Centre for Muscle Research (CMR)

Check out the new post-doc opportunity in the Lab of Prof Matt Watt, in collaboration with an industry partner, on muscle signalling and metabolism related to metabolic disease and future obesity treatments
unimelb.wd105.myworkdayjobs.com/UoM_External...

It's time to register for the 2025 Victorian Muscle Network Symposium! 🚨
Please register now: victorianmusclenetwork.wordpress.com
🗓️Make sure to register by the 14th of September
👀 Keynote speakers to be confirmed soon

Intramuscular CMT‐167 Tumours Produce a Mild Cachexia Phenotype in C57BL/6J Mice Background Cancer cachexia is a debilitating syndrome characterized by irreversible losses in skeletal muscle mass, with or without losses in adipose tissue. Cancer cachexia is an underrecognized sy...

Congrats to Bryan Remaily, Chris Coss, Mitch Phelps, and Team, for their new JCSM Commications paper "Intramuscular CMT-167 Tumours Produce a Mild Cachexia Phenotype in C57BL/6J Mice", that included the CMR's Prof Paul Gregorevic

onlinelibrary.wiley.com/doi/10.1002/...

The CMR recognises #WorldSarcopeniaDay.
Interrogating ways to preserve muscle function as we age is a major theme of study in the CMR & our researchers continue to make contributions to the field.
#Myotwitter #sarcopenia #aging #longevity #health #exercise

Skeletal muscle proteomics: considerations and opportunities - npj Metabolic Health and Disease npj Metabolic Health and Disease - Skeletal muscle proteomics: considerations and opportunities

Checkout the new review paper from the CMR's Julian Wong, Yaan-Kit Ng, Ronnie Blazev & @benparkerlab.bsky.social & the NNF CBMR's Jeppe Kjærgaard & @adeshmukh.bsky.social on Skeletal Muscle Proteomics: Considerations and Opportunities.
www.nature.com/articles/s44...

Congratulations to Amy Bongetti, Dr Marissa Caldow, Dr Yasmine Ali Abdelhamid and Prof Gordon Lynch for their new review paper, "Evaluating skeletal muscle wasting and weakness in models of critical illness".
#muscle #ICU
portlandpress.com/clinsci/arti...

Impaired muscle metabolism in the ICU: interrogating the... : Current Opinion in Critical Care lled trials in critically ill adults have reported signals of harm from higher protein administration compared to lower protein doses or standard of care, with significant results pertaining to reduce...

Congratulations to Lee-Anne Chapple,the CMR's Gordon Lynch and Olav Rooyackers for their new review on "Impaired muscle metabolism in the ICU: interrogating the underlying pathophysiology".

journals.lww.com/co-criticalc...

A place for physiologist of Australia to connect, share, and promote each other’s work in cutting-edge research and education. Follow us to stay updated on the latest in physiology, events, and opportunities!
🔗 Tag your colleagues, share your research, and let’s grow this community together!

The Australian Physiological Society (AuPS) is now on BlueSky:
‪@aups-physiology.bsky.social‬

Haptoglobin and Glutamine Synthetase May Biomark Cachexia Induced by Antiacute Myeloid Leukaemia Chemotherapy Background Anticancer chemotherapy is an underappreciated contributor to cancer cachexia, an often-irreversible body-wasting condition that causes 20%–30% of cancer-related deaths. An obstacle to pr...

Congrats to Dr Dean Campelj, Prof Emma Rybalka & Team for their new JCSM paper "Haptoglobin & Glutamine Synthetase May Biomark Cachexia Induced by Antiacute Myeloid Leukaemia Chemotherapy" that also involved the CMR's @craigagoodman1.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...

Victorian Muscle Network (VMN)
✨SAVE THE DATE!✨
Please join us for the 8th Victorian Muscle Network Symposium to be held on Friday the 14th of November at Monash Caulfield Campus.
Keep an eye out for updates on keynote speakers and registrations👀
Looking forward to seeing you all there in 2025 🥳

Well done Chris Karagiannis for delivering an outstanding PhD oration! The CMR and his supervisors, Prof Paul Gregorevic, @craigagoodman1.bsky.social & Dr Rachel Thomson, are proud. Now for the thesis.
#cancer #cachexia #muscle

Congrats Amy Bongetti on your PhD thesis submission!
Flanked by proud supervisors, Dr Marissa Caldow, Dr Yasmine Ali Abdelhamid , Prof Gordon Lynch
#muscle #ICU #physiology

Mechanically sensitive MAPK signalling mediates resistance exercise-induced muscle growth - Nature Metabolism Understanding the molecular regulators of skeletal muscle mass is essential for the future development of therapies that promote muscle growth and/or inhibit muscle wasting. A new study shows that mus...

Check out the News and Views in @natmetabolism.nature.com by Sue Bodine & the CMR's @craigagoodman1.bsky.social on a new study from Troy Hornberger's lab on mechanically-sensitive MKK3b/6, p38, MK2, mTORC1 signaling mediating resistance exercise-induced muscle growth www.nature.com/articles/s42...

Site-specific quantification of the in vivo UFMylome reveals myosin modification in ALS UFMylation is the post-translational modification of Ubiquitin Fold Modifier1 (UFM1) applied to substrate proteins. Blazev et al. develop an antibody-based enrichment approach followed by LC-MS/MS to ...

