Tom Doherty

Assessing the clinical meaningfulness of slowing CDR‐SB progression with disease‐modifying therapies for Alzheimer's disease INTRODUCTION For many patients and caregivers, a major goal of disease-modifying treatments (DMTs) for Alzheimer's disease (AD) dementia is to extend independence in instrumental and basic activitie.....

Assessing the clinical meaningfulness of slowing CDR‐SB progression with disease‐modifying therapies for Alzheimer's disease in A&D:TRCI by Hartz et al.

Changes in the CDR-SB were connected to time of retaining functions like paying bills and driving. #ENDALZ

doi.org/10.1002/trc2...

Trump's new age of acquiesence The first week has been dark stuff. In pardoning the Jan6th insurrectionists, Trump has achieved the ultimate victory: over history itself.

In pardoning all of the J6th insurrectionists, with barely a whimper of opposition, Trump has signalled a new age of acquiescence in American politics.

He's trying to control not just the present but the past. In effect, he was pardoning himself.

New from me. open.substack.com/pub/goodalla...

Clinical use of biomarkers in the era of Alzheimer's disease treatments With the advent of treatments that specifically target Alzheimer's disease brain pathology, biomarker tests will become an increasingly important part of the routine clinical evaluation of cognitive ....

This article discusses clinical use of biomarker tests for Alzheimer's disease pathology, including indications for testing, review of biomarker modalities (PET, CSF, blood), selection of modality based on individual factors, and interpretation and return of results. #ENDALZ
doi.org/10.1002/alz....

‘My God there is light’: CNN witnesses moment Syrian prisoner is freed from Assad’s forced detention | CNN While searching a secretive prison in the belly of the Assad regime’s legacy of torture for American journalist Austin Tice, CNN’s Clarissa Ward made a startling discovery when a rebel fighter uncover...

I hope everyone will watch this video from Syria. Extraordinary, terrifying and hopeful moments.

It's a reminder of why we fight.

www.cnn.com/2024/12/11/w...

A ‘Second Tree of Life’ Could Wreak Havoc, Scientists Warn (Gift Article) Research on so-called mirror cells, which defy fundamental properties of living organisms, should be prohibited as too dangerous, biologists said.

Over 30 prominent scientists call for a ban on the creation of a "mirror cell"--a microbe made of molecules that are mirror images of their natural forms. It could cause a mind-boggling global disaster. Here's my story [gift link] 🧪https://nyti.ms/3OUCXp6

Plasma pTau217 predicts continuous brain amyloid levels in preclinical and early Alzheimer's disease BACKGROUND This study investigated the potential of phosphorylated plasma Tau217 ratio (pTau217R) and plasma amyloid beta (Aβ) 42/Aβ40 in predicting brain amyloid levels measured by positron emissio...

This work further demonstrates the utility of ptau217R for disease stage assessment, patient screening and monitoring, in clinical trials and clinical practice.

It also builds on our prior work on predicting amyloid values across the AD continuum alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

This research demonstrates the ability to also reliably predict tau levels simultaneously across Braak stages and multiple brain regions via a single, unified model. Notably, a pTau217R-based algorithm could lower the need for tau PET scans by up to 65% while maintaining 95% sensitivity.

Plasma pTau217 ratio predicts continuous regional brain tau accumulation in amyloid‐positive early Alzheimer's disease BACKGROUND This study examines whether phosphorylated plasma Tau217 ratio (pTau217R) can predict tau accumulation in different brain regions, as measured by positron emission tomography (PET) standa...

Happy to share our latest publication on predicting regional Tau PET loads using blood based biomarkers. We used the Tau PET data from Clarity AD and the ADNI cohort to predict continuous regional tau loads (AUCs 0.71-0.95).

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...