Centre for Muscle Research (CMR)

Translational progress in the development of pharmacotherapies for Duchenne muscular dystrophy Despite the discovery, nearly 40 years ago, that mutations in the dystrophin gene were responsible for Duchenne muscular dystrophy (DMD), a cure for this devastating disease remains elusive. Consid...

Congratulations to the CMR's @kristyswid.bsky.social and Prof Gordon Lynch for their new review paper on "Translational progress in the development of pharmacotherapies for Duchenne muscular dystrophy"
www.tandfonline.com/doi/full/10....
@mda.org

Congratulations to CMR PhD student, John Nguyen, on receiving a @aegeanconf.bsky.social Trainee Award at the 6th International Conference on Stem Cells, in Sissi, Crete, Greece.
#muscle #Myotwitter #stemcells #regeneration #metabolism #physiology

Congratulations to John Nguyen on a successful PhD oration: ‘Metabolic control of skeletal muscle regeneration’. Now for the thesis!
Supervisors: Prof Gordon Lynch, @kristyswid.bsky.social, Assoc Prof Kristin Brown, @craigagoodman1.bsky.social
#muscle #stemcells #regeneration #injury #metabolism

The CMR gathers wearing green to celebrate International Myotonic Dystrophy Awareness Day to promote research & funding to improve the lives of those affected by DM, a neuromuscular disease causing progressive muscle weakness
@mda.org @myotonicstrong.bsky.social #muscle

The CMR is on a mission to understand and treat DMD and other neuromuscular disorders. We remain deeply committed to, and passionately support, #WDAD2025
#muscle #Duchenne #dystrophy #muscular

Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis Long-term exercise training elicits tremendous health benefits; however, the molecular understanding is incomplete and identifying therapeutic targets…

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Congrats to Steffen Raun, Lykke Sylow and Team for their new Redox Biology paper, "Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis", that included the CMR's Prof Paul Gregorevic
www.sciencedirect.com/science/arti...

Generation and evaluation of a novel PI3K-targeting gene therapy in the failing mouse heart and healthy sheep heart Heart failure (HF) remains a clinical challenge with cardiac dysfunction typically progressing even with treatment, and heart transplants only availab…

Congrats to Sebastian BassStringer, Prof Juli McMullen & Team for their new paper "Generation and evaluation of a novel PI3K-targeting gene therapy in the failing mouse heart and healthy sheep heart", that included the CMR's Prof Paul Gregorevic
www.sciencedirect.com/science/arti...

Congratulations to Kevin (Yansong) Lu & Prof Pete Currie of the Australian Regenerative Medicine Institute (ARMI), and the CMR's Dr Avnika Ruparelia, for their new review paper, "Zebrafish: Lessons and Insights into Skeletal Muscle Research"

cshperspectives.cshlp.org/content/earl...

Check out the new post-doc opportunity in the Lab of Prof Matt Watt, in collaboration with an industry partner, on muscle signalling and metabolism related to metabolic disease and future obesity treatments
unimelb.wd105.myworkdayjobs.com/UoM_External...

It's time to register for the 2025 Victorian Muscle Network Symposium! 🚨
Please register now: victorianmusclenetwork.wordpress.com
🗓️Make sure to register by the 14th of September
👀 Keynote speakers to be confirmed soon

Intramuscular CMT‐167 Tumours Produce a Mild Cachexia Phenotype in C57BL/6J Mice Background Cancer cachexia is a debilitating syndrome characterized by irreversible losses in skeletal muscle mass, with or without losses in adipose tissue. Cancer cachexia is an underrecognized sy...

Congrats to Bryan Remaily, Chris Coss, Mitch Phelps, and Team, for their new JCSM Commications paper "Intramuscular CMT-167 Tumours Produce a Mild Cachexia Phenotype in C57BL/6J Mice", that included the CMR's Prof Paul Gregorevic

onlinelibrary.wiley.com/doi/10.1002/...

The CMR recognises #WorldSarcopeniaDay.
Interrogating ways to preserve muscle function as we age is a major theme of study in the CMR & our researchers continue to make contributions to the field.
#Myotwitter #sarcopenia #aging #longevity #health #exercise

Skeletal muscle proteomics: considerations and opportunities - npj Metabolic Health and Disease npj Metabolic Health and Disease - Skeletal muscle proteomics: considerations and opportunities

Checkout the new review paper from the CMR's Julian Wong, Yaan-Kit Ng, Ronnie Blazev & @benparkerlab.bsky.social & the NNF CBMR's Jeppe Kjærgaard & @adeshmukh.bsky.social on Skeletal Muscle Proteomics: Considerations and Opportunities.
www.nature.com/articles/s44...

Congratulations to Amy Bongetti, Dr Marissa Caldow, Dr Yasmine Ali Abdelhamid and Prof Gordon Lynch for their new review paper, "Evaluating skeletal muscle wasting and weakness in models of critical illness".
#muscle #ICU
portlandpress.com/clinsci/arti...

Impaired muscle metabolism in the ICU: interrogating the... : Current Opinion in Critical Care lled trials in critically ill adults have reported signals of harm from higher protein administration compared to lower protein doses or standard of care, with significant results pertaining to reduce...

Congratulations to Lee-Anne Chapple,the CMR's Gordon Lynch and Olav Rooyackers for their new review on "Impaired muscle metabolism in the ICU: interrogating the underlying pathophysiology".

journals.lww.com/co-criticalc...

A place for physiologist of Australia to connect, share, and promote each other’s work in cutting-edge research and education. Follow us to stay updated on the latest in physiology, events, and opportunities!
🔗 Tag your colleagues, share your research, and let’s grow this community together!

The Australian Physiological Society (AuPS) is now on BlueSky:
‪@aups-physiology.bsky.social‬

Haptoglobin and Glutamine Synthetase May Biomark Cachexia Induced by Antiacute Myeloid Leukaemia Chemotherapy Background Anticancer chemotherapy is an underappreciated contributor to cancer cachexia, an often-irreversible body-wasting condition that causes 20%–30% of cancer-related deaths. An obstacle to pr...

Congrats to Dr Dean Campelj, Prof Emma Rybalka & Team for their new JCSM paper "Haptoglobin & Glutamine Synthetase May Biomark Cachexia Induced by Antiacute Myeloid Leukaemia Chemotherapy" that also involved the CMR's @craigagoodman1.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...

Victorian Muscle Network (VMN)
✨SAVE THE DATE!✨
Please join us for the 8th Victorian Muscle Network Symposium to be held on Friday the 14th of November at Monash Caulfield Campus.
Keep an eye out for updates on keynote speakers and registrations👀
Looking forward to seeing you all there in 2025 🥳

Well done Chris Karagiannis for delivering an outstanding PhD oration! The CMR and his supervisors, Prof Paul Gregorevic, @craigagoodman1.bsky.social & Dr Rachel Thomson, are proud. Now for the thesis.
#cancer #cachexia #muscle

Congrats Amy Bongetti on your PhD thesis submission!
Flanked by proud supervisors, Dr Marissa Caldow, Dr Yasmine Ali Abdelhamid , Prof Gordon Lynch
#muscle #ICU #physiology

Mechanically sensitive MAPK signalling mediates resistance exercise-induced muscle growth - Nature Metabolism Understanding the molecular regulators of skeletal muscle mass is essential for the future development of therapies that promote muscle growth and/or inhibit muscle wasting. A new study shows that mus...

Check out the News and Views in @natmetabolism.nature.com by Sue Bodine & the CMR's @craigagoodman1.bsky.social on a new study from Troy Hornberger's lab on mechanically-sensitive MKK3b/6, p38, MK2, mTORC1 signaling mediating resistance exercise-induced muscle growth www.nature.com/articles/s42...

Site-specific quantification of the in vivo UFMylome reveals myosin modification in ALS UFMylation is the post-translational modification of Ubiquitin Fold Modifier1 (UFM1) applied to substrate proteins. Blazev et al. develop an antibody-based enrichment approach followed by LC-MS/MS to ...

Congrats to Ronnie Blazev, @benparkerlab.bsky.social and Team for their new paper, "Site-specific quantification of the in vivo UFMylome reveals myosin modification in ALS", that also involved CMR members Yann-Kit Ng, @craigagoodman1.bsky.social & Paul Gregorevic
#ALS
www.cell.com/cell-reports...

Congrats to Maddy Meli & Brett Comer for their paper, "Ngn2-Induced Differentiation of the NG108-15 Cell Line Enhances Motor Neuronal Differentiation and Neuromuscular Junction Formation", also involving the CMR's @kristyswid.bsky.social Marissa Caldow & Gordon Lynch
www.mdpi.com/2218-273X/15...

A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosis These findings support CET polytherapy as an advantageous alternative compared to CuATSM monotherapy and highlight the potential of utilising small molecules targeting SOD1 as a polytherapy avenue for...

Congrats to Jeremy Lum, Justin Yerbury and Team for their new paper, "A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosis', that also involved the CMR's A/P Peter Crouch
#ALS
www.thelancet.com/journals/ebi...

Parkinson-like wild-type superoxide dismutase 1 pathology induces nigral dopamine neuron degeneration in a novel murine model - Acta Neuropathologica Atypical wild-type superoxide dismutase 1 (SOD1) protein misfolding and deposition occurs specifically within the degenerating substantia nigra pars compacta (SNc) in Parkinson disease. Mechanisms dri...

Congrats to Amr Abdeen, the CMR's A/P Peter Crouch, Kay Double, & Team, for their new paper, "Parkinson-like wild-type superoxide dismutase 1 pathology induces nigral dopamine neuron degeneration in a novel murine model"
#parkinson's
link.springer.com/article/10.1...

Congrats to Alastair Saunders on a great PhD oration on Metastatic Cancer and Muscle: Exploring the role of TGF-beta signaling in metastatic colonisation. The CMR and supervisors, Profs Paul Gregorevic & Robin Anderson, are very proud. Good luck with the thesis! #Myoblue #cancer #metastasis #muscle

The CMR's Craig Goodman @craigagoodman1.bsky.social
presenting on the ubiquitinomics of muscle hypertrophy in today's morning session on Muscle Growth and Regeneration at the Advances in Skeletal Muscle Biology (ASMB) Conference at UFMyology

A great opening session of speakers on the topic of cancer cachexia at the Advances in Skeletal Muscle Biology (ASMB) conference at UFMyology, which included the CMR's Prof Paul Gregorevic

To celebrate International Women’s Day, we would like to recognise the dedication and hard work of the amazing women (staff and students) of the CMR.
#internationalwomensday #IWD2025 #Myoblue