Congrats to Ronnie Blazev, @benparkerlab.bsky.social and Team for their new paper, "Site-specific quantification of the in vivo UFMylome reveals myosin modification in ALS", that also involved CMR members Yann-Kit Ng, @craigagoodman1.bsky.social & Paul Gregorevic
#ALS
www.cell.com/cell-reports...

Congrats to Maddy Meli & Brett Comer for their paper, "Ngn2-Induced Differentiation of the NG108-15 Cell Line Enhances Motor Neuronal Differentiation and Neuromuscular Junction Formation", also involving the CMR's @kristyswid.bsky.social Marissa Caldow & Gordon Lynch
www.mdpi.com/2218-273X/15...

A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosis These findings support CET polytherapy as an advantageous alternative compared to CuATSM monotherapy and highlight the potential of utilising small molecules targeting SOD1 as a polytherapy avenue for...

Congrats to Jeremy Lum, Justin Yerbury and Team for their new paper, "A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosis', that also involved the CMR's A/P Peter Crouch
#ALS
www.thelancet.com/journals/ebi...

Parkinson-like wild-type superoxide dismutase 1 pathology induces nigral dopamine neuron degeneration in a novel murine model - Acta Neuropathologica Atypical wild-type superoxide dismutase 1 (SOD1) protein misfolding and deposition occurs specifically within the degenerating substantia nigra pars compacta (SNc) in Parkinson disease. Mechanisms dri...

Congrats to Amr Abdeen, the CMR's A/P Peter Crouch, Kay Double, & Team, for their new paper, "Parkinson-like wild-type superoxide dismutase 1 pathology induces nigral dopamine neuron degeneration in a novel murine model"
#parkinson's
link.springer.com/article/10.1...

Congrats to Alastair Saunders on a great PhD oration on Metastatic Cancer and Muscle: Exploring the role of TGF-beta signaling in metastatic colonisation. The CMR and supervisors, Profs Paul Gregorevic & Robin Anderson, are very proud. Good luck with the thesis! #Myoblue #cancer #metastasis #muscle

The CMR's Craig Goodman @craigagoodman1.bsky.social
presenting on the ubiquitinomics of muscle hypertrophy in today's morning session on Muscle Growth and Regeneration at the Advances in Skeletal Muscle Biology (ASMB) Conference at UFMyology

A great opening session of speakers on the topic of cancer cachexia at the Advances in Skeletal Muscle Biology (ASMB) conference at UFMyology, which included the CMR's Prof Paul Gregorevic

To celebrate International Women’s Day, we would like to recognise the dedication and hard work of the amazing women (staff and students) of the CMR.
#internationalwomensday #IWD2025 #Myoblue

Congrats to Jess Day, Ian Wicks & Team for their new @jci-insight.bsky.social paper on "Periarticular myositis and muscle fibrosis are cytokine dependent complications of inflammatory arthritis", that also involved the CMR's @kristyswid.bsky.social & Gordon Lynch
insight.jci.org/articles/vie...

Today is Rare Disease Day.
There are >6000 rare diseases that affect >300 million people, including Duchenne (DMD), Myotonic (DM) & Facioscapulohumeral (FSHD) muscular dystrophies & Motor Neuron Disease (MND), that are studied at the CMR.
#RareDiseaseDay #Duchenne #FSHD #muscle #myoblue

Congratulations to Amy Bongetti on a wonderful PhD oration with the title of 'Investigating Muscle Wasting and Weakness in Critical Illness: From Bench to Bedside'

The CMR is very proud. Now for the thesis!

#Myoblue #muscle #illness #wasting

To celebrate International Day of Women and Girls in Science, we would like recognise the dedication and hard work of the amazing women (staff and students) of the CMR. #WomenInScience and #GirlsInSTEM #IDWGIS

We would like to thank A/P Doug Millay for visiting the CMR, showcasing his great science, and interacting with our students and staff.

Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...

Congratulations to Adriana Miranda-Cervantes, Maximilian Kleinert and Team for their new paper, "Pantothenate kinase 4 controls skeletal muscle substrate metabolism", that also involved the CMR's Prof Paul Gregorevic.

www.nature.com/articles/s41...

Altering phosphorylation of dystrophin S3059 to attenuate cancer cachexia Cancer cachexia affects up to 80 % of patients with advanced cancer and accounts for >20 % of all cancer-related deaths. Sarcolemmal localization of d…

Congratulations to the CMR's @kristyswid.bsky.social, Prof Gordon Lynch, and extended Team, for their new paper on "Altering phosphorylation of dystrophin S3059 to attenuate cancer cachexia".
@wehi-research.bsky.social
@latrobeuni.bsky.social
www.sciencedirect.com/science/arti...

The Potential of Targeting APE1/Ref-1 as a Therapeutic Intervention for Duchenne Muscular Dystrophy | Antioxidants & Redox Signaling Significance: Inflammation and oxidative stress play crucial roles in the development and progression of skeletal muscle diseases. This review aims to examine the existing evidence regarding the invol...

Congrats to PhD student, Hannah Lalunio, Dr Nicole Stupka, Prof Alan Hayes, and the CMR's @craigagoodman1.bsky.social for their new review on "The Potential of Targeting APE1/Ref-1 as a Therapeutic Intervention for Duchenne Muscular Dystrophy"
www.liebertpub.com/doi/10.1089/...