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@martin-belmontef.bsky.social

43 Followers  |  44 Following  |  7 Posts  |  Joined: 03.12.2024  |  1.7685

Latest posts by martin-belmontef.bsky.social on Bluesky

Congrats!!

17.09.2025 15:27 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Mitochondria-Lysosome Crosstalk Shapes Metabolic Transition in Neonatal Enterocytes The neonatal gastrointestinal tract mediates nutrient absorption and the establishment of immune tolerance to commensal microbiota. In early life, lysosome-rich enterocytes (LREs) in the ileum are nec...

Mitochondria-Lysosome Crosstalk Shapes Metabolic Transition in Neonatal Enterocytes
Gonzalo Herranz, et al. 2025 bioRxiv 2025.09.09.674148; doi: doi.org/10.1101/2025...

16.09.2025 09:43 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Childhood malnutrition remains a major global health challenge. Our work reveals how organelle crosstalk in neonatal gut cells safeguards nutrition and development โ€” and how its failure resembles Kwashiorkor.

16.09.2025 09:43 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
Martin-Belmonte and Martinez-Martin at CBMSO

Martin-Belmonte and Martinez-Martin at CBMSO

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๐Ÿšจ New paper out!
Neonatal enterocytes rely on autophagy & mitophagy to sustain nutrient absorption. Our study demonstrates that the mitochondriaโ€“lysosome axis controls the weaning transition and may contribute to childhood malnutrition.
๐Ÿ‘‰https://www.biorxiv.org/content/10.1101/2025.09.09.674148v3

16.09.2025 09:43 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Thank you Sofia
Best
F

30.04.2025 08:17 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
 Graphical model showing the effect of CASM autophagy in lumen resolution of epithelial tubes.

Graphical model showing the effect of CASM autophagy in lumen resolution of epithelial tubes.

๐Ÿงช Canonical autophagy isnโ€™t enough! In our new study, only CASM can coordinate the membrane remodeling needed to build a single lumen in tubes. Read how CASM drives endocytic recycling to drive morphogenesis www.biorxiv.org/content/10.1...
#ScienceTwitter #Autophagy #Morphogenesis #CellPolarity

29.04.2025 07:42 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
ATG16L1 KO H1-human Neural Tube organoids fail to resolve ML at day
5 of development. Cells were stained for actin (red) and nuclei (blue). Dotted lines indicate the lumens.

ATG16L1 KO H1-human Neural Tube organoids fail to resolve ML at day 5 of development. Cells were stained for actin (red) and nuclei (blue). Dotted lines indicate the lumens.

๐Ÿšจ New paper out! We reveal that noncanonical autophagy (CASM) is a critical driver of epithelial lumen formation. CASM regulates endocytic recycling and membrane remodelingโ€”without it, cells canโ€™t resolve into a single lumen.
www.biorxiv.org/content/10.1...

29.04.2025 07:37 โ€” ๐Ÿ‘ 4    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1

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