Struan Grant

Re-posting given recent adds
go.bsky.app/9asWtuD

Post Doctoral Research Fellow – Circadian Biology and Genomics in Philadelphia, Pennsylvania, United States of America | Fellows, Students & Interns at Children’s Hospital of Philadelphia Apply for Post Doctoral Research Fellow – Circadian Biology and Genomics job with Children’s Hospital of Philadelphia in Philadelphia, Pennsylvania, United States of America. Fellows, Students & Inter...

My lab is seeking to co-hire a postdoctoral fellow with the @shaonsengupta.bsky.social team. See details below!

careers.chop.edu/us/en/job/10...

Obesity Prediction Could Be Guided by Genetic Risk Scores

Delighted to contribute, along locally with @alessandrachesi.bsky.social and @jonathanbradfield.bsky.social‬: "Polygenic prediction of body mass index and obesity through the life course and across ancestries".

www.nytimes.com/2025/07/21/h...

www.nature.com/articles/s41...

Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous ...

Happy to announce our paper comparing embryonic gene expression between C. elegans and C. briggsae, work led by Christopher Large with Rupa Khanal and in collaboration with Junhyong Kim and Bob Waterston. www.science.org/doi/10.1126/...

Excited to to see our collaboration with @gburslem.bsky.social published today! This is part of our ongoing long term goal of achieving scalable non-disruptive and direct imaging and perturbation of the endogenous proteome

Inside AJHG: A Chat with Max Dudek Editors of The American Journal of Human Genetics sat down with Max Dudek, BS, to discuss his recently published paper, “Characterization of non-coding variants associated with transcription-factor bi...

Great to see @maxdudek.bsky.social in the @upenngcb.bsky.social program interviewed by @ajhgnews.bsky.social

www.ashg.org/ajhg/inside-...

Eli Lilly to acquire gene-editing therapy developer Verve Therapeutics for up to $1.3 billion, companies say Eli Lilly will acquire Verve Therapeutics for up to $1.3 billion, the companies said on Tuesday.

Eli Lilly to acquire gene-editing therapy developer Verve Therapeutics for up to $1.3 billion, companies say reut.rs/4jWP3LH

Atul Butte died yesterday.
The world lost a giant.
A big bear of a man.
With a huge smile.
With love for everyone.
With energy that could power a room.
I loved everything about Atul.
I loved how he was always happy.
I loved how excited he was about science and helping people.

Wow!! Big thanks for the very lovely preview!! 🫶🫶🫶

TOO MANY analyses -> very DIFFERENT feedback on (several of) our submissions - some thought it was too lengthy, others considered the design creative, rigorous.

Perhaps no need to do standard analyses if the data/question itself is not standard...

Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms Leveraging Finnish nationwide multi-generational registers and the biobanks of FinnGen, Wang, Liu, et al. investigated the effect of parental autoimmune diseases on offspring T1D. Their creative and r...

@agacita.bsky.social & I preview: "Parental autoimmunity genetics & offspring T1D risk" www.cell.com/cell-genomic... for new #CellGenomics study: "Effects of parental autoimmune diseases on T1D in offspring can be partially explained by HLA & non-HLA polymorphisms" www.cell.com/cell-genomic...

Great talk @j-a-mitchell.bsky.social!

SLEEP 2025 | APSS Annual Meeting | AASM | SRS SLEEP is the premier conference dedicated to clinical sleep medicine, sleep and circadian research, and sleep health.

Check out my @chopresearch.bsky.social colleague (& fellow Scot!), @j-a-mitchell.bsky.social's #SLEEP2025 talk this afternoon: "Actigraphy-Estimated Rest-Activity Rhythm Characteristics of Adolescents by Socio-Demographic Factors" - covering work by Misol Kwon. 2.30pm, Room 619
www.sleepmeeting.org

Looking forward to presenting at the Trainee Symposium this morning at #SLEEP2025 here in beautiful Seattle - together with Hanna Ollila and Brittany Bush. Come on by! "Genetic Insights into Sleep Disorders" session - 9.10am Room 212.

www.sleepmeeting.org/schedule/hig...

Check out @maxdudek.bsky.social paper on fpQTLs!

www.cell.com/ajhg/fulltex...

Delighted to contribute, along with locally @adwellspenn.bsky.social & @alessandrachesi.bsky.social‬. "Mapping chromatin interactions at melanoma susceptibility loci uncovers distant cis-regulatory gene targets" @chopresearch.bsky.social @penngenetics.bsky.social
authors.elsevier.com/c/1l8KggeXDz0y

Go Spurs! Great to see them win a trophy after all the years of drought. I’m sure the press room will be busier than when I was there as a tourist 🤣

No better way to celebrate 10 years(!!) since joining the Grant lab than to celebrate at my PhD graduation! @struangrant.bsky.social I am so grateful for all the years of mentorship, and I’m so excited to continue collaborating with you and the rest of our colleagues at Penn/CHOP for years to come!

Dr. Rebecca Ahrens-Nicklas

In a landmark scientific feat published in NEJM, a CHOP & Penn Medicine team treated the first patient with personalized #genetherapy, designed uniquely for newborn KJ, who was diagnosed with a rare #ureacycledisorder at birth. Learn more: http://ms.spr.ly/63327Sw92F

Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM Base editors can correct disease-causing genetic variants. After a neonate had received a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with an estimated 50% mortality ...

www.nejm.org/doi/full/10....

Baby Is Healed With World’s First Personalized Gene-Editing Treatment

Congratulations to @ahrensnicklas.bsky.social, @kiranmusunuru.bsky.social and their collaborators!

www.nytimes.com/2025/05/15/h...

Philly's Amber Zimmerman wins the #BroadStreetRun for a second year in a row on the women's side, finishing in 54:01.81.

Allelic effects on KLHL17 expression underlie a pancreatic cancer genome-wide association signal at chr1p36.33 - Nature Communications Allele-preferential transcription factor binding can influence pancreatic ductal adenocarcinoma risk loci function. Here, the authors show allele-specific JunB and JunD binding at chr1p36.33 and propo...

I'm excited to share that our functional characterization of the 1p36.33 pancreatic cancer risk locus, is now live in Nature Communications. @amundadottir.bsky.social

www.nature.com/articles/s41...

Prevalence and predictors of low bone mineral density in pediatric inflammatory bowel disease Objectives Bone health is at risk in children with inflammatory bowel disease (IBD). This study examined the prevalence and predictors of low bone mineral density (BMD) in a cohort of children and y...

Delighted to contribute: "Prevalence and predictors of low bone mineral density in pediatric inflammatory bowel disease". @chopresearch.bsky.social

onlinelibrary.wiley.com/doi/full/10....

GWAS-Informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density Over 1,100 independent signals have been identified with genome-wide association studies (GWAS) for bone mineral density (BMD), a key risk factor for mortality-increasing fragility fractures; however,...

Thesis work: www.biorxiv.org/content/10.1...

Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program One of the justifiable criticisms of human genetic studies is the underrepresentation of participants from diverse populations. Lack of inclusion must be addressed at-scale to identify causal disease ...

Thesis work:
www.science.org/doi/10.1126/...

Congratulations to Dr. Mitch Conery for winning this year's @upenngcb.bsky.social Saul Winegrad Award for Outstanding Dissertation! @bvoight28.bsky.social and I are the proud co-mentors. @penngenetics.bsky.social @chopresearch.bsky.social

Great show

Accelerating Medicines Partnership in Type 2 Diabetes and Common Metabolic Diseases: Collaborating to Maximize the Value of Genetic and Genomic Data In the last two decades, significant progress has been made toward understanding the genetic basis of type 2 diabetes. An important supporter of this resea

Delighted to have contributed to this editorial
diabetesjournals.org/diabetes/art...

The gSOS Polygenic Score is Associated with Bone Density and Fracture Risk in Childhood The polygenic risk score genetic quantitative ultrasound speed of sound (gSOS) was developed using machine learning algorithms in adults of European ancestry and associates with reduced odds of fractu...

PREPRINT: Led by @j-a-mitchell.bsky.social & Babette Zemel, we show higher gSOS polygenic score associated with higher pediatric aBMD 🦴 & lower fracture risk @chopresearch.bsky.social . gSOS previously developed with ML on adults by @brent-richards.bsky.social team

www.medrxiv.org/content/10.1...

Characterization of non-coding variants associated with transcription-factor binding through ATAC-seq-defined footprint QTLs in liver Dudek et al. use chromatin accessibility data in liver from 170 human donors to measure transcription factor binding at genetic variants. They observed 809 variants associated with binding. Given bind...

Our new paper is out today in AJHG! We applied a "footprinting" algorithm to ATAC-seq data from 170 livers to find non-coding variants associated with TF binding. We show that these "footprint QTLs" (#fpQTLs) can fine-map GWAS loci at base-pair resolution.
www.cell.com/ajhg/fulltex...