Chaitanya Dingare

Congratulations!

1🧵
Excited to share my first PhD paper, published in @dev-journal.bsky.social
What if fish gills —often overlook —hold secrets about development, patterning, and function?
We uncovered how early patterning shapes adult gill architecture.
journals.biologists.com/dev/article/...

#DevBio #Zebrafish

New preprint from the Lecaudey lab by first authors Anna Mertens and Nicola Moratscheck, with the help of other former members including @chaitanyadingare.bsky.social uncovering the role of integrin-laminin interactions during epithelial collective cell migration!

Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling Enhanced STAT3 activation combined with TGF-β inhibition reprograms human PSCs into cells specifying all early embryonic lineages. Upon 3D suspension culture, these cells self-organize within 6 days i...

(1/8) Very Happy to share our lab’s 3D post-implantation human embryo model, made via signalling reprograming!
🙌 Huge thanks to the entire team and our collaborators, special shout-out to @cc0447.bsky.social (led the work) and @jinjin-0101.bsky.social (comp. analysis).
www.cell.com/cell-stem-ce...

This is a rigorous piece of work, completed with help of current @vlecaudey.bsky.social lab members.

I combined the genetics with live imaging approaches to delineate how hippo pathway and its regulators control the cell number. I have generated a few essential tools including the zebrafish specific yap1 antibody (works really well).

I have used the zebrafish lateral line primordium as a model. Reason - it contains only 100-120 cells to begin with so much easier to follow the mechanisms that controls the cell number.

Vgll4 Proteins limit Organ Size in Zebrafish through Yap1-Dependent and -Independent Mechanisms Precise control of organ size is crucial during development and homeostasis. Dysregulation of the underlying mechanisms can result in organ malformation and tumorigenesis. Although the Hippo signaling...

www.biorxiv.org/content/10.1... late post! Parts of my PhD thesis are now in a preprint. Just imagine if each cell of your organs decides to undergo some extra divisions while being formed, how would they look and what prevents that from happening? This is exactly what I have shown in my work.

Patterned integrin-laminin adhesion coordinates epithelial collective cell migration https://www.biorxiv.org/content/10.1101/2025.09.12.675859v1

@vlecaudey.bsky.social !

Congratulations!

Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social

Nerve-to-cancer transfer of mitochondria during cancer metastasis
www.nature.com/articles/s41...

GATA6 Mediates Endoderm and Mesoderm Progenitor Fate Driven by WNT and NODAL Signaling https://www.biorxiv.org/content/10.1101/2025.06.20.660704v1

An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning https://www.biorxiv.org/content/10.1101/2025.06.17.660116v1

It’s out! 🥳

www.science.org/doi/10.1126/...

The weekly Metabolites-driven PTMs focusing on cancer Biomed News is out ☺️ biomed.news/bims-prolim/...

Congratulations! The images look amazing!

If you’ve ever wondered how those intricate gill structures emerge—and how gills develop throughout a zebrafish’s lifespan—check out my new preprint!
We dive into the development of gills and their vasculature in detail.
Huge thanks to @vlecaudey.bsky.social for the support🐟

#zebrafish #microscopy

New preprint from the lab! Beautiful work by @mathpreu.bsky.social, who delved into the early development of gills and their intricate vasculature. Thanks to the Clusterproject ENABLE and @goetheuni.bsky.social for the funding! www.biorxiv.org/content/10.1...

Metabolites are not genes

COMMENT | KS Li, X Su & T Huan (Rutgers U, UBC):

Metabolites are not genes — avoiding the misuse of pathway analysis in #metabolomics.

https://bit.ly/4kIGbtI ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab

A lipid metabolism defect is an underlying contributor to Diamond Blackfan anemia syndrome https://www.biorxiv.org/content/10.1101/2025.05.22.654334v1

Signaling and Mechanics influence the number and size of epithelial rosettes in the migrating zebrafish Posterior Lateral Line primordium https://www.biorxiv.org/content/10.1101/2025.05.17.650326v1

Experimental embryology postdoc available in my lab at the @biology.ox.ac.uk @ox.ac.uk working on the evolution of vertebral counts. Reach out if you’re passionate about EvoDevo, enjoy lab work and microscopy and are into or could get into cichlid fishes. Deadline on the 16th June. Please share!

Interesting work on #morphogen (BMP4, Wnt8) mobility and HSPGs in Xenopus🐸

“We propose a model in which Yap1, together with Tead proteins, ensures that the [posterior lateral line primordium] contains a sufficient number of cells before migration begins.”

New work from @vlecaudey.bsky.social 👩‍🔬

Vgll4 Proteins limit Organ Size in Zebrafish through Yap1-Dependent and -Independent Mechanisms https://www.biorxiv.org/content/10.1101/2025.05.08.652796v1

New preprint from the lab!! Project was initiated by @chaitanyadingare.bsky.social and continued by Alicia Lardennois with quite some people involved on the way 🤗

Two transcriptional modules that control mammalian #gastrulation that are functionally linked through their GRNs www.biorxiv.org/content/10.1... and paced by interactions between Wnt and Nodal signalling
Great collaboration with S Arnold and K McDole's labs #gastruloids

Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...