@morganlab-saarland.bsky.social
We love redox biology!
We are looking for a new colleague in the biology department at Saarland University!
We are looking for excellent Cell Biologists / Cell Physiologists for a W2 tenure track W3 professorship in 'Dynamics of Biological Systems'.
Please share!
jobs.zeit.de/jobs/w2-prof...
8/ 8/ The work now begins to understand the functional implications of peroxiredoxin heterooligomerisation and its implications for our current view of these fascinating proteins.
11.03.2025 09:09 — 👍 4 🔁 2 💬 0 📌 0
With Armindo Salvador, we determined that it is possible to form as many as 120 distinct heterodecameric complexes with two monomeric components.
11.03.2025 09:09 — 👍 3 🔁 0 💬 0 📌 0
6/ With @riemerlab.bsky.social we could also show the presence of PRDX1-PRDX2 heterooligomers in HEK293T cells.
11.03.2025 09:06 — 👍 3 🔁 0 💬 0 📌 0
5/ Heterooligomerisation is inducible in response to oxidative challenge in yeast and stabilises Tsa1 as a Tsa1-Tsa2 heterodecameric complex.
11.03.2025 09:06 — 👍 1 🔁 0 💬 0 📌 0
4/ With the Messens lab, we used negative stain EM to visualise heterooligomers and show that heterooligomerisation strongly affects dimer-decamer equilbrium.
11.03.2025 09:05 — 👍 1 🔁 1 💬 0 📌 0
3/ Long considered to only form homooligomeric complexes, we find that pairs of peroxiredoxins from human, yeast, plant and parasite readily assemble into heterodimers and heterodecamers.
11.03.2025 09:03 — 👍 1 🔁 0 💬 0 📌 02/ We also had the pleasure to work with @riemerlab.bsky.social @herrmannlab.bsky.social, Timo Mühlhaus lab, Ana Tomas lab and Armindo Salvador on this exciting project
11.03.2025 09:02 — 👍 3 🔁 0 💬 0 📌 0
Our first post on Bluesky!
1/ We are excited to share our latest work, showing that heterooligomerisation drives structural plasticity of Prx1-type peroxiredoxins.
www.biorxiv.org/content/10.1...
Another fantastic collaboration with the Marcel Deponte lab and Joris Messens lab!
