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Ben Clarke

@benclarkeuk.bsky.social

Post doc in the Patani Lab at the Francis Crick Institute and University College London, interested in the role of glia in motor neuron disease using iPSC models

320 Followers  |  455 Following  |  2 Posts  |  Joined: 13.11.2024  |  1.4345

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#GliaPapers #GliaSpecial2025 REVIEW

Stanislaw Majewski, โ€ฆ, @benclarkeuk.bsky.social, Rickie Patani
www.crick.ac.uk/research/fin...

Towards an integrated approach for understanding glia in Amyotrophic Lateral Sclerosis
onlinelibrary.wiley.com/doi/10.1002/...

31.01.2025 17:35 โ€” ๐Ÿ‘ 4    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
Human VCP mutant ALS/FTDย microglia display immune and lysosomal phenotypes independently of GPNMB - Molecular Neurodegeneration Background Microglia play crucial roles in maintaining neuronal homeostasis but have been implicated in contributing to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, ...

Excited to share our new paper!Using iPSC-microglia with VCP mutations, we uncovered immune & lysosomal dysfunction. Secretome transfer revealed JAK-STAT activation in neurons & astrocytes. A big team effort over many years!

molecularneurodegeneration.biomedcentral.com/articles/10....

03.12.2024 17:51 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

This is great thanks! Would love to be added

16.11.2024 22:55 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

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