Simone Papa

🦐 Parhyale hawaiensis for #3DSunday!

A rising crustacean model for evo-devo, regeneration & limb development. microCT imaging reveals its intricate 3D body plan segment by segment, limb by limb.
A powerful system beyond insects! 🔬🏛️ (by Brandy Freitas)
#3DImaging #EvoDevo #MarineBiology

✨ #FluorescenceFriday meets 3D Spatial Biology! Using computational H&E on our 3Di platform, we map NSCLC biopsies from tissue to subcellular scale, revealing hidden TLS 200 µm deep(by Alpenglow Biosciences)

🚀 3D imaging = unbiased counts + richer immune insights.
#SpatialBiology #3DImaging

👁️ New research from the Rompani & Asari labs @embl.org Rome challenges old views of the pupil.

Beyond reacting to light or emotion, it may actively shape vision, integrating input from both eyes and modulating the visual pathway. #Neuroscience #Vision #EMBL

www.embl.org/news/science...

Asked my favorite marker for Tau pathology? 😉 I say at least 10! From early oligomers to late fibrillary tangles, each tells a story (by Danielle Beckman)

In this recent study with CNPRC & Takeda, they mapped Tau progression in monkeys, markers also fit human and mouse tissue
#Neuroscience #Tau

Design of a potent interleukin-21 mimic for cancer immunotherapy A de novo IL-21 mimic, 21h10, exhibits improved stability and potent antitumor activity in vivo compared with native IL-21.

Scientists have designed an interleukin-21 mimic with increased stability and capacity to induce more potent antitumor activity than the native protein, which could inform improved immunotherapies.

www.science.org/doi/10.1126/...

Creative Minds, Younger Brains: Engaging in music, dance, painting or even (some) gaming is linked to delayed brain aging.
www.nature.com/articles/s41...

🌻 The thymeleaf speedwell (Veronica serpyllifolia) self-pollinates: no bees, no wind, just pollen transfer within one bloom. 🌿

A survival backup in harsh spots, ensuring seeds, though at the cost of diversity. (By Nicolas Hubacz)

#Botany #Nature #Resilience

Jane Goodall, known for her pioneering work with chimpanzees, has passed away aged 91
#JaneGoodall #science
www.nature.com/articles/d41...

Here's a reminder on hashtag #InternationalCoffeeDay: It's OK to take a (coffee) break. ☕

"It’s ... helpful to have a venue to share the day-to-day ups and downs of life as a grad student," a hashtag
#PhD student wrote in this 2019 Working Life.

www.science.org/doi/10.1126/...

🧠✨ Dive into mouse brain connections!

Reconstructed neurons from the thalamus project across the cortex, revealed by fluorescent labeling and advanced ExA-SPIM microscope (by Allen Institute)

#brain #connections

🦠 Inside mouse brain tumor cells: actin (💜) shapes movement mitochondria (💚) fuel survival.

Visualizing both reveals how structure & energy intertwine, keys to tackling aggressive brain cancers.
(by Nicolas Hubacz)
Credit to Dr. Eric Vitriol and Nikon Small World in Motion!

#tumorcells #brain

Last week I joined the “Is AI intelligence?” conference at Sapienza University of Rome with BrainJuiceClub, leading a workshop on dialogue between Neuroscience and AI.

Now we look ahead: BrAIns 2025 on Oct 24, with keynotes, posters & short talks. Join us to share ideas and perspectives! 🧠
#BrAIns

Thank you for sharing this perspective. The Dupret (2013) study is indeed a seminal reference, elegantly bridging circuit mechanisms with our own experience of flexible mental maps. It’s fascinating to see how more recent work, like Valero et al., continues to refine and expand that narrative.

Phosphorylation of the protein Tau is an hallmark of AD, and here it is in our organoid model.
Neurons are labeled in red, phospho-Tau in green (making the overlap yellow) (dr. Joao Pereira - University of Alabama at Birmingham)

Wonderful work by PhD student Maggie Ireland!
#neuroscience #Tau

Inhibitory interneurons may help encode the brain’s internal representation of space.

www.science.org/doi/10.1126/...

