Labβs 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) donβt menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
10.10.2025 13:26 β π 281 π 86 π¬ 17 π 7
β¨If Monet studied mouse ovaries π¨ Stromal cells π Follicular cells π΅ and Fatty Cells π‘. Together, they reveal the cellular architecture and functional zones of the ovary π¬ Image provided by @shmimberly.bsky.social π§ͺ #FluorescenceFriday #ReproductiveBiology
22.08.2025 16:35 β π 78 π 15 π¬ 0 π 3
I'm so sorry Anders π€―
21.08.2025 14:09 β π 1 π 0 π¬ 0 π 0
H3K4me3 amplifies transcription at intergenic active regulatory elements
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...
20.08.2025 01:28 β π 83 π 33 π¬ 3 π 1
A world of possibilities contained in the ovary :)
08.08.2025 20:35 β π 1 π 0 π¬ 0 π 0
One of our favorite ovary images
08.08.2025 18:37 β π 7 π 0 π¬ 1 π 0
Postdoctoral Fellow, Hattie Chung Lab (Yale School of Medicine)
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
Our lab at Yale @yalemedicine.bsky.social seeks #postdocs with in vivo expertise to pioneer research at the intersection of tissue remodeling & aging. Work with us to uncover immunological & vascular drivers of ovarian aging, applying single-cell, spatial omics, and ML! jobrxiv.org/job/yale-uni...
08.08.2025 18:05 β π 10 π 8 π¬ 1 π 0
Thank you Jenn!!
01.08.2025 19:27 β π 0 π 0 π¬ 0 π 0
Thank you Haiqi!
01.08.2025 00:47 β π 1 π 0 π¬ 0 π 0
Being Too Helpful At Work Can Hurt Your CareerβHereβs How To Say No
Women are more likely to take on behind-the-scenes duties at workβextra tasks like onboarding or event planningβand it's hurting their careers. Here's how to say no.
In a study of professors, women got 378 new work requests over 4 weeks vs 118 for men. Women spent more time on service, advising & teaching; men on research. Orgs should track who is taking extra duties & ensure they are rewarded and distributed fairly. www.forbes.com/sites/kimels...
07.07.2025 20:03 β π 1506 π 598 π¬ 31 π 127
Microvascular obstruction is known to be a #LongCovid feature. Now a potential mechanism found for the obstruction induced by death of endothelial cells->sticky red blood cells. Which wouldn't respond to blood thinners or anti-platelet Rx
www.nature.com/articles/d41...
www.nature.com/articles/s41...
04.06.2025 19:38 β π 382 π 143 π¬ 25 π 18
Our ability to accurately determine an individual's risk for heart and vascular disease is getting transformed
βNew A.I. transformer model
www.thelancet.com/journals/lan...
βMeta-prediction
www.nature.com/articles/s41...
02.06.2025 20:21 β π 93 π 18 π¬ 3 π 2
Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature
The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...
Out @nature.com: Clonal tracing with somatic epimutations
𧬠Single cell methylome encodes cell state & clonal identity
π¨ EPI-Clone reads out both (+mutations, +RNA) at scale
π©Έ Clonal expansions of HSCs are universal from age 50, not driven by CH mutations
doi.org/10.1038/s415...
π§΅
21.05.2025 15:43 β π 128 π 42 π¬ 7 π 10
title of assistant professor's talk: amino acid metabolism of effector T cells in LCMV infection
title of senior full professor's talk: Why do cells eat?
20.05.2025 16:19 β π 82 π 9 π¬ 7 π 1
Targeting inflammation with chimeric antigen receptor macrophages using a signal switch - Nature Biomedical Engineering
Anti-TNF CAR macrophages show anti-inflammatory efficacy in both acute and chronic inflammatory disease mouse models.
Cells as living drugs is a big part of future medical approaches.
There's been so much about engineering T cells (CAR-T) for treatment of cancer and autoimmune diseases. But engineering macrophages (CAR-M) is next up for blocking inflammation.
www.nature.com/articles/s41...
10.05.2025 19:39 β π 188 π 40 π¬ 2 π 1
A wonderful interview with our @yalecvrc.bsky.social colleague Martin Schwartz! Where science is like art: learning to define your taste in questions
21.04.2025 23:42 β π 22 π 2 π¬ 0 π 0
In today's episode of the Night Science Podcast we talk with Martin Schwartz from Yale about the importance of stupidity in science: while learning science makes you feel smart, true scientific discovery often involves feeling stupid, because it means venturing into the unknown.
