🔬🧫🧬 How does gVasc use your samples and data for SCAD research? Swipe to see more information, key questions, and future directions ➡️ #SCAD #hearthealth #heartresearch #scadalliance #genetics #scadgenetics #womenshealth @scadalliance.bsky.social @pnatarajanmd.bsky.social @markelindsay.bsky.social
What is spontaneous coronary artery dissection (SCAD)? ♥️💬 Watch as Drs. Mark Lindsay, Tiffany Bellomo, and Pradeep Natarajan share information about this condition.
gvascstudy.org
#SCAD #genetics #scadgenetics @scadalliance.bsky.social @markelindsay.bsky.social @pnatarajanmd.bsky.social
Excited to share that I’m launching a Computational Genetics Lab spanning MGB Personalized Medicine, Cardiovascular Research Center at MGH, @harvardmed.bsky.social, and @broadinstitute.org. Our research focuses on the genetics of common diseases, with a particular emphasis on cardiovascular disease.
How do you join the gVasc Research Study? Visit gvascstudy.org 💻 and follow these easy steps! Complete a few short surveys about your health and receive the saliva kit in the mail 📝 📦 ❤️ #scad #heartresearch #scadalliance @scadalliance.bsky.social @pnatarajanmd.bsky.social @markelindsay.bsky.social
In the Summer we usually slow down… 🏖️ but here are some Fast Facts ⏱️🗒️ about spontaneous coronary artery dissection (SCAD). Visit gvascstudy.org to learn more about the gVasc study today🫀 #SCAD #heartresearch #cardiology @scadalliance.bsky.social @markelindsay.bsky.social @pnatarajanmd.bsky.social
Meet the Team! 🩺 gVasc investigators have extensive experience in cardiovascular disease and genetics🫀🧬 They bring together their expertise to uncover the genetic underpinnings of SCAD 🔍 gvascstudy.org #SCAD #cardiology @scadalliance.bsky.social @markelindsay.bsky.social @pnatarajanmd.bsky.social
gVasc is a research study trying to find out if there are genetic factors behind why SCAD happens🫀Click the link in our bio or head to gvascstudy.org to learn more about our study and to participate! #gvasc #SCAD #research #heart #hearthealth #heartresearch #scadalliance @scadalliance.bsky.social
🗓️ At #CSANZ2025? JAMA Associate Editors @rohankhera.bsky.social, MD, MS and @pnatarajanmd.bsky.social, MD, MMSc, will be at Plaza 4 today, Saturday, August 16 from 3 PM to 3:30 PM.
➡️ Stop by to ask questions
➡️ Learn about publishing opportunities
@cardiacsociety.bsky.social
Our study led by T. Bellomo and with @aniruddhpatelmd.bsky.social describes the relationship between lipoprotein(a) and incident & progressive extracoronary atherosclerotic vascular disease www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social
@broadinstitute.org @mgbresearch.bsky.social
New polygenic risk score for obesity predicts response with weight loss across 2 lifestyle intervention RCTs nature.com/articles/s41... @natureportfolio.nature.com
My comments in @nytimes.com nytimes.com/2025/07/21/h...
Should I tell anyone that I suspect misconduct in a paper I’m reviewing?
So important and with more ECRs reviewing this guidance is very welcome.
Things to keep in mind:
- Extend the benefit of the doubt
- Talk to the editor
- Check your tone
- Balance your responsibilities and your limits
Delighted to collaborate on this work led by @kellybolton.bsky.social describing how germline genetic variation influences the trajectory of clonal hematopoiesis to hematologic malignancy www.nature.com/articles/s41... @natureportfolio.nature.com @broadinstitute.org @mgbresearch.bsky.social
An abs risk generalizable risk calculator is challenging. Led by @somijemmacho.bsky.social, evaluating AHA PREVENT across 4 academic health systems, we found similar discrimination but variable calibration. A universal abs risk threshold may not suitably guide www.sciencedirect.com/science/arti...
Thrilled that our work on integrating genetic, contemporary and traditional risk factors into acute MI models has been published in
@CirculationGenomeandPrecisionMedicine @ahascience.bsky.social !!
Are genetic and contemporary risk factors as powerful as traditional RFs?
#CardioSky #cvPrev
Our study led by @romitb.bsky.social & C. Marnell shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are:
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...
Check out this PRS (www.pgscatalog.org/publication/...) and more in the latest PGS Catalog data release! Thanks to @pnatarajanmd.bsky.social & co for submitting their scores! See www.pgscatalog.org/submit for information about how to share your work!
Delighted to write this viewpoint with C. Tcheandjieu & C. Robinson on gleaning and translating genomic insights across communities www.ahajournals.org/doi/10.1161/... @ahascience.bsky.social @ahajournals.bsky.social
Our study led by A. Flores & with @aniruddhpatelmd.bsky.social describes a new peripheral artery disease PRS. Predictive capability for incident PAD is comparable to CKD & DM2. Among those with PAD, it also associates with major adv limb events jamanetwork.com/journals/jam... @jama.com #JAMACardio
📣 Psychological & behavioural considerations for integrating polygenic risk scores for disease into clinical practice www.nature.com/articles/s41...
Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms
tl;dr 👉 There's little/no evidence for this
Very excited to Chair this webinar on Cardiovascular Health May 21 7:30-8:30p ET hosted by @indiaspora.bsky.social with Opening Remarks from Vivek Murthy.
Register us02web.zoom.us/meeting/regi...
@drmarthagulati.bsky.social
@mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
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Among N=2530 w HeFH or ASCVD on max tolerated LLT with insufficiently low LDL-C (mean 98mg/dl), obicetrapib (CETPi) 10mg po daily v placebo led to 33% lower LDL-C at 3mo www.nejm.org/doi/full/10.... @nejm.org #EAS2025
A cross-ancestry integrated (clinical + genetic) coronary artery disease risk score outperforms the Pooled Cohort Equations alone for CAD risk prediction across 4 cohorts www.nature.com/articles/s44...
The most math equations written on a whiteboard by a clinician I've seen - yet amazingly well delivered to a broad audience!
S. Urbut's talk @broadinstitute.org A Practical Primer on Bayesian Statistics youtube.com/watch?v=jcFS...
@mgbresearch.bsky.social @harvardmed.bsky.social
Great paper on the intrinsic link between LDL and diabetes risk from @pnatarajanmd.bsky.social @skoyama.bsky.social @somijemmacho.bsky.social and colleagues:
jamanetwork.com/journals/jam...
Out today in AJHG, this work from my (recently graduated) student Teng Heng on recessive effects in 44k British South Asians from the Genes & Health project @genesandhealth.bsky.social . She found 185 independent hits of which >40% were novel. Worth looking for these in your own cohorts!
The OurHealth Study – Discovering the Causes Behind High Rates of Cardiovascular Disease and Diabetes in South Asians www.indiaspora.org/the-ourhealt... @indiaspora.bsky.social
Please sign up and share! ourhealthstudy.org
@romitb.bsky.social
Our study led by A. Shankar shows that genotype-phenotype discordance of LDL-C (stronger polygenic predisposition to hypercholesterolemia for a given LDL-C) stratifies CAD risk - esp in normocholesterolemia. www.sciencedirect.com/science/arti... @jaccjournals.bsky.social #JACCADv
Agreed - terrific collaboration with a terrific team!
Had a great time working on this project - so thrilled to see this work finally out now!!