Excited to join the first Brainstorming Juice after summer break! 🧠🍹
📍 Tomo, Via degli Etruschi 4
🕕 Thu, Sept 25 – 18:00
Topic: Neuroscience & AI. Come share ideas, projects & feedback! ✨

Open science is not just for researchers. Artist @kindracrick.com created these beautiful neuron portraits with inspiration from Ramón y Cajal's drawings and reference images from our Cell Types Database.

#OpenScienceWeek

Physics laureate Giorgio Parisi speaks about the importance of self-confidence and believing in yourself.

Parisi was awarded the 2021 physics prize for discovering hidden patterns in disordered complex materials.
(By TheNobelPrize)
www.nobelprize.org/prizes/physi...

NEW TOOLKIT release from EBRAINS researchers!

The Virtual Brain Inference #VBI #toolkit has been launched: an open-source software available on the EBRAINS platform.

VBI matches #virtualbrain models with real neuroimaging data (EEG, MEG, fMRI)

www.ebrains.eu/news-and-eve...

I’m happy to share that I’ll be speaking at the workshop A Shared Language for Intelligence: Why Communication Between Neuroscience and AI Is Key.

Looking forward to contributing to the discussion and to connecting with fellow researchers and professionals. Don’t miss it on September 26th!"
#neuro

📅 Il 24 ottobre torna brAIns, la terza edizione dell’evento che esplora il legame tra intelligenza biologica e artificiale.

📅 On October 24, brAIns returns with its third edition, the BrainJuice event exploring the connection between biological and artificial intelligence.

#BrAIns2025

Together with Andre Geim, Konstantin Novoselov first produced the material graphene in 2004.

It was one of their 'Friday night experiments', a time when they would explore things they didn't have time to work on during their research projects. (by NobelPrize)

The Brain Merges Sight And Sound For Faster, Smarter Decisions - Neuroscience News New research reveals how the brain merges visual and auditory information to make quicker, more accurate decisions.

New research shows your brain merges sight & sound in the motor system, turning parallel sensory processing into faster, smarter decisions.

neurosciencenews.com/audio-visual...

“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”

Genes shape brain networks, but do genes linked to the same disorder converge on shared circuits?
www.medrxiv.org/content/10.1...

How Stress Types Differently Impact Brain and Behavior - Neuroscience News A new study in rats reveals that acute stress provokes anxiety-like behaviors, especially in males, while chronic stress is more strongly tied to depressive symptoms.

Acute stress sparks anxiety, while chronic stress drives depression and men and women respond differently. New research shows how stress duration and sex shape mental health risks, pointing to more personalized treatment strategies.
neurosciencenews.com/stress-style...

On 20 August 1955, Dorothy Crowfoot Hodgkin and her colleagues published the final structure of vitamin B12. Vitamin B12 has the most complex structure of all vitamins.
(By NobelPrize)

Photo: Vitamin B12 structure. Chemical Heritage Foundation and official Nobel portrait of Dorothy Hodgkin

Highly Sensitive People Face Greater Mental Health Risks - Neuroscience News A large-scale meta-analysis of 33 studies has shown that highly sensitive individuals are more prone to common mental health problems, including depression, anxiety, PTSD, and avoidant personality dis...

A new meta-analysis finds highly sensitive people are more likely to face anxiety, depression, and PTSD, but also respond better to therapies like mindfulness. Sensitivity may be the hidden key to personalized mental health care.
#neuroscience #PTSD #mentalhealth
neurosciencenews.com/mental-healt...

🧠 Psychiatric Pharmacology at a Glance 💊

📊 While the diagram looks overwhelming, it reflects the complexity of psychiatry itself: every treatment is a balancing act between neurotransmitter pathways, clinical benefit, and side effects (by Nicolas Hubacz)
#Pharmacology #Biotech #Psychiatry

What is a human brain cell but not a neuron?
It sounds like a riddle, but our brains are full of other, lesser-known cells besides the textbook-famous electrical-signal-conducting neurons.
IMAGE: A delicate type of brain cell known as an astrocyte (by Allen Institute)
#SciShots

Study on microvascular contributions to age-related white matter loss has been published in Nature Neuroscience.

In this work, they identify rare, deep-reaching venules called principal cortical venules (PCVs)

www.nature.com/articles/s41...