurodegeneration" | Passionate about curing Neurodegenerative Diseases | We love neurons, stem cells, animals
https://www.bhingelab.com/
https://experts.exeter.ac.uk/26305-akshay-bhinge
Motor Neurone Disease Australia is the peak body for the MND community in Australia. We have built & sustained Australian MND research for 40 yrs and partner with other Australian and international MND/ALS organisations.
The UKβs leading research institute transforming the lives of people affected by neurodegenerative conditions. Principally funded by the Medical Research Council.
Postdoctoral Research Associate in the Brain Infection and Inflammation Group at the University of Liverpool. iPSC and electrophysiology enthusiast. Mum, roller derby skater πΌ, weightlifterποΈ#encephalitis
Join us in bringing AI to the fight against ALS. Learn more about the Longitude Prize on ALS at our website (https://bit.ly/457a8zo), and follow us for updates.
PhD candidate working on SMA π§¬
University of Edinburgh
Lyndsay Murray Lab
Scientific Editorial Team @braincommunications