21.04.2025 11:31 β π 200 π 56 π¬ 3 π 11
Teaching machines the language of biology: Scaling large language models for next-generation single-cell analysis
What if LLMs could βreadβ & βwriteβ biology? π€
Introducing C2SβScaleβa Yale and Google collab: we scaled LLMs (up to 27B!) to analyze & generate singleβcell data 𧬠β‘οΈ π
π Blog: research.google/blog/teachin...
π Preprint: biorxiv.org/content/10.1...
18.04.2025 14:13 β π 18 π 10 π¬ 2 π 0
As promised, a 'skeet' -orial on our paper published last week !
14.04.2025 13:05 β π 29 π 10 π¬ 1 π 0
Ranking of Variant Effect Predictor (VEP) in-silico tools from a recently published review, based on Relative performance with rate on MAVE data)
1. CPT-1 (Broad Institute)
2. AlphaMissense (Google DeepMind and cols.)
3. ESCOTT (Sorbonne/INSERM France)
16.04.2025 09:41 β π 23 π 4 π¬ 0 π 0
π¨ Job alert! π¨
The Chung Lab @ Yale seeks a motivated, creative postdoc to examine tissue remodeling in health and disease. We study ovarian aging and cardiovascular disease in human samples and animal models. Passionate about single-cell, spatial genomics, machine learning & therapeutics? Join us!
02.04.2025 13:27 β π 9 π 7 π¬ 1 π 0
Myocarditis is a focus of many concerns. It is not a side effect of a particular vaccine but of the immune response following vaccination or infection! The latter, infection, is a much more serious event.
A systemic review of over 400 million people; 1947 to 2021:
17.11.2024 12:36 β π 53 π 16 π¬ 1 π 1
Growth of the maternal intestine during reproduction @cellcellpress.bsky.social @irenemiguel-aliaga.bsky.social
www.cell.com/cell/fulltex...
19.03.2025 17:47 β π 11 π 5 π¬ 0 π 0
we recently found some really neat RNA-guided DNA-cutting systems in phages. Despite remarkable similarities to CRISPR systems, including encoding guide RNAs in arrays, they appear entirely evolutionarily distinct (but definitely related to snoRNAs π€)
We decided to call them TIGR-Tas systems π―
01.03.2025 00:18 β π 210 π 79 π¬ 2 π 4
PhD student in Computational Biology & Biomedical Informatics at Yale University
Yale Institute for Foundations of Data Science.
Exploring how the environment, brain & body interact to shape human health π¬ | Faculty at Stanford & Core Investigator at @arcinstitute.org
http://www.thaisslab.com
Assistant Prof. at Stanford & Innovation Investigator at @arcinstitute.orgβ¬ | Studying metabolites and their impact on physiology and disease π¦ π§ͺ
www.arcinstitute.org/labs/levylab
Immunology with a touch of regenerative medicine (or is it the other way around?). Thymus enthusiast at Fred Hutch (previously seen around Monash Uni & Sloan Kettering Institute) π¦πΊ in πΊπΈ
Deciphering the human immune system to improve human health for all.
humanimmunomeproject.org
PhD Student studying human brain tissue using and expanding single-cell genomic methologies. Berlin, Germany
A multidisciplinary community of researchers with the mission to better understand the roots of disease and narrow the gap between new biological insights and impact for patients. Broadinstitute.org
ML + Cells + Proteins. PI @ Aithyra
AITHYRA is a new dynamic research institute for biomedical AI in Vienna. AITHYRA seeks to build Europeβs premier institute for AI-driven biological and medical research, uniting computer scientists, engineers, and biologists in a collaborative environment.
π¬ Assistant Prof, Pathology βͺ@Duke | Director, Clin Micro Lab
π§« Former Clin Micro Fellow βͺ@Memorial Sloan Kettering
π©π»βπ¬ Former Postdoc @broadinstitute.org
π PhD @The Rockefeller University
Focus: Diagnostics, AMR, Structural Biology
This is the official account for the Society for Developmental Biology. Skeets on all the latest Dev Bio news, meetings and science! www.sdbonline.org
Chemically dissecting hostβmicrobe interactions at Yale University
Genetics faculty @ Yale: genetics, genomics, chromatin, reproduction, and evolution. Or really, just trying to see where the next result takes us.
Macrophage and stem cell biologist. Interested in rebuilding tissues. Assistant Professor at @princetonmolbio.bsky.social. Opinions are my own. He/him.
https://mesa-lab.org/
your daily dose of bunnies βΈ(ο½‘Λ α΅ Λ )βΈβ‘
The SMB is dedicated to the advancement of research at the interface between the mathematical and biological sciences. smb.org
Rubisco, protein engineering and photosynthesis. Starting a lab in the Cambridge biochemistry department this fall.
pryweslab.org
Assistant Professor of Bioengineering at Stanford