Irina Dudanova

snRNA-seq of Huntington′s disease mice reveals vulnerability profiles of cortical cell types A common feature of neurodegeneration is selective vulnerability, where certain neurons succumb to disease, while others remain spared. The molecular underpinnings of these differences remain elusive....

New preprint from the lab by Dennis Feigenbutz et al.: Using #snRNA-seq, we explore vulnerability profiles of cortical cell types in #HuntingtonsDisease mice and identify ER-phagy as a new pathway in HD pathogenesis.

www.biorxiv.org/content/10.1...

Job Alert! The Institute for Neuro- and Behavioural Biology at the Faculty of Biology @uni-muenster.de invites applications for a Full Professorship (W3) in “Systems Neuroscience” - Highly attractive research environment at the Multiscale Imaging Center. Apply by January 5th. See shorturl.at/VczFp

Postdoc Research Group Douglass Our Group Our newly established research group at ISTA is seeking a postdoctoral researcher to work on an ERC-funded project- HypoAdapt. We study how the brain controls bodily responses to environm...

We are hiring a postdoc to work @istaresearch.bsky.social on an @erc.europa.eu funded project, investigating the control of behavior and physiology by the hypothalamus. Please apply and share! ist.ac.at/en/job/postd...

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Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...

Congratulations to Cole Sitron et al. from Ulrich Hartl's group @mpibiochem.bsky.social on this beautiful study exploring the interaction of α-synuclein aggregates with the ESCRT-III complex, now out in @cp-molcell.bsky.social - it was a pleasure to contribute to the project.

Trilled to share our new work🥳We show that age-related hyperactivation of the EPS8/RAC signaling pathway drives protein aggregation and neurodegeneration — hallmarks of Huntington’s disease and ALS. #proteostasis #aging #neurodegenerativediseases

AutoGaitA: A versatile quantitative framework for kinematic analyses across species, perturbations and behaviours Individual behaviours require the nervous system to execute specialised motor programs, each characterised by unique patterns of coordinated movements across body parts. Deep learning approaches for b...

New lab preprint: Leveraging the updated AutoGaitA toolbox, we revealed distinct species-specific mechanisms to generate propulsion during walking and the conserved pattern of age-related propulsive decline from flies to humans. www.biorxiv.org/content/10.1...

Apply now for a fully funded #PhD position at the Cologne Graduate School of Ageing Research and become part of our vibrant #AgingResearch commmuny.
🗓️ Deadline: November 3, 2025.
ℹ️ More info: www.ageing-grad-school.de
📣 Spread the news!

Postdoc Position (f/m/x) We are looking to support our rapidly growing team as soon as possible:

We have a 4-year postdoc position open in our Research Unit on proteostasis!
The project explores inter-tissue regulation using advanced proteomics approaches.
Collaborative & interdisciplinary environment. More details & application here:
jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...

New work from our lab;)

🚨 Scholarship Alert! 🚨 Pursue your Master studies in Biology or Biochemistry with our #CGA Master Fellowship programme. 🧬👩🏽‍🔬💰 Explore ageing research at the Cologne Ageing Campus! Apply by July 15! 📅 🔗 Learn more: www.ageing-grad-school.de/master/maste...

Delighted to be part of the new Research Unit on Organismal Proteostasis.
Thanks to @thevilchezlab.bsky.social for all the hard work on putting together this consortium, and to the #DFG for funding our research!

Happy to share our new preprint, where we find that anle138b reduces Huntingtin inclusions and improves disease phenotypes in #Huntington’sDisease models, showing its potential as an HD treatment.
Great work by Miguel Padilha and several wonderful collaborators including thevilchezlab.bsky.social

Mitochondria serve as a Holdout Compartment for Aggregation-Prone Proteins hindering Efficient Ubiquitin-Dependent Degradation The accumulation of protein aggregates has been causatively linked to the pathogenesis of neurodegenerative diseases. In this study, we have conducted a genome-wide CRISPR-Cas9 screen to identify cell...

Mitochondria a safe haven for aggregation-prone proteins? #neurodegeneration. #Parkinson. Find our latest manuscript in @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

Interested in the molecular mechanisms of neurodegeneration?
📢 We are looking for a PhD student interested in studying the role of TDP-43 in genome stability and the DNA damage response!
Apply via this fantastic PhD Programme until April 3 👇

Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington′s Disease mice Huntington′s disease (HD) is a devastating movement disorder without a current cure. Although the monogenic basis of HD is well-defined, the complex downstream effects that underlie behavioral symptom...

Our new paper shows that targeted stimulation of a subtype of cortical inhibitory neurons can ameliorate motor deficits in Huntington’s disease mice. A great collab with @irinadudanova.bsky.social www.biorxiv.org/content/10.1...

Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington′s Disease mice Huntington′s disease (HD) is a devastating movement disorder without a current cure. Although the monogenic basis of HD is well-defined, the complex downstream effects that underlie behavioral symptom...

How do different cortical neuron types contribute to circuit dysfunction in #Huntington’s disease?

Check out our new collaborative study with @takakikomiyama.bsky.social, spearheaded by Sonja Blumenstock, now out as a preprint.

www.biorxiv.org/content/10.1...