Ben-Sahra Lab

a pointilllist mito

Good Sunday, all. Don't miss this week's selection of papers in #cancermetabolism and #mitochondrialbiology as there are some true gems: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"The everyday human gesture is always a heartbeat away from the miraculous."-Nick Cave

A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis A fin-like structural loop in GPX4 is critical for anchoring the enzyme to cellular membranes, thereby preventing ferroptosis. A patient-associated R152H mutation destabilizes this loop, leading to fe...

A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis: Cell www.cell.com/cell/fulltex...

🚨The Yap Lab at Northwestern Univ is looking to fill 2 postdoc positions in 2026 to study aspects of Staphylococcus aureus antibiotic resistance and RNA synthesis-degradation. Please contact Frances Yap at frances.yap@northwestern.edu for details. sites.northwestern.edu/yaplab/. Pls repost #Microsky

Leveraging biochemical covariance to better understand biology In a recent Nature article, Xiao et al. report development of a metabolite-protein covariation architecture (MPCA) database from a diversity outbred mouse cohort that facilitates the deciphering of metabolite-protein relationships in liver and brown adipose tissue (BAT). Using these correlations, the authors describe a role for LRRC58 in controlling cysteine-taurine metabolism.

Leveraging biochemical covariance to better understand biology

Congrats to you and the team, my friend!

Human plasma‐like medium enhances structural and metabolic maturation of human pluripotent stem cell‐derived cardiomyocytes Human plasma-like medium (HPLM), a synthetic physiologic medium containing over 60 metabolites and small ions at concentrations reflective of adult human plasma, enhances the structural and metabolic....

happy to have collaborated on this v cool study led by Andy & Aaron from the Sean Palecek and Melissa Skala labs! culturing hPSC-CMs in HPLM effectively enhances their maturation vs traditional media ➡️ potential modeling implications for cardiac biology/CVD!

tinyurl.com/3yutyd8c

An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...

Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism

This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.

Please check it out!

www.nature.com/articles/s41...

Good Sunday!. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei

Congratulations, Alexis and team! Exciting findings!

Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...

Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉

Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team!

#NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social

🔗 www.nature.com/articles/s42...
🧵1/17

Good Sunday, all. The weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology is out, a concentrate of groundbreaking discoveries:

biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading

"There are years that ask questions and years that answer."-Zora Neale Hurston

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT | Science www.science.org/doi/10.1126/...

Great work from @rjdlab.bsky.social !!

2. A new paper in @cp-molcell.bsky.social from @bensahralab.bsky.social (ACS Discovery Boost grantee) and Dr. Marc Mendillo (ACS Research Scholar grantee) @luriecancer.bsky.social revealing a molecular link between succinate dehydrogenase and purine synthesis.

Read the paper here: lnkd.in/eibyMezn

Super excited to share that my second project in the @rjdlab.bsky.social is now published in Science! Many thanks to all co-authors, especially @ptnguyen.bsky.social for his expertise in structural biology and enzymology! And big thanks to Ralph for his incredible mentorship and support!

Congrats on this great discovery!🤩

A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis Folate metabolism is intricately linked to purine de novo synthesis through the incorporation of folate-derived one-carbon units into the purine scaffold. By investigating chemical and genetic depende...

New in @science.org 🧬

What if an enzyme you thought you knew turned out to control metabolism in a completely new way?

We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.

www.science.org/doi/10.1126/...

Really cool work! Congrats, Zheng, Ralph and whole team! 🎉👏

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...

1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase

www.science.org/doi/10.1126/...

Secretome translation shaped by lysosomes and lunapark-marked ER junctions - Nature Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lun...

www.nature.com/articles/s41...
Secretome translation shaped by lysosomes and lunapark-marked ER junctions

Congrats, Jess and team!!

Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1

www.nature.com/articles/s41...

Lymph node environment drives FSP1 targetability in metastasizing melanoma - Nature Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.

Excited to share my postdoctoral work, out today in Nature! www.nature.com/articles/s41...

We discovered that melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits melanoma progression.

Thinking like a Scientist: The Limits of Genome Editing and Omics Second part of Thinking like a Scientist, reflecting on how genome editing and multi-omics, while powerful, can introduce conceptual flaws that distort our understanding of gene function and biologica...

Following a recent article about the different layers of conceptualisation in a science project, this is about a pet peeve of mine. I would love to hear your views.

network.febs.org/posts/thinki...

Good Sunday, mitolovers. Here is a wonderful selection of papers in #cancermetabolism and #mitochondrialbiology:

biomed.news/bims-camemi/...

@biomednews.bsky.social #keepreading

"Coming back to where you started is not the same as never leaving."-Terry Pratchett

Thank you so much, Christian! 😊

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps://

www.sciencedirect.com/science/article/abs/pii/S1097276525008196

Congratulations @bensahralab.bsky.social !!

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!

shorturl.at/B5XYD

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...

Online Now: Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle Online now